scholarly journals The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Carla Loreto ◽  
Giampiero La Rocca ◽  
Rita Anzalone ◽  
Rosario Caltabiano ◽  
Giuseppe Vespasiani ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Tunica Albuginea ◽  
Fibrous Tissue ◽  
Peyronie’S Disease ◽  
Ossification Center ◽  
Apoptotic Cells ◽  
Intrinsic Pathway ◽  
Caspase 9 ◽  
Peyronie's Disease ◽  
Metaplastic Bone

Peyronie’s disease (PD) is characterized with formation of fibrous plaques which result in penile deformity, pain, and erectile dysfunction. The aim of this study was to investigate the activation of the intrinsic apoptotic pathway in plaques from PD patients. Tunica albuginea from either PD or control patients was assessed for the expression of bax, bcl-2 and caspases 9 and 3 using immunohistochemistry and by measurement of apoptotic cells using TUNEL assay. Bax overexpression was observed in metaplastic bone tissue, in fibroblasts, and in myofibroblast of plaques from PD patients. Little or no bcl-2 immunostaining was detected in samples from either patients or controls. Caspase 3 immunostaining was very strong in fibrous tissue, in metaplasic bone osteocytes, and in primary ossification center osteoblasts. Moderate caspase 9 immunostaining was seen in fibrous cells plaques and in osteocytes and osteoblasts of primary ossification centers from PD patients. Control samples were negative for caspase 9 immunostaining. In PD patients the TUNEL immunoassay showed intense immunostaining of fibroblasts and myofibroblasts, the absence of apoptotic cells in metaplasic bone tissue and on the border between fibrous and metaplastic bone tissue. Apoptosis occurs in stabilized PD plaques and is partly induced by the intrinsic pathway.

Initial experience in the treatment of Peyronie’s disease using testicular vaginal tunica graft

2021 ◽  
pp. 205141582110166
Author(s):  
Rico Luis ◽  
Villasante Nicolás ◽  
Blas Leandro ◽  
Bonnano Nicolás ◽  
Ameri Carlos
Keyword(s):  
Sexual Function ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Sexual Life ◽  
Rank Test ◽  
Penile Curvature ◽  
Initial Experience ◽  
Level Of Evidence ◽  
Paired Samples ◽  
Peyronie's Disease

Background: Peyronie’s disease (PD) is a progressive disorder of the connective tissue of the tunica albuginea of the penis that produces an abnormal curvature, painful erections and different degrees of erectile dysfunction (ED). The aim of this study is to evaluate our initial experience in the surgical treatment of PD using an autologous graft of testicular vaginal tunica. Materials and methods: A retrospective study of 23 patients was carried out between 2015 and 2019. The successful surgical stretching rate was defined as a functional 20 degrees of curvature or less. Postoperative sexual function and complications rate were evaluated as secondary objectives. We used the abbreviated IIEF-5 questionnaire and evaluated the sexual function before and after the surgical procedure. Wilcoxon signed-rank test for paired samples (U test) was used, considering a value of p<0.05 to be statistically significant. Results: Only one patient presented a recurrence of the penile curvature, resulting in a 95.6% success rate of functional stretching. We observed a 1.6 and 0.9 difference between pre- and postoperative total score and satisfaction ( p = 0.002 and p = 0.003 respectively) Conclusion: In this series, the use of testicular vaginal tunic was found to be safe and effective with a significant change in the quality of sexual life, especially reflected in the overall satisfaction after the procedure and a low rate of complications. Level of evidence: Not applicable for this multicentre audit.

