scholarly journals Changing Interdigestive Migrating Motor Complex in Rats under Acute Liver Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-7
Author(s):  
Mei Liu ◽  
Su-Jun Zheng ◽  
Weihong Xu ◽  
Jianying Zhang ◽  
Yu Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Gastrointestinal Motility ◽  
Acute Liver Injury ◽  
Migrating Motor Complex ◽  
Phase Iii ◽  
Important Indicator ◽  
Motor Complex ◽  
Gastrointestinal Motility Disorder ◽  
Interdigestive Migrating Motor Complex ◽  
Normal Controls

Gastrointestinal motility disorder is a major clinical manifestation of acute liver injury, and interdigestive migrating motor complex (MMC) is an important indicator. We investigated the changes and characteristics of MMC in rats with acute liver injury. Acute liver injury was created byD-galactosamine, and we recorded the interdigestive MMC using a multichannel physiological recorder and compared the indexes of interdigestive MMC. Compared with normal controls, antral MMC Phase I duration was significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The duodenal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury. The jejunal MMC cycle and MMC Phases I and IV duration were significantly prolonged and MMC Phase III duration was significantly shortened in the rats with acute liver injury compared with normal controls. Compared with the normal controls, rats with acute liver injury had a significantly prolonged interdigestive MMC cycle, related mainly to longer MMC Phases I and IV, shortened MMC Phase III, and MMC Phase II characterized by increased migrating clustered contractions, which were probably major contributors to the gastrointestinal motility disorders.

Micturition is associated with phase III of the interdigestive migrating motor complex in man

2003 ◽  
Vol 98 (1) ◽  
pp. 66-71
Author(s):  
G. Boudewijn C. Vasbinder ◽  
Marc F.J. Stolk ◽  
M.e-Yun Ke ◽  
Rick J.A. Jebbink ◽  
Gerard P. vanBerge Henegouwen ◽  
...  
Keyword(s):  
Migrating Motor Complex ◽  
Phase Iii ◽  
Motor Complex ◽  
Interdigestive Migrating Motor Complex

Effect of insulin-induced hypoglycaemia on antral, pyloric and duodenal motility in fasting subjects

1991 ◽  
Vol 81 (2) ◽  
pp. 281-285 ◽  
Author(s):  
R. Fraser ◽  
J. Fuller ◽  
M. Horowitz ◽  
J. Dent
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Phase I ◽  
Blood Glucose Concentration ◽  
Migrating Motor Complex ◽  
Control Group ◽  
Motor Complex ◽  
Significant Difference ◽  
Interdigestive Migrating Motor Complex ◽  
Pyloric Motility

1. Hyperglycaemia alters gastric motility and delays gastric emptying. By contrast, there is little information regarding the effect of sub-normal blood glucose concentrations on gastric and, in particular, pyloric motility, although limited data suggest that hypoglycaemia is associated with accelerated gastric emptying despite an apparently increased basal pyloric pressure. 2. To determine the effects of hypoglycaemia on pyloric motility, we compared the effects of an intravenous injection of insulin (0.15 units/kg) with those of a placebo injection of saline in eight healthy human volunteers during phase I of the interdigestive migrating motor complex. 3. All subjects developed profound hypoglycaemia (mean blood glucose concentration 1.6 mmol/l compared with 4.0 mmol/l in the control group). 4. There was no significant difference in the number of antral (9 versus 7, P = 0.34), pyloric (3 versus 0, P = 0.31) or duodenal (21 versus 13, P = 0.42) pressure waves or in the basal pyloric pressure (0.3 mmHg versus 0.1 mmHg, P = 0.37) in the 45 min after insulin injection (hypoglycaemia) when compared with the 45 min after saline injection (euglycaemia). In both the euglycaemic and hypoglycaemic studies there was a time-dependent increase in the numbers of antral and duodenal waves consistent with the expected changes in the interdigestive migrating motor complex. 5. These results indicate that insulin-induced hypoglycaemia has no significant effect on pyloric motility during phase I of the interdigestive migrating motor complex.

