scholarly journals Preliminary Experience with Small Animal SPECT Imaging on Clinical Gamma Cameras

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
P. Aguiar ◽  
J. Silva-Rodríguez ◽  
M. Herranz ◽  
A. Ruibal
Keyword(s):  
Animal Studies ◽  
Small Animal ◽  
Spect Imaging ◽  
Portable Device ◽  
Preclinical Research ◽  
Preclinical Imaging ◽  
Gamma Cameras ◽  
Widespread Availability ◽  
Phantom Experiments

The traditional lack of techniques suitable forin vivoimaging has induced a great interest in molecular imaging for preclinical research. Nevertheless, its use spreads slowly due to the difficulties in justifying the high cost of the current dedicated preclinical scanners. An alternative for lowering the costs is to repurpose old clinical gamma cameras to be used for preclinical imaging. In this paper we assess the performance of a portable device, that is, working coupled to a single-head clinical gamma camera, and we present our preliminary experience in several small animal applications. Our findings, based on phantom experiments and animal studies, provided an image quality, in terms of contrast-noise trade-off, comparable to dedicated preclinical pinhole-based scanners. We feel that our portable device offers an opportunity for recycling the widespread availability of clinical gamma cameras in nuclear medicine departments to be used in small animal SPECT imaging and we hope that it can contribute to spreading the use of preclinical imaging within institutions on tight budgets.

A portable device for small animal SPECT imaging in clinical gamma-cameras

2014 ◽  
Vol 9 (07) ◽  
pp. P07004-P07004 ◽  
Author(s):  
P Aguiar ◽  
J Silva-Rodríguez ◽  
D M González-Castaño ◽  
F Pino ◽  
M Sánchez ◽  
...  
Keyword(s):  
Small Animal ◽  
Spect Imaging ◽  
Portable Device ◽  
Gamma Cameras

scholarly journals Development of a High-resolution SSR-SPECT System for Preclinical Imaging and Neuroimaging

2021 ◽  
Author(s):  
Annunziata D'Elia ◽  
Andrea Soluri ◽  
Filippo Galli ◽  
Sara Schiavi ◽  
Giselda De Silva ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Emission Computed Tomography ◽  
Preclinical Research ◽  
Preclinical Imaging ◽  
Spect System

Abstract The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. In particular, techniques like single photon emission computed tomography (SPECT) show high potential, which is usually limited by spatial resolution. This represents an important parameter influencing scanner design, given the small size of the anatomical structures to be investigated. The purpose of the present work was to assess the performance of a scintigraphic system with improved spatial resolution based on our previous detector by applying the Super Spatial Resolution (SSR). Our dual-head SPECT system is composed of gamma cameras based on the Hamamatsu H13700 position-sensitive photomultiplier tube (PSPMT). In each detector head, the PSPMT is coupled to a 28×28 array of CRY018 scintillation crystals. The pure Tungsten parallel square hole collimator ensures the position sensitivity, and a dedicated resistive chain readout so as an ADC board have been proprietary designed. To finalize the mechanical development of the SSR-SPECT system several tests were carried out. Based on the results obtained in the test phase, a partial review of the mechanical design was performed. Then a dedicated machine handling software was developed, and in particular, a kinematic software debugging and testing was assessed. Finally, several experiments were carried out by using Derenzo phantoms and capillaries filled with radioactive sources. Finally, the performance of our system was evaluated performing small animal imaging studies. The SPECT spatial resolution was experimentally determined to be about 1.6 mm. We reach a resolution of 1.18 mm by applying the SSR based on two images. The results of this study demonstrated the good capability of the system as a suitable tool for preclinical imaging especially in fields like neuroscience for the study of small brain structures.

scholarly journals Implementation of absolute quantification in small‐animal SPECT imaging: Phantom and animal studies

2017 ◽  
Vol 18 (4) ◽  
pp. 215-223 ◽  
Author(s):  
Shabnam Khorasani Gerdekoohi ◽  
Naser Vosoughi ◽  
Kaveh Tanha ◽  
Majid Assadi ◽  
Pardis Ghafarian ◽  
...  
Keyword(s):  
Animal Studies ◽  
Small Animal ◽  
Absolute Quantification ◽  
Spect Imaging

Development of a novel radiation imaging detector system for in vivo gene imaging in small animal studies

1998 ◽  
Vol 45 (3) ◽  
pp. 1743-1749 ◽  
Author(s):  
A.G. Weisenberger ◽  
E.L. Bradley ◽  
S. Majewski ◽  
M.S. Saha
Keyword(s):  
Animal Studies ◽  
Small Animal ◽  
Detector System ◽  
Radiation Imaging ◽  
Imaging Detector

scholarly journals Magnetic Resonance Imaging for Translational Research in Oncology

2019 ◽  
Vol 8 (11) ◽  
pp. 1883 ◽  
Author(s):  
Maria Felicia Fiordelisi ◽  
Carlo Cavaliere ◽  
Luigi Auletta ◽  
Luca Basso ◽  
Marco Salvatore
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Small Animal ◽  
Laboratory Animals ◽  
Resonance Imaging ◽  
Preclinical Research ◽  
Ongoing Research ◽  
Wide Range

