scholarly journals Production of the Growth Factors GM-CSF, G-CSF, and VEGF by Human Peripheral Blood Cells Induced with Metal Complexes of Human Serumγ-Globulin Formed with Copper or Zinc Ions

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Sergey B. Cheknev ◽  
Maria A. Apresova ◽  
Nadezhda A. Moryakova ◽  
Irina E. Efremova ◽  
Anna S. Mezdrokhina ◽  
...  

As it was established in our previous studies, the proteins of human serumγ-globulin fraction could interact with copper or zinc ions distributed in the periglobular space, form metal complexes, and become able to perform effector functions differing due to the conformational shifts from those mediated by them in native conformation of their Fc regions. In the present work we have evaluated ability of theγ-globulin metal complexes formed with copper or zinc ions in the conditions like to the physiological ones to induce production or to regulate induction in the culture of freshly isolated human peripheral blood cells (PBC) of granulocyte (G) and granulocyte-macrophage (GM) colony-stimulating factors (CSF) as well as of vascular endothelial growth factor (VEGF). Theγ-globulin metal complexes formed with both copper and zinc ions were found to similarly reduce production of GM-CSF, G-CSF, and VEGF induced in normal human PBC cultures by the controlγ-globulins or by copper and zinc ions used alone. In context of theory and practice of inflammation the properties of theγ-globulin metal complexes might impact the basic knowledge in search of novel approaches to anti-inflammatory drugs development.

2018 ◽  
Vol 189 (5) ◽  
pp. 529-540 ◽  
Author(s):  
Andreas Lamkowski ◽  
Matthias Kreitlow ◽  
Jörg Radunz ◽  
Martin Willenbockel ◽  
Frank Sabath ◽  
...  

Chemosphere ◽  
2019 ◽  
Vol 214 ◽  
pp. 623-632 ◽  
Author(s):  
Marko Gerić ◽  
Goran Gajski ◽  
Ana-Marija Domijan ◽  
Vera Garaj-Vrhovac ◽  
Metka Filipič ◽  
...  

2007 ◽  
Vol 40 (4) ◽  
pp. 476-478 ◽  
Author(s):  
Renata Aparecida Martinez Antunes Ribeiro-Vieira ◽  
Daniel Araki Ribeiro ◽  
Daisy Maria Favero Salvadori ◽  
Sílvio Alencar Marques

Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients with paracoccidioidomycosis by using the comet assay. The results suggested that paracoccidioidomycosis does not cause genotoxicity.


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