scholarly journals IVS1 −397T>C Estrogen ReceptorαPolymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Monika Ryba-Stanisławowska ◽  
Karolina Rybarczyk-Kapturska ◽  
Agnieszka Brandt ◽  
Małgorzata Myśliwiec ◽  
Jolanta Myśliwska
Keyword(s):  
Type 1 Diabetes ◽  
Estrogen Receptor ◽  
Inflammatory Response ◽  
Th17 Cells ◽  
Microvascular Complications ◽  
Estradiol Level ◽  
Low Grade ◽  
Serum Estradiol ◽  
Serum Estradiol Level

Purpose. The study aimed to investigate the influence of estrogen receptorα(ER-α) genotypes on inflammatory response and development of microvascular complications in girls with type 1 diabetes.Methods. 152 young regularly menstruating girls with diagnosed type 1 diabetes and 84 young, healthy menstruating girls were recruited. ER-αgenotyping was carried out by PCR. Serum concentrations of 17β-estradiol, as well as IL-6, TNF-α, VEGF, and IL-10, were measured. CD4+Foxp3+TH17 cells were isolated and analyzed by flow cytometry.Results. Type 1 diabetic girls carrying TT genotype were characterized by the lowest serum estradiol level and IL-10 and highest IL-6, TNF-α, and VEGF. The association between the level of certain cytokine and the genetic variant of estrogen receptorαpolymorphism was analyzed. Frequencies of CD4+Foxp3+TH17 cells were also enhanced in TT bearing girls with type 1 diabetes and correlated with the level of analyzed cytokines. In addition, the correlation between serum estradiol level and cytokine concentrations was observed.Conclusions. We propose that TT variant of estrogen receptorαpolymorphism may be associated with enhanced inflammatory response, which in turn may lead to acceleration of diabetic retino- and nephropathy in girls with type 1 diabetes. This finding may help the physicians to predict the onset and progression of diabetic microvascular complications.

Assessment of the prevalence of type 1 diabetes microvascular complications in young adults in the repablic of Belarus with regard to the duration of the disease

2017 ◽  
Author(s):  
Yuliya Dydyshka ◽  
Alla Shepelkevich ◽  
Vladislav Yurkovets ◽  
Elena Brutskaya-Stempkovskaya ◽  
Marina Mantachik
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Microvascular Complications

38-LB: Discovery Analysis of MicroRNAs (miRs) Associated with Microvascular Complications in Adults with Type 1 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 38-LB
Author(s):  
ANDRZEJ S. JANUSZEWSKI ◽  
EMMA S. SCOTT ◽  
MUGDHA JOGLEKAR ◽  
LUKE CARROLL ◽  
RYAN FARR ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications

scholarly journals Age at menarche and the risk of diabetic microvascular complications in patients with type 1 diabetes

Diabetologia ◽  
2015 ◽  
Vol 59 (3) ◽  
pp. 472-480 ◽  
Author(s):  
Valma Harjutsalo ◽  
◽  
Christine Maric-Bilkan ◽  
Carol Forsblom ◽  
Per-Henrik Groop
Keyword(s):  
Type 1 Diabetes ◽  
Microvascular Complications ◽  
Age At Menarche ◽  
Diabetic Microvascular Complications

scholarly journals Retinal vascular fractals predict long-term microvascular complications in type 1 diabetes mellitus: the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987)

Diabetologia ◽  
2014 ◽  
Vol 57 (10) ◽  
pp. 2215-2221 ◽  
Author(s):  
Rebecca Broe ◽  
Malin L. Rasmussen ◽  
Ulrik Frydkjaer-Olsen ◽  
Birthe S. Olsen ◽  
Henrik B. Mortensen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Microvascular Complications ◽  
Pediatric Diabetes ◽  
Danish Cohort

scholarly journals INSULIN DEPENDENT DIABETES MELLITUS

2009 ◽  
Vol 16 (02) ◽  
pp. 178-186
Author(s):  
MUHAMMAD USMAN KHURSHID ◽  
MANSOOR-UL-HASSAN ALV I
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Urinary Albumin Excretion ◽  
Microvascular Complications ◽  
Urinary Albumin ◽  
Elevated Plasma ◽  
Albumin Excretion

A i m s & O b j e c t i v e s : To test the hypothesis that an increased plasma concentration of sialic acid, a marker of the acutephaseresponse, is related to the presence of diabetic retinopathy in type 1 diabetes mellitus or Insulin Dependant Diabetes Mellitus (IDDM).R e s e a r c h D e s i g n a n d M e t h o d s : We investigated the relationship between plasma sialic acid concentration and diabetic retinopathy in across-sectional survey of 1,369 people with type 1 diabetes. Subjects were participants in the IDDM Complications Study, which involveddiabetic centers of four different hospitals in Lahore. Results: There was a significantly increasing trend of plasma sialic acid with severityof retinopathy (P < 0.001 in men) and with degree of urinary albumin excretion (P < 0.001 men, P < 0.01 women). Elevated plasma sialicacid concentrations were also associated with several risk factors for diabetic vascular disease: diabetes duration, HbAlc, plasma triglycerideand cholesterol concentrations, waist-to-hip ratio, hypertension and smoking (in men), and low physical exercise (in women). In multiplelogistic regression analysis, plasma sialic acid was independently related to proliferative retinopathy and urinary albumin excretion rate inmen. Conclusions: We concluded that an elevated plasma sialic concentration is strongly related to the presence of microvascularcomplications in type 1 diabetes with retinopathy and nephropathy. Further study of acute-phase response markers and mediators asindicators or predictors of diabetic microvascular complications is therefore justified.

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