High Rate of Chronic Villitis in Placentas of Pregnancies Complicated by Influenza A/H1N1 Infection

Introduction. Pandemic influenza A/H1N1 infection during pregnancy has a negative impact on several aspects of pregnancy outcome. As yet, no elucidating mechanism has been revealed for these effects. We investigated whether placentas of pregnancies complicated by 2009 influenza A/H1N1 infection demonstrated an increased rate of chronic villitis and whether this villitis was caused by influenza virus.Methods. We performed a cohort study on 145 pregnant outpatients during the 2009-2010 influenza A H1N1 pandemic. The placentas of patients with influenza infection were examined for histologic signs of chronic villitis. In case of villitis, polymerase chain reaction (PCR) on influenza virus was performed on placental tissue.Results. 29 patients had influenza infection. Placentas of 15 of these patients were collected and examined. In 7 cases (47%) chronic villitis was detected. Placental weight and birth weight of the neonates did not differ between cases with and without chronic villitis. In all cases PCR was negative for influenza.Conclusion. In our series, chronic villitis was present in a high proportion of placentas of pregnancies complicated by 2009 influenza A/H1N1 infection. We could not demonstrate the presence of influenza virus in placental tissue.

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Influenza a H1N1 characteristics on hajj occasion 2018 Makkah Region, KSA.

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.11.3900 ◽

2019 ◽

Vol 26 (11) ◽

pp. 1993-1997

Author(s):

Imran Nazir Ahmad ◽

Muhammad Ajmal Farid ◽

Hammad Tufail Chaudhary ◽

Iffat Imran ◽

Rizwan Rasul Khan ◽

...

Keyword(s):

Influenza A ◽

Influenza Infection ◽

Liver Function Tests ◽

Study Data ◽

World Health ◽

H1n1 Infection ◽

Runny Nose ◽

Presenting Symptoms ◽

Function Tests ◽

Influenza A H1n1

Objectives: To see the clinical characteristics and laboratory parameters of influenza A (H1N1) infection on hajj occasion 2018. Introduction: World Health Organization in 2009 declared H1N1 as pandemic, when about 70 countries documented approximately 30,000 cases of H1N1 infection. Saudi Arabia is representing a hot zone for influenza virus epidemics especially during Hajj gathering. Commonly H1N1 infection presents with flue like symptoms. Influenza infection is a major public health threat especially area like Makkah. Study Design: It was observational study. Setting: Done in Security Forces Hospital Makkah. Period: On hajj occasion from July to August 2018. Material and Methods: Total 50 admitted patients in isolation were included in study. Data was collected and analyzed using SPSS version 24. Results: In this study 08% patients had H1N1 +ve out of total patients included in study. Predominantly (75%) were < 14 years with 75% males. The most common presenting symptoms of these patients were Cough (100%), Fever (100%), breathlessness (75%), throat pain (50%), runny nose (75%), headache and lethargy (50%). Twenty five percent patients had hypoxia. Leukopenia was seen in 50% patients and thrombocytopenia was not documented in any patient. Liver Function Tests were deranged in 75% patients and Renal Function Tests were normal in all patients. Number of complications (pneumonia) was 25%. Conclusion: Clinical features and serological markers of influenza A +ve patients were same as reports globally and in KSA.

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Effectiveness of 1 Dose of Influenza A (H1N1) 2009 Monovalent Vaccines in Preventing Reverse-Transcription Polymerase Chain Reaction-Confirmed H1N1 Infection Among School-Aged Children in Maine

The Journal of Infectious Diseases ◽

10.1093/infdis/jis441 ◽

2012 ◽

Vol 206 (7) ◽

pp. 1059-1068 ◽

Cited By ~ 19

Author(s):

A. Uzicanin ◽

M. Thompson ◽

P. Smith ◽

S. S. Chaves ◽

L. Foster ◽

...

Keyword(s):

Polymerase Chain Reaction ◽

Reverse Transcription ◽

Influenza A ◽

H1n1 Infection ◽

Chain Reaction ◽

School Aged Children ◽

Influenza A H1n1 ◽

Polymerase Chain

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The effect of aminoguanidine on acute lung injury induced by influenza A/H1N1/PDM09

Medical academic journal ◽

10.17816/maj34094 ◽

2020 ◽

Vol 20 (2) ◽

pp. 33-44

Author(s):

Andrei G. Aleksandrov ◽

Tatiana N. Savateeva-Lyubimova ◽

Kira I. Stosman ◽

Arman A. Muzhikyan ◽

Konstantin V. Sivak

Keyword(s):

Influenza Virus ◽

Acute Lung Injury ◽

Lung Injury ◽

Influenza A ◽

Structural Changes ◽

Saturation Index ◽

Influenza Infection ◽

Proinflammatory Response ◽

Influenza Virus A ◽

Influenza A H1n1

Background. Acute lung injury is one of severe course of influenza infection with mortality up to 40% of patients, despite on etiological and pathogenetic therapy. The aim of the article to study of the effects of aminoguanidine on correcting on acute lung injury induced by influenza virus A/California/7/09MA (mouse-adapted) (H1N1)pdm09, collection Smorodintsev Research Institute of Influenza. Materials and methods. The study was performed on 95 outbred female mice. The mouse-adapted pandemic influenza virus A/California/7/09MA (H1N1)pdm09 was used for modeling viral infection at a dose of 1 LD50. The mortality was analysed. Levels of advanced glycation end-products (AGEs), proinflammatory cytokines in lung; saturation index and leukocytes marker parameters in blood; pathological and histological studies of lung were performed on 4 and 7 days post infection. Results. Aminoguanidine led to 2-fold decrease in mortality in mice with virus-induced acute lung injury; significantly suppressed the growth of AGEs and proinflammatory cytokine levels in lung; reduced decrease of saturation index and hematological inflammatory markers; decreased level of inflammatory injury in lung tissue. Conclusion. Aminoguanidine relieved virus-induced acute lung injury in mice. These AGEs inhibitor reduced the proinflammatory response and structural changes in respiratory tract epithelial cells induced by reactive carbonyl compounds on cell membrane.