Relationship of plasma motilin concentration to fat ingestion, duodenal acidification and alkalinization, and migrating motor complexes in dogs

1981 ◽  
Vol 59 (2) ◽  
pp. 180-187 ◽  
Author(s):  
J. E. T. Fox ◽  
N. S. Track ◽  
E. E. Daniel
Keyword(s):  
Species Difference ◽  
Maximal Activity ◽  
Significant Rise ◽  
Migrating Motor Complex ◽  
Phase Iii ◽  
Complex Activity ◽  
Duodenal Motility ◽  
Motor Complex ◽  
Duodenal Acidification ◽  
Plasma Motilin

Plasma motilin concentrations were measured in dogs following duodenal acidification and alkalinization and gastric instillation of fat. Antral and duodenal motility were recorded concurrently using intraluminal manometry. Alkalinization of the duodenum produced an increase in antral and duodenal motility and a significant rise in plasma motilin. Alkaline infusions at 5 mL/min into the duodenum initiated phase III of a migrating motor complex both in the antrum and in the duodenum. Duodenal acid infusions produced no change in plasma motilin concentrations while inhibiting antral motility and stimulating duodenal motility for the duration of the infusion. Gastric instillation of 60 g fat produced a 25% increase above basal motilin levels at 50 min after instillation. Motilin levels monitored during spontaneous migrating motor complexes showed peak motilin levels occurring during maximal activity of the antral duodenal region in seven out of nine motor complexes examined but motilin peaks also occurred without migrating complexes being present in this area and, as well, complexes occurred when motilin was undetectable. These results taken together with our other studies in man confirm that a true species difference exists between man and dog in the hormonal motor response to duodenal alkalinization. Although a relationship appears to exist between the appearance of maximal migrating motor complex activity in the gastroduodenal area and plasma motilin concentrations in dogs as in humans, the motilin peaks are probably neither necessary nor sufficient to induce phase III activity.

(Gln4)-neurotensin inhibits the interdigestive migrating motor complex in man

1980 ◽  
Vol 1 ◽  
pp. S114
Author(s):  
K. Thor ◽  
Å. Rökaeus ◽  
L. Kager ◽  
K. Folkers ◽  
S. Rosell
Keyword(s):  
Migrating Motor Complex ◽  
Motor Complex ◽  
Interdigestive Migrating Motor Complex

scholarly journals Interdigestive Migrating Motor Complex (IMC) is Co-Regulated With Ghrelin and Motilin in Conscious Dogs

2011 ◽  
Vol 140 (5) ◽  
pp. S-600
Author(s):  
Atsushi Ogawa ◽  
Erito Mochiki ◽  
Mitsuhiro Yanai ◽  
Hiroki Morita ◽  
Yoshitaka Toyomasu ◽  
...  
Keyword(s):  
Migrating Motor Complex ◽  
Conscious Dogs ◽  
Motor Complex ◽  
Interdigestive Migrating Motor Complex

Studies on the interdigestive (migrating) motor complex in man

1978 ◽  
pp. 3-8 ◽  
Author(s):  
G. Vantrappen ◽  
J. Janssens ◽  
J. Hellemans ◽  
N. Christofides ◽  
S. Bloom
Keyword(s):  
Migrating Motor Complex ◽  
Motor Complex ◽  
Interdigestive Migrating Motor Complex

Motor patterns of small intestine determined by closely spaced extraluminal transducers and videofluoroscopy

1987 ◽  
Vol 253 (3) ◽  
pp. G259-G267 ◽  
Author(s):  
H. J. Ehrlein ◽  
M. Schemann ◽  
M. L. Siegle
Keyword(s):  
Small Intestine ◽  
Retrograde Transport ◽  
Migrating Motor Complex ◽  
Phase Iii ◽  
Motor Patterns ◽  
Motor Complex ◽  
Enterogastric Reflux ◽  
Propagating Contractions ◽  
Propagation Velocities

In the canine small intestine several simple (S) and complex (C) patterns of propulsive and nonpropulsive activities were found. The nonpropulsive activity consisted of 1) stationary individual contractions (S) and 2) stationary clusters of contractions (C). Patterns leading to aboral propulsion of luminal contents were 1) propagating contractions (S), 2) propagating power contractions (S), 3) phase III of the migrating motor complex (C), and 4) migrating clusters of contractions (C). The propagation velocities of the propulsive motor patterns differed markedly; they increased in the following order: phase III, migrating clustered contractions, propagating power contractions, propagating contractions. A retrograde transport of luminal contents was produced by two different activities: 1) retrograde propagating contractions (S) and 2) retrograde power contractions (S). They were accompanied with enterogastric reflux.

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