scholarly journals Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Zhang ◽  
Huanxin Meng ◽  
Li Xu ◽  
Li Zhang ◽  
Dong Shi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gingival Crevicular Fluid ◽  
Smoking Status ◽  
Binding Protein ◽  
Aggressive Periodontitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Vitamin D Binding Protein ◽  
Protein Levels ◽  
Crevicular Fluid

Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP), in comparison to healthy controls, with the goal of elucidating the relationship between DBP and GAgP. Fifty-nine GAgP patients and 58 healthy controls were recruited for the study; clinical parameters of probing depths (PD), bleeding index, and attachment loss (AL) were recorded. DBP levels were measured by enzyme-linked immunosorbent assay. From the results, GAgP patients had higher plasma DBP concentrations (P<0.001) but lower GCF DBP concentrations (P<0.001) than healthy controls. In GAgP group, after controlling the potential confounders of age, gender, smoking status, and BMI index, GCF DBP concentrations correlated negatively with PD (P<0.001) and AL (P=0.009). Within the limits of the study, we concluded that decreased GCF DBP level and increased plasma DBP level are associated with periodontitis.

scholarly journals GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Wenli Song ◽  
Xian’e Wang ◽  
Yu Tian ◽  
Xin Zhang ◽  
Ruifang Lu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Aggressive Periodontitis ◽  
Recessive Model ◽  
Strong Linkage Disequilibrium ◽  
Vitamin D Binding Protein ◽  
Protein Levels ◽  
Combined Genotypes ◽  
Gc Gene ◽  
Control Study

Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis.Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed.Results. GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92,p=0.028). GC rs17467825 and rs4588 had strong linkage disequilibrium withr2≥0.8andD′≥0.8. Haplotype (GC rs17467825, rs4588) GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96,p=0.043). In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CCp=0.007; AG+CA versus GG+AAp=0.026).Conclusions. GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis. The association may be acquired through regulating DBP levels. The functions of GC gene and DBP in inflammatory disease need to be further studied.

scholarly journals Serum vitamin D and vitamin-D-binding protein levels in children with chronic hepatitis B

2021 ◽  
Vol 27 (3) ◽  
pp. 255-266
Author(s):  
Cai-Zhi Huang ◽  
Jie Zhang ◽  
Lin Zhang ◽  
Cui-Hua Yu ◽  
Yi Mo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Vitamin D Binding Protein ◽  
Serum Vitamin D ◽  
Protein Levels

scholarly journals Association of vitamin D-binding protein and vitamin D3 with insulin and homeostatic model assessment (HOMA-IR) in overweight and obese females

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Leila Setayesh ◽  
Krista Casazza ◽  
Nariman Moradi ◽  
Sanaz Mehranfar ◽  
Habib Yarizadeh ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Body Composition ◽  
Binding Protein ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Model Assessment ◽  
Vitamin D Binding Protein ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

Abstract Objective Equivocal association the contribution of 25-hydroxyvitamin D (25(OH)D) and the well-accepted role of vitamin D-binding protein (VDBP) on bioavailability of 25(OH)D or its independent roles, has led to possible association of the VDBP in glucose metabolism. This study was conducted to evaluate the relationships among 25(OH)D, VDBP, glucose/insulin metabolism and homeostatic model assessment (HOMA-IR). Blood samples were collected from 236 obese and overweight women. VDBP and 25(OH)D levels, and biochemical parameters were measured using an enzyme-linked immunosorbent assay (ELISA). An impedance fat analyzer was utilized to acquire the body composition. Results Using the multivariate linear regression, a reverse relationship was observed between VDBP and (HOMA-IR), such that women with higher VDBP displayed lower insulin resistance. The relationship was independent of age, body mass index, standardized energy intake and physical activity (p = 0.00). No significant relationship between 25(OH)D levels, FBS, body composition or insulin resistance were observed (p > 0.2). Current study observed that higher level of VDBP may be associated with lower levels of insulin and HOMA-IR, thus the evaluation of VDBP in diverse population groups seems to have significant clinical value in evaluating the prevalence of DM or early stage of glucose intolerance.

Transcortin and vitamin D-binding protein levels in mouse serum

1986 ◽  
Vol 109 (2) ◽  
pp. 141-147 ◽  
Author(s):  
D. Faict ◽  
P. De Moor ◽  
R. Bouillon ◽  
W. Heyns ◽  
H.-J. Heiniger ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sex Difference ◽  
Binding Protein ◽  
Strain Difference ◽  
Mouse Strains ◽  
Mouse Serum ◽  
Adult Males ◽  
Vitamin D Binding Protein ◽  
Protein Levels ◽  
The Mean

ABSTRACT The influence of age, sex and strain on the serum concentration of transcortin (corticosteroid-binding globulin) and vitamin D-binding protein (DBP) in mice was investigated. The effect of age was studied in two strains, C57BL/6JPfd and BALB/cmHeAPfd. The concentration of transcortin and DBP increased with age. In young animals the concentration of each protein showed a significant strain difference, which disappeared in older mice for DBP, but not for transcortin. In 7-day-old animals, no sex difference was observed for either protein, but in older animals a clear sex difference was found for transcortin. Adult males tended to have somewhat higher levels of DBP than adult females, but this difference was significant only on day 70. The variation in transcortin and DBP levels was further investigated in a large number of mouse strains. The DBP concentration did not markedly vary among strains (5·98–9·65 μmol/l in males and 5·08–8·85 μmol/l in females). Transcortin, however, showed marked strain variations, ranging from 0·72 to 2·06 μmol/l in males and from 1·02 to 4·55 μmol/l in females and there was a significant correlation (r= 0·66, n= 26, P<0·001) between the mean transcortin levels in males and females of different strains. Interstrain variation was much higher than intrastrain variation or variation among related strains, suggesting that the transcortin concentration is largely controlled by genetically determined factors. There was a significant correlation (r= 0·82, n = 9, P<0·01) between the mean corticosterone and transcortin concentrations (measured at 21.00 h). Consequently, differences in the free corticosterone levels in the serum of various mouse strains were smaller than the differences in the total corticosterone concentrations. The affinity of transcortin for corticosterone was similar in all but one strain; however, transcortin of the RIIIS/J strain showed a lower affinity for corticosterone. J. Endocr. (1986) 109, 141–147

scholarly journals Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226215
Author(s):  
Betânia Rodrigues Santos ◽  
Nathália Cruz Costa ◽  
Thais Rasia Silva ◽  
Karen Oppermann ◽  
Jose Antonio Magalhães ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Gene Polymorphisms ◽  
Binding Protein ◽  
Southern Brazil ◽  
Vitamin D Binding Protein ◽  
Protein Levels
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