scholarly journals Giant Cell Tumor of Lower End of Tibia

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Monish Bami ◽  
Ashok R. Nayak ◽  
Shreepad Kulkarni ◽  
Avinash Kulkarni ◽  
Rupali Gupta
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Ankle Joint ◽  
Mononuclear Cells ◽  
Full Range ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Primary Tumors ◽  
Vesicular Nucleus ◽  
Left Ankle

Introduction. Giant cell tumor of bones is an unusual neoplasm that accounts for 4% of all primary tumors of bone, and it represents about 10% of malignant primary bone tumors with its different grades from borderline to high grade malignancy.Case Report. A 35-year-old patient presented with complains of pain and swelling in left ankle since 1 year following a twisting injury to his left ankle. On examination, swelling was present over the distal and anterior part of leg and movements of ankle joint were normal. All routine blood investigations were normal. X-ray and CT ankle showed morphology of subarticular well-defined expansile lytic lesion in lower end of left tibia suggestive of giant cell tumor. Histopathology of the tissue shows multinucleated giant cells with uniform vesicular nucleus and mononuclear cells which are spindle shaped with uniform vesicular nucleus suggestive of GCT. The patient was treated by excision, curettage, and bone cement to fill the defect.Conclusion. The patient at 12-month followup is doing well and walking without any pain comfortably and with full range of motion at ankle joint with articular congruity maintained and no signs of recurrences.

scholarly journals Giant Cell Tumor of the Patella: An Uncommon Site

2018 ◽  
Vol 8 (1) ◽  
pp. 30-32
Author(s):  
Karun Devkota ◽  
Manoj Bhattarai ◽  
Kapil Adhikari
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Lytic Lesion ◽  
Contrast Study ◽  
Post Contrast ◽  
Primary Tumors ◽  
Radiological Features ◽  
Soft Tissue Involvement ◽  
Anterior Knee

Primary tumors of the patella are rare of which Giant cell tumor is the most frequent. Patient usually presents with pain in anterior knee and swelling. Radiologically, Giant cell tumor usually presents as a well defined lytic lesion with no sclerotic margin, no periosteal reaction and no soft tissue involvement unless complicated by fracture and shows enhancement on post-contrast study. Herein, we report the case of a 31-year female with giant cell tumor of the patella (GCT) with its clinical and radiological features.

Giant Cell Poor Extra-Articular Diffuse-Type Tenosynovial Giant Cell Tumor With Extensive Desmin Expression: A Potential Diagnostic Pitfall With Cytogenetic Confirmation

2018 ◽  
Vol 27 (1) ◽  
pp. 59-61
Author(s):  
Liurka Lopez ◽  
Karen Schoedel ◽  
Ivy John
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
Diffuse Type ◽  
Tenosynovial Giant Cell Tumor ◽  
Diagnostic Pitfall

Diffuse-type tenosynovial giant cell tumor can rarely present as an entirely extra-articular mass, which can be misdiagnosed as a sarcoma especially when giant cells are absent, dominated by large dendritic mononuclear cells, and desmin expression is extensive.

Calcitonin receptors on neoplastic mononuclear cells cultured from a human giant-cell tumor of the sacrum

1994 ◽  
Vol 120 (5) ◽  
pp. 272-278 ◽  
Author(s):  
Akio Maeda ◽  
Hisao Matsui ◽  
Masahiko Kanamori ◽  
Kazuo Yudoh ◽  
Haruo Tsuji
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Cell Tumor ◽  
Calcitonin Receptors ◽  
Cells Cultured

Giant Cell Tumor of Tendon Sheath: Immunohistochemical Study of 20 Cases

1997 ◽  
Vol 83 (5) ◽  
pp. 841-846 ◽  
Author(s):  
Antonio Cavaliere ◽  
Angelo Sidoni ◽  
Emilio Bucciarelli
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Neuron Specific Enolase ◽  
Synovial Cell ◽  
Tendon Sheath ◽  
Giant Cells ◽  
Cell Tumor ◽  
Electron Microscopic ◽  
Filament Bundles

