scholarly journals Safety of Pegfilgrastim (Neulasta) in Patients with Sickle Cell Trait/Anemia

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Pashtoon Murtaza Kasi ◽  
Mrinal M. Patnaik ◽  
Prema P. Peethambaram
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Trait ◽  
First Case ◽  
Sickle Cell Crisis ◽  
Sickle Cell Crises ◽  
Prescribing Information ◽  
Stimulating Factor ◽  
Caucasian Female ◽  
Actual Incidence ◽  
Pegylated Form

Pegfilgrastim (Neulasta) is a recombinant filgrastim (human granulocyte colony-stimulating factor (G-CSF)) attached to a polyethylene glycol (PEG) molecule and is given as part of chemotherapy regimens that are associated with significant myelosuppression and risk for febrile neutropenia. Prescribing information available on manufacturer’s website for the drug warns us about possible severe sickle cell crises related to the medication but does not report the actual incidence or the use in patients with sickle cell trait. Caution is advised when using it in patients with sickle cell disease. Here we present a case of a Caucasian female with known sickle cell trait (SCT) with no prior complications who developed a presumed sickle cell crisis after getting Neulasta, as a part of the chemotherapy regimen used to treat her breast cancer. Based on our literature review, this appears to be the first case report of a patient with SCT developing a sickle cell crisis with the pegylated form of recombinant filgrastim. Given the dearth of literature regarding the use of G-CSF and its related pegylated forms in patients with sickle cell anemia and sickle cell trait, a discussion of potential mechanisms and review of current literature and guidelines is also presented.

Sickle cell crisis as evaluated from measurements of hydroxybutyrate dehydrogenase and myoglobin in plasma.

1981 ◽  
Vol 27 (2) ◽  
pp. 314-316 ◽  
Author(s):  
E F Roth ◽  
P A Bardfeld ◽  
S J Goldsmith ◽  
E Radel ◽  
J C Williams
Keyword(s):  
Steady State ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
High Specificity ◽  
Mean Value ◽  
Cell Disease ◽  
Sickle Cell Crisis ◽  
The Mean ◽  
Low Sensitivity ◽  
Sickle Cell Crises

Abstract Data on plasma hydroxybutyrate dehydrogenase activity (I) and myoglobin concentration were used to evaluate painful sickle cell crises. I was increased during non-crisis steady state in patients with sickle cell disease as compared to normal values (232, SD 79.7 vs 85, SD 33 Sigma units/mL). During crisis, the mean value for I increased further to 379 (SD 139) Sigma units/mL. For 12 patients evaluated both during steady state and crisis, there was a mean increase in plasma I of 131% (SD 76%). Repeated determinations of I in sickle cell disease patients during several months while they were in steady state showed that baseline I varied by no more than 20% from the mean. Plasma myoglobin in patients with sickle cell disease was not above normal, but during crisis 21 of 39 patients tested had increased plasma myoglobin concentrations. Our data suggest that I may be a useful indicator of sickle cell crisis when the patient's own baseline value is available for comparison. Plasma myoglobin measurements give evidence of muscle damage during crisis with high specificity but low sensitivity.

Fatal sickle cell crisis after granulocyte colony-stimulating factor administration

Blood ◽  
2001 ◽  
Vol 97 (10) ◽  
pp. 3313-3314 ◽  
Author(s):  
Brian K. Adler ◽  
Donna E. Salzman ◽  
Matthew H. Carabasi ◽  
William P. Vaughan ◽  
Vishnu V. B. Reddy ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Sickle Cell Crisis ◽  
Stimulating Factor

scholarly journals Red cells in sickle cell crisis: observations on the pathophysiology of crisis

Blood ◽  
1977 ◽  
Vol 49 (6) ◽  
pp. 967-979 ◽  
Author(s):  
EE Rieber ◽  
G Veliz ◽  
S Pollack
Keyword(s):  
Sickle Cell ◽  
Red Cells ◽  
Red Cell ◽  
Molecular Abnormality ◽  
Sickle Cell Crisis ◽  
Sickle Cell Crises

Abstract The pathophysiology of the occurrence and resolution of sickle cell crisis is unknown. The molecular abnormality is constant, while crisis is episodic. In the present study, red cell filterability and sickling with deoxygenation have been measured during sickle cell crises. Recovery from sickle crisis is associated with an increased filterability of the circulating red cell and a decreased susceptibility of the red cell to sickle with deoxygenation (p less than 0.05). The possibility that these changes are responsible for the resolution of crisis is suggested.

Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor

2019 ◽  
Vol 25 (8) ◽  
pp. 2056-2058 ◽  
Author(s):  
Divya Doval ◽  
Dharma Choudhary ◽  
Sanjeev K Sharma ◽  
Vipin Khandelwal
Keyword(s):  
Stem Cell ◽  
Sickle Cell ◽  
Anaphylactoid Reaction ◽  
Sickle Cell Trait ◽  
Complete Recovery ◽  
Fluid Bolus ◽  
Cell Donor ◽  
Anaphylactoid Reactions ◽  
Stimulating Factor ◽  
Stem Cell Collection

Introduction Granulocyte–colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis. Case report We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis. Management and outcome He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest. Conclusion There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported.

scholarly journals SCREENING OF FUNGI FOR PRODUCTION AND PURIFICATION OF OMEGA-3 FATTYACID

2021 ◽  
Vol 10 (4) ◽  
pp. 3388-3393
Author(s):  
Monali Rajendra kumar Sahu
Keyword(s):  
Viral Hepatitis ◽  
Sickle Cell ◽  
Intrahepatic Cholestasis ◽  
Omega 3 ◽  
Sickle Cell Crisis ◽  
Sickle Cell Crises

Sickle cell hemoglobinopathy patients are vexed with sickle cell crises crises all through their life. Occurrence of jaundice in these patients is quite common and when present gets ascribed to the sickle cell crisis, sickle cell hepatopathy, intrahepatic cholestasis or cholelithisis. Further, incidence of viral hepatitis is extremely common in these patients. Clinically it is difficult to distinguish this aetiology. We have attempted to identify the criteria to help differentiate amongst sicklers which patients should be investigated for viral hepatitis. Also, sicklers with hepatitis have been studied against non sicklers with hepatitis and also complications of hepatitis in these two groups.

scholarly journals Acute Sickle Hepatic Crisis after Liver Transplantation in a Patient with Hb SC Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
J. H. Gillis ◽  
S. K. Satapathy ◽  
L. Parsa ◽  
P. B. Sylvestre ◽  
N. Dbouk
Keyword(s):  
Liver Transplantation ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Complete Recovery ◽  
Beta Thalassemia ◽  
Low Grade ◽  
Cell Disease ◽  
First Case ◽  
Number Of Patients

Acute sickle hepatic crisis (ASHC) has been observed in approximately 10% of patients with sickle cell disease. It occurs predominantly in patients with homozygous (Hb SS) sickle cell anemia and to a lesser degree in patients with Hb SC disease, sickle cell trait, and Hb S beta thalassemia. Patients commonly present with jaundice, right upper quadrant pain, nausea, low-grade fever, tender hepatomegaly, and mild to moderate elevations in serum AST, ALT, and bilirubin. We describe the case of a patient with a history of hemoglobin SC disease and cirrhosis caused by hepatitis C presenting approximately 1 year after liver transplantation with an ASHC. The diagnosis was confirmed by liver biopsy. Our patient was treated with RBC exchange transfusions, IV hydration, and analgesia and made a complete recovery. Only a limited number of patients with sickle cell disease have received liver transplants, and, to our knowledge, this is the first case of ASHC after transplantation in a patient with Hb SC disease.

scholarly journals Failure of desmopressin to lower serum sodium or prevent crisis in patients with sickle cell anemia

Blood ◽  
1981 ◽  
Vol 58 (5) ◽  
pp. 892-896
Author(s):  
S Charache ◽  
WG Walker
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Serum Sodium ◽  
Fluid Intake ◽  
Sodium Restriction ◽  
Lower Serum ◽  
Chronic Hyponatremia ◽  
Sickle Cell Crisis ◽  
Rigorous Treatment ◽  
Sickle Cell Crises

An analogue of arginine vasopressin (desmopressin, DDAVP) was evaluated for production chronic hyponatremia and prevention of sickle cell crisis. With sodium restriction (100 meq Na + / day) and water loading ( greater than 3 liters/day), persistent hyponatremia could not be achieved, nor could crises be prevented or aborted. Patients would not comply with a regimen of lower salt and higher fluid intake. More rigorous treatment might be practical during acute sickle cell crises, and a regimen similar to that used here might be more effective in children, whose renal concentrating mechanisms are still intact.

Red cells in sickle cell crisis: observations on the pathophysiology of crisis

Blood ◽  
1977 ◽  
Vol 49 (6) ◽  
pp. 967-979
Author(s):  
EE Rieber ◽  
G Veliz ◽  
S Pollack
Keyword(s):  
Sickle Cell ◽  
Red Cells ◽  
Red Cell ◽  
Molecular Abnormality ◽  
Sickle Cell Crisis ◽  
Sickle Cell Crises

The pathophysiology of the occurrence and resolution of sickle cell crisis is unknown. The molecular abnormality is constant, while crisis is episodic. In the present study, red cell filterability and sickling with deoxygenation have been measured during sickle cell crises. Recovery from sickle crisis is associated with an increased filterability of the circulating red cell and a decreased susceptibility of the red cell to sickle with deoxygenation (p less than 0.05). The possibility that these changes are responsible for the resolution of crisis is suggested.

Hemobilia: Secondary to Sickle Cell Crisis - The First Case Report

2010 ◽  
Vol 105 ◽  
pp. S218
Author(s):  
Vijaypal Arya ◽  
Mohammed Mazumder ◽  
Nithan Narendra ◽  
Sweety Jayswal
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
First Case ◽  
Sickle Cell Crisis
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