Prognostic Implication of Predominant Histologic Subtypes of Lymph Node Metastases in Surgically Resected Lung Adenocarcinoma

The International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) proposed a new classification for lung adenocarcinoma (AD) based on predominant histologic subtypes, such as lepidic, papillary, acinar, solid, and micropapillary; this system reportedly reflects well outcomes of patients with surgically resected lung AD. However, the prognostic implication of predominant histologic subtypes in lymph nodes metastases is unclear so far. In this study, we compared predominant subtypes between primary lung tumors and lymph node metastatic lesions in 24 patients with surgically treated lung adenocarcinoma with lymph node metastases. Additionally, we analyzed prognostic implications of these predominant histologic subtypes. We observed several discordance patterns between predominant subtypes in primary lung tumors and lymph node metastases. Concordance rates were 22%, 64%, and 100%, respectively, in papillary-, acinar-, and solid-predominant primary lung tumors. We observed that the predominant subtype in the primary lung tumor (HR 12.7,P = 0.037), but not that in lymph node metastases (HR 0.18,P = 0.13), determines outcomes in patients with surgically resected lung AD with lymph node metastases.

Download Full-text

Detection of resistance proteins in matched primary lung tumors and lymph node metastases

Lung Cancer ◽

10.1016/0169-5002(95)96324-o ◽

1995 ◽

Vol 12 (1-2) ◽

pp. 127

Keyword(s):

Lymph Node ◽

Lymph Node Metastases ◽

Lung Tumors ◽

Resistance Proteins ◽

Primary Lung Tumors ◽

Node Metastases

Download Full-text

Frequency of sentinel lymph node metastases in patients with favorable breast cancer histologic subtypes

The American Journal of Surgery ◽

10.1016/s0002-9610(02)01057-7 ◽

2002 ◽

Vol 184 (6) ◽

pp. 492-498 ◽

Cited By ~ 50

Author(s):

Sandra L Wong ◽

Celia Chao ◽

Michael J Edwards ◽

David J Carlson ◽

Alison Laidley ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Lymph Node Metastases ◽

Node Metastases ◽

Histologic Subtypes

Download Full-text

Mutational analysis on gastric, duodenal, bone, and mediastinal lymph node metastases and blood from a case of primary lung adenocarcinoma

OncoTargets and Therapy ◽

10.2147/ott.s167602 ◽

2018 ◽

Vol Volume 11 ◽

pp. 4029-4034

Author(s):

Xin Yang ◽

Rui Chen ◽

Chen Wu ◽

Weiqing Zhao ◽

Mei Ji

Keyword(s):

Lymph Node ◽

Lung Adenocarcinoma ◽

Lymph Node Metastases ◽

Mutational Analysis ◽

Mediastinal Lymph Node ◽

Primary Lung Adenocarcinoma ◽

Node Metastases ◽

Mediastinal Lymph Node Metastases

Download Full-text

A Case of Recurrent Lung Adenocarcinoma with Massive Calcification in Lymph Node Metastases

Haigan ◽

10.2482/haigan.50.816 ◽

2010 ◽

Vol 50 (6) ◽

pp. 816-821

Author(s):

Natsuko Taniguchi ◽

Satoshi Oizumi ◽

Toshiyuki Harada ◽

Atsuo Hattori ◽

Yoshihiro Matsuno ◽

...

Keyword(s):

Lymph Node ◽

Lung Adenocarcinoma ◽

Lymph Node Metastases ◽

Node Metastases

Download Full-text

Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases

Analytical Cellular Pathology ◽

10.1155/2018/8651790 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

Wladimir Gerstenberger ◽

Michaela Wrage ◽

Eeva Kettunen ◽

Klaus Pantel ◽

Sisko Anttila ◽

...

Keyword(s):

Lung Cancer ◽

Lymph Node ◽

Lymph Node Metastases ◽

Lung Tumor ◽

Expression Patterns ◽

Primary Tumors ◽

Caveolin 1 ◽

Cancer Pathogenesis ◽

Significant Difference ◽

Node Metastases

The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of 161 primary tumor samples. 50.7% of squamous cell lung cancer (SCC) tumors showed strong expression of CAV1 in the tumor-associated stromal cells, whereas only 15.1% of adenocarcinomas (AC) showed a strong CAV1 expression (p<0.01). A strong CAV2 stromal expression was found in 46.0% of the lung tumor specimens, with no significant difference between the subtypes. Neither CAV1 nor CAV2 stromal expression was associated with any other clinicopathological factor including survival. When the stromal expression in matched primary tumors and lymph node metastases was compared, both CAV1 and CAV2 expressions were frequently found lost in the corresponding stroma of the lymph node metastasis (40.6%, p=0.003 and 38.4%, p=0.001, resp.). Loss of stromal CAV2 in the lymph node metastases was also significantly associated with earlier death (p=0.011). In conclusion, in contrast to the expression patterns in the tumor tissue of lung cancer, stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis.

Download Full-text