Aims and background Giant cell tumor of tendon sheath (GCTTS) is a common tumor occurring on the tendon sheaths of the fingers. The nature of this lesion is still controversial: some researchers consider it a reactive process arising from chronic inflammation while others regard it as a tumor of presumed synovial cell or monocytic macrophage system origin. In an effort to clarify the histogenesis we decided to further investigate the immunophenotypic profile of this tumor. Study design We studied 20 GCTTS of the fingers using a panel of 18 antibodies, 13 monoclonal and 5 polyclonal. Results The immunohistochemical investigation revealed that the mononuclear cells of this lesion can be divided into two groups. The cells of the first and more numerous group were positive for vimentin, PG-M1 and KP1 but also for muscle actin (HHF35 monoclonal antibody) and neuron-specific enolase. A second population of mononuclear cells, usually arranged around the giant cells, were positive for PG-M1, KP1, LCA and occasionally for alpha-1-antitrypsin and alpha-1-antichymotrypsin. Multinucleated giant cells were also positive for KP1, PG-M1 and LCA monoclonal antibodies. A variable but usually weak positivity for al-pha-1-antitrypsin, alpha-1-antichymotrypsin and lysozyme was also observed. Conclusions Our results suggest a synovial cell origin for GCTTS and do not support the hypothesis that it could be a neoplasm with a true histiocytic origin. The positivity of some cells for the HHF35 antibody, together with electron microscopic evidence of filament bundles with focal dense bodies, suggests that at least part of the mononuclear cells may have a myofibroblastic differentiation.

Histomorphometric Analysis of Pre- and Post-Denosumab–Treated Giant Cell Tumor of Bone

2020 ◽  
Vol 28 (8) ◽  
pp. 859-867
Author(s):  
Nasir Ud Din ◽  
Masood Umer ◽  
Yong-Koo Park
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cells ◽  
Mononuclear Cells ◽  
Giant Cells ◽  
Cell Tumor ◽  
P Value ◽  
Osteoblastic Activity ◽  
Woven Bone ◽  
Hematoxylin And Eosin

Context. Denosumab is a monoclonal antibody against RANK ligand. Its administration in giant cell tumor of bone (GCTB) cases results in elimination of giant cells and new bone formation. Neoplastic stromal cells of GCTB harbor mutation of histone 3.3 and have pre-osteoblastic properties and thus express SATB2. Objectives. To (1) analyze histological changes in post-denosumab–treated GCTB, (2) analyze expression of H3.3G34W and SATB2 in pre- and post-denosumab–treated samples, and (3) to discuss why changes occur in the expression of not only H3.3G34W but also SATB2. Materials and Methods. Hematoxylin and eosin slides of 19 cases of denosumab-treated GCTB were reviewed. Immunohistochemical stains H3.3G34W and SATB2 were performed. The number of positive mononuclear cells were counted and graded. Results. Complete absence of osteoclast-like giant cells (OCLGCs) was noted in most cases along with a fibro-osseous component merging with peripheral shell of reactive bone. Irregular trabeculae of woven bone and osteoid with focal osteoblastic rimming was seen. Spindle cells were arranged predominantly in fascicular pattern. Morphometric analysis of H3.3G34W showed a mean of 68.8% positive stromal cells in pretreatment and a mean of 26.9% positive stromal cells in posttreated specimens with a statistically significant P value (.001). Mean percentage of SATB2-positive stromal cells in the pre- and posttreatment specimens was 36.46% and 20.8%, respectively. Conclusions. Our study validates that denosumab treatment results in marked reduction of OCLGCs with increased osteoblastic activity. Decreased expression of H3.3G34W in posttreatment may be a result of decreased antigenicity of neoplastic mononuclear cells. No significant change in SATB2 expression was noted.

scholarly journals A Case Report of Giant Cell Tumor of Proximal Fibula in Children

2020 ◽  
Vol 4 (1) ◽  
pp. 64-67
Author(s):  
Sushil Adhikari ◽  
Arun Sigdel ◽  
Rajesh Kumar Sah ◽  
Luna Devkota
Keyword(s):  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Long Bone ◽  
Lytic Lesion ◽  
Radiographic Appearance ◽  
X Ray ◽  
Proximal Fibula ◽  
Aggressive Tumor

Giant cell tumour (GCT) is histopathologically benign tumor of long bone particularly in distal femur and the proximal tibia. It commonly occurs in adults of age 20-40 years but rare in children. GCT is considered to be locally aggressive tumor and tendency of recurrence is higher even after surgery. The clinical features are nonspecific, the principle symptoms are pain, swelling and limiting adjacent joint movements. Diagnosis is based on the radiographic appearance and histopathological findings .In our case X-ray showed ill defined lytic lesion on proximal fibula with cortical thinning and MRI finding revealed expansile lyticlesion in meta-epiphysis of right fibula 16×16×28mm adjacent to growth plate with fluid level. The sclerotic rim appears hypo intense on T1 & hyper intense on T2. Core needle biopsy showed giant cell tumor on proximal fibula. Considering the risk of recurrence wide local excision was done. Management of GCT of proximal fibula in young patient is critical for preventing recurrence and enhancing functional outcomes by saving adjacent anatomical structure. No evidence of local recurrence and metastasis was found in 24 months of follow up.