Surgical Treatment of Peyronie’s Disease: Systematic Review of Techniques Involving or Not Tunica Albuginea Incision

2020 ◽  
Vol 8 (2) ◽  
pp. 324-332 ◽  
Author(s):  
Alan R.G. Barbosa ◽  
Lucas S. Takemura ◽  
Jonathan D. Cha ◽  
Arie Carneiro ◽  
Gustavo C. Lemos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Surgical Treatment ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

A clinico-aetiological and ultrasonographic study of Peyronie's disease

Sexual Health ◽  
2006 ◽  
Vol 3 (2) ◽  
pp. 113 ◽  
Author(s):  
Bhushan Kumar ◽  
Tarun Narang ◽  
Somesh Gupta ◽  
Madhu Gulati
Keyword(s):  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Tunica Albuginea ◽  
Connective Tissue Disorder ◽  
Peyronie’S Disease ◽  
Penile Curvature ◽  
Age Group ◽  
History Of ◽  
Peyronie's Disease ◽  
Symptoms And Signs

Background: Peyronie’s disease is a localised connective tissue disorder that involves the tunica albuginea of the penis. Although long recognised as an important clinical entity of the male genitalia, the aetiology of this disease has remained poorly understood. Methods: The epidemiology and clinical presentation of Peyronie’s disease during a 10-year period was evaluated. Results: Forty-two men with Peyronie’s disease from Chandigarh, India were reviewed retrospectively. The prevalence of Peyronie’s patients was 1.97/1000 patients. Their ages ranged from 23 to 70 years. Most of them presented during the early phase of the disease. The most common presenting complaint was penile curvature in 34 (80.95%) followed by pain on erection in 28 (66.66%). History of penile trauma was revealed by four (9.52%) patients. Among the risk factors, hypercholesterolemia (60%), hypertension (33.3%) and asymptomatic hyperuricemia (28.34%) were the most common. Twenty-two patients with Peyronie’s disease were studied by ultrasonography. Ultrasonogram was more accurate than clinical assessment in delineating the extent of lesions. In one-third of the patients, sonography demonstrated the plaques to be more extensive than had been detected by clinical examination. Conclusions: The clinical symptoms and signs in our study were, in general, similar to those found in the previous studies. Higher incidence of hypertension and diabetes in patients with Peyronie’s disease may also be to an extent due to patients being in an older age group.

Study of the Changes in Collagen of the Tunica Albuginea in Venogenic Impotence and Peyronie's Disease

1992 ◽  
Vol 21 (1) ◽  
pp. 48-51 ◽  
Author(s):  
Po-Hui Chiang ◽  
Chin-Pei Chiang ◽  
Meng-Ru Sheri ◽  
Chun-Hsiung Huang ◽  
Chii-Jye Wang ◽  
...  
Keyword(s):  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

119 Outcomes of Tunica Albuginea Plication for Peyronie's Disease with Limited Use of Permanent Suture

2017 ◽  
Vol 14 (2) ◽  
pp. e45
Author(s):  
D. Papagiannopoulos ◽  
J. Phelps ◽  
E. Yura ◽  
L. Levine
Keyword(s):  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Peyronie's Disease

scholarly journals US Imaging in Peyronie's Disease

2012 ◽  
Vol 2 ◽  
pp. 63 ◽  
Author(s):  
Kiriaki Kalokairinou ◽  
Charalampos Konstantinidis ◽  
Marilena Domazou ◽  
Theodoros Kalogeropoulos ◽  
Prodromos Kosmidis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Imaging Modality ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Low Risk ◽  
Penile Curvature ◽  
Appropriate Treatment ◽  
Peyronie's Disease ◽  
Non Palpable Lesions

The aim of this study is to assess the role of ultrasound (US) in Peyronie's Disease (PD). PD is a psychologically and physically devastating disorder that manifests in middle-aged men. Fibrous inelastic plaques in the tunica albuginea, result in palpable penile scar in the flaccid condition and cause painful erections and penile deformity, including penile curvature, hinging, narrowing, and shortening of penis. Penile deformity is the most common (52%) first symptom of PD and is present in 94% of affected men. US is the primary imaging modality of choice due to its easy availability, low risk, and ability to image and quantify both calcified and soft tissue elements of PD. US provides identification of smaller and non-palpable lesions and shows the extent of fibrosis. Detection of calcifications within the plaque suggests stabilization of the disease and provides information useful to select patients for appropriate treatment.

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