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Acute Encephalitis Syndrome with an Unusual Diagnosis

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmz058 ◽

2019 ◽

Vol 66 (2) ◽

pp. 228-230

Author(s):

Mili Thomas ◽

Kamala Swarnam ◽

Gopika Sekhar Remadevi ◽

A Marthanda Pillai

Keyword(s):

Influenza A ◽

Rare Complication ◽

Normal Liver ◽

Acute Onset ◽

High Rate ◽

H1n1 Infection ◽

Acute Necrotizing Encephalopathy ◽

Influenza A H1n1 ◽

Acute Necrotizing ◽

Intravenous Steroids

Abstract Four-year old boy was admitted with acute onset of fever with seizures and altered sensorium. His mother had history of contact with influenza A H1N1 virus (H1N1) infection. Blood counts, electrolytes, blood sugar and ammonia were normal. Liver enzymes were mildly elevated. CSF study showed elevated protein, normal sugar and no pleocytosis. Cerebrospinal fluid (CSF) viral panel was negative. Magnetic resonance imaging brain was suggestive of acute necrotizing encephalopathy. His throat swab and sputum polymerase chain reaction was positive for H1N1. He was managed with ventilation, intravenous steroids and other supportive measures. At discharge his sensorium improved but had neurological sequelae. We are presenting this case as this is a very rare complication of H1N1 infection with high rate of mortality. Early supportive measures and steroids/intravenous immunoglobulin may save the patient.

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Faculty Opinions recommendation of Paediatric mortality related to pandemic influenza A H1N1 infection in England: an observational population-based study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7219957.7468055 ◽

2010 ◽

Author(s):

Simon Nadel ◽

Ajanta Kamal

Keyword(s):

Pandemic Influenza ◽

Influenza A ◽

Population Based ◽

H1n1 Infection ◽

Population Based Study ◽

Influenza A H1n1

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Influenza: An Emerging and Re-emerging Public Health Threat in Nepal

Annals of Clinical Chemistry and Laboratory Medicine ◽

10.3126/acclm.v3i2.20737 ◽

2018 ◽

Vol 3 (2) ◽

pp. 1-2

Author(s):

Bishnu Prasad Upadhyay

Keyword(s):

Influenza Virus ◽

Influenza A ◽

Winter Season ◽

Emerging Infectious Diseases ◽

Influenza Viruses ◽

Influenza B ◽

Influenza A Viruses ◽

Influenza A H1n1 ◽

New Variant ◽

Seasonal Epidemics

Influenza virus type A and B are responsible for seasonal epidemics as well as pandemics in human. Influenza A viruses are further divided into two major groups namely, low pathogenic seasonal influenza (A/H1N1, A/H1N1 pdm09, A/H3N2) and highly pathogenic influenza virus (H5N1, H5N6, H7N9) on the basis of two surface antigens: hemagglutinin (HA) and neuraminidase (NA). Mutations, including substitutions, deletions, and insertions, are one of the most important mechanisms for producing new variant of influenza viruses. During the last 30 years; more than 50 viral threat has been evolved in South-East Asian countriesof them influenza is one of the major emerging and re-emerging infectious diseases of global concern. Similar to tropical and sub-tropical countries of Southeast Asia; circulation of A/H1N1 pdm09, A/H3N2 and influenza B has been circulating throughout the year with the peak during July-November in Nepal. However; the rate of infection transmission reach peak during the post-rain and winter season of Nepal.

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Nosocomial Influenza in a Pediatric Hospital: Comparison of Rates of Seasonal and Pandemic 2009 Influenza A/H1N1 Infection

Infection Control and Hospital Epidemiology ◽

10.1086/664046 ◽

2012 ◽

Vol 33 (3) ◽

pp. 292-294 ◽

Cited By ~ 2

Author(s):

Gholamabbas Amin Ostovar ◽

Nina Kohn ◽

Karl O. A. Yu ◽

Susan Nullet ◽

Lorry G. Rubin

Keyword(s):

Influenza A ◽

Infect Control Hosp ◽

H1n1 Infection ◽

Pediatric Hospital ◽

Children's Hospital ◽

Influenza A H1n1 ◽

Children’S Hospital ◽

Hospital Comparison

The rates of nosocomial seasonal (January 2008 to March 2009) and 2009 A/H1N1 (April 2009 to December 2010) influenza infections in a children's hospital were compared. Droplet precautions were used. The rates were similar during both periods, suggesting that use of droplet precautions did not result in a higher rate of influenza A/H1N1 infection.Infect Control Hosp Epidemiol 2012;33(3):292-294

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