Polycystic Ovary Syndrome: Aggressive or Protective Factor for the Retina? Evaluation of Macular Thickness and Retinal Nerve Fiber Layers Using High-Definition Optical Coherence Tomography

Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women.Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography.Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (P=0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (P<0.05). Both the presence of obesity associated with insulin resistance (P=0.037) and glucose intolerance (P=0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (P<0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (P=0.034).Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS.

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Evaluation of the Macula, Retinal Nerve Fiber Layer, and Choroid Thickness in Women With Polycystic Ovary Syndrome Using Spectral-Domain Optical Coherence Tomography

Reproductive Sciences ◽

10.1177/1933719114522523 ◽

2014 ◽

Vol 21 (8) ◽

pp. 1044-1049 ◽

Cited By ~ 6

Author(s):

Gökhan Açmaz ◽

Mustafa Ataş ◽

Ahmet Gülhan ◽

Banu Açmaz ◽

Fatma Ataş ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Polycystic Ovary Syndrome ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Polycystic Ovary ◽

Spectral Domain ◽

Optical Coherence ◽

Fiber Layer ◽

Ovary Syndrome ◽

Nerve Fiber Layer

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Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314803 ◽

2020 ◽

Vol 104 (10) ◽

pp. 1435-1442

Author(s):

Mohamed I Geneid ◽

Janne J Uusitalo ◽

Ilmari L Leiviskä ◽

Ville O Saarela ◽

M Johanna Liinamaa

Keyword(s):

Optical Coherence Tomography ◽

Optic Nerve ◽

Retinal Vessel ◽

Vessel Diameter ◽

Macular Thickness ◽

Optical Coherence ◽

Middle Aged ◽

Macular Volume ◽

Rnfl Thickness ◽

Arteriolar Diameter

AimsStudying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians.MethodsWe collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography.ResultsData from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all).ConclusionsIncreased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases.

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A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

10.35262/jiag.v15i1.17-21 ◽

2019 ◽

Vol 15 (1) ◽

pp. 17-21

Author(s):

Devendra Sharma ◽

Arvind Chauhan ◽

Avisha Mathur

Keyword(s):

Optical Coherence Tomography ◽

Diabetic Retinopathy