The translation of results from the preclinical to the clinical setting is often anything other than straightforward. Indeed, ideas and even very intriguing results obtained at all levels of preclinical research, i.e., in vitro, on animal models, or even in clinical trials, often require much effort to validate, and sometimes, even useful data are lost or are demonstrated to be inapplicable in the clinic. In vivo, small-animal, preclinical imaging uses almost the same technologies in terms of hardware and software settings as for human patients, and hence, might result in a more rapid translation. In this perspective, magnetic resonance imaging might be the most translatable technique, since only in rare cases does it require the use of contrast agents, and when not, sequences developed in the lab can be readily applied to patients, thanks to their non-invasiveness. The wide range of sequences can give much useful information on the anatomy and pathophysiology of oncologic lesions in different body districts. This review aims to underline the versatility of this imaging technique and its various approaches, reporting the latest preclinical studies on thyroid, breast, and prostate cancers, both on small laboratory animals and on human patients, according to our previous and ongoing research lines.

scholarly journals Attenuation Correction for Small Animal PET Images: A Comparison of Two Methods

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Daniela D'Ambrosio ◽  
Federico Zagni ◽  
Antonello E. Spinelli ◽  
Mario Marengo
Keyword(s):  
Attenuation Correction ◽  
Animal Studies ◽  
Spinal Column ◽  
Small Animal ◽  
Small Animal Pet ◽  
X Rays ◽  
Beam Hardening ◽  
Photon Attenuation ◽  
Bone Scans

In order to extract quantitative parameters from PET images, several physical effects such as photon attenuation, scatter, and partial volume must be taken into account. The main objectives of this work were the evaluation of photon attenuation in small animals and the implementation of two attenuation correction methods based on X-rays CT and segmentation of emission images. The accuracy of the first method with respect to the beam hardening effect was investigated by using Monte Carlo simulations. Mouse- and rat-sized phantoms were acquired in order to evaluate attenuation correction in terms of counts increment and recovery of uniform activity concentration. Both methods were applied to mice and rat images acquired with several radiotracers such asF18-FDG,11C-acetate,68Ga-chloride, andF18-NaF. The accuracy of the proposed methods was evaluated in heart and tumour tissues usingF18-FDG images and in liver, kidney, and spinal column tissues usingC11-acetate,Ga68-chloride, andF18-NaF images, respectively.In vivoresults from animal studies show that, except for bone scans, differences between the proposed methods were about 10% in rats and 3% in mice. In conclusion, both methods provide equivalent results; however, the segmentation-based approach has several advantages being less time consuming and simple to implement.

scholarly journals A Meta-Analysis of Resveratrol Protects against Myocardial Ischemia/Reperfusion Injury: Evidence from Small Animal Studies and Insight into Molecular Mechanisms

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Zhi-Jie Mao ◽  
Hui Lin ◽  
Jian-Wen Hou ◽  
Qian Zhou ◽  
Qian Wang ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Infarct Size ◽  
Animal Studies ◽  
Ex Vivo ◽  
Ischemia Reperfusion ◽  
Meta Analysis ◽  
Small Animal ◽  
Route Of Administration ◽  
Myocardial Ischemia Reperfusion

Aims. Myocardial ischemia/reperfusion (I/R) injury is a leading cause of cardiomyocyte loss and subsequent ventricular dysfunction after restoring the coronary blood flow and contributes to considerable increase in morbidity and mortality. Resveratrol has been declared to confer cardioprotection against in vivo and ex vivo myocardial I/R injury. Here, we have sought to investigate the effects of preconditioning with resveratrol on myocardial I/R damage across the small animal studies. Methods and Results. The MEDLINE, Google Scholar, PubMed, and Cochrane databases were searched for preclinical studies investigating resveratrol vs. vehicle published from the inception to July 2018. Eventually, 10 in vivo and 7 ex vivo studies with 261 animals (130 for resveratrol; 131 for vehicle) were included for meta-analysis. Pooled estimates for primary outcomes demonstrated that pretreatment with resveratrol significantly reduced the infarct size after myocardial I/R injury irrespective of in vivo (weighted mean difference (WMD): -13.42, 95% CI: -16.63 to -10.21, P≤0.001) or ex vivo (WMD: -15.05, 95% CI: -18.23 to -11.86, P≤0.001) studies. Consistently, stratified analysis according to the reperfusion duration, route of administration, or timing regimen of pretreatment all showed the infarct-sparing benefit of resveratrol. Metaregression did not indicate any difference in infarct size based on species, sample size, state, route of administration, reperfusion duration, and timing regimen of pretreatment. Meanwhile, sensitivity analysis also identified the cardioprotection of resveratrol with robust results in spite of significant heterogeneity. Conclusions. Preconditioning with resveratrol appears to prevent the heart from I/R injury in comparison with vehicle, as evidenced by limited infarct size in a preclinical setting. Studies with large animals or randomized controlled trials will add more evidence and provide the rationale for clinical use.

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