Giant Cell Tumor of Soft Tissue with Pulmonary Metastases: Pathologic and Cytogenetic Study

2005 ◽  
Vol 8 (6) ◽  
pp. 718-724 ◽  
Author(s):  
Hua Guo ◽  
Roberto A. Garcia ◽  
Mary Ann Perle ◽  
John Amodio ◽  
M. Alba Greco
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
Chromosomal Abnormalities ◽  
Cytogenetic Study ◽  
Giant Cells ◽  
Cell Tumor ◽  
General Acceptance ◽  
Telomeric Association

Giant cell tumor of soft tissue (GCTST) has gained general acceptance as an uncommon but distinct primary soft tissue tumor since it was first described in 1972. GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like giant cells admixed with oval to polygonal mononuclear cells. It usually follows a benign clinical course, although the malignant variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features. It is still not clear whether the two variants belong to the spectrum of the same tumor. No cytogenetic chromosomal abnormalities have been reported in the literature of GCTST. Interestingly, the osseous counterpart of giant cell tumor, which shares similar histologic features, quite often displays a telomeric association at the cytogenetic level, a finding that has never been reported in GCTST. We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes.

scholarly journals First Experience of Ankle Joint Arthroplasty in a Giant Cell Tumor of the Tibial Epiphysiometaphys: Case Report and Literature Review

2017 ◽  
pp. 56-61
Author(s):  
A. I. Snetkov ◽  
G. N. Berchenko ◽  
A. R. Frantov ◽  
S. Yu. Batrakov ◽  
R. S. Kotlyarov ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Ankle Joint ◽  
Surgical Intervention ◽  
Joint Arthroplasty ◽  
Cell Tumor ◽  
Custom Made ◽  
The Right

Case report for the 18 years old female patient with a giant cell tumor of the distal articular end of the right tibia is presented. The surgical intervention included segmental resection of the articular end of the right tibia and substitution of the defect with the custom-made ankle endoprosthesis. The follow up period made up 4 years. The range of motion in the right ankle joint was satisfactory, no relapse occurred and the implant components were stable. 

scholarly journals Recurrent diffuse-type tenosynovial giant cell tumor of the left ankle: a case report

2019 ◽  
Vol 3 ◽  
pp. 17-17
Author(s):  
Chun-Chieh Wu ◽  
Ying-Hsiang Chou ◽  
Wei-Jia Yang ◽  
Jeng-Dong Hsu ◽  
Hsien-Chun Tseng ◽  
...  
Keyword(s):  
Case Report ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Cell Tumor ◽  
Diffuse Type ◽  
Tenosynovial Giant Cell Tumor ◽  
Left Ankle

scholarly journals Primary mediastinal giant cell tumor

Rare Tumors ◽  
2009 ◽  
Vol 1 (2) ◽  
pp. 141-142
Author(s):  
Judd Goldberg ◽  
Shameen Azizad ◽  
Jela Bandovic ◽  
Arfa Khan
Keyword(s):  
Soft Tissue ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Mononuclear Cells ◽  
English Literature ◽  
Giant Cells ◽  
Posterior Mediastinum ◽  
Cell Tumor ◽  
Distinct Entity ◽  
Posterior Mediastinal

Giant cell tumor of soft tissue is a rare tumor first described by Salm and Sissons in 1972 as being a distinct entity. 1 Histologically, it is composed of multinucleated giant cells dispersed among mononuclear cells, and is indistinguishable from its bone equivalent. 2 The majority of these tumors have been reported to occur in the lower extremity. 2 , 3 We describe a case of giant cell tumor of soft tissue within the posterior mediastinum. The only other report of a primary mediastinal giant cell tumor of soft tissue in the English literature was published by Fu et al. in 2002, in which they described two patients with posterior mediastinal masses. 4

Sign in / Sign up

Export Citation Format

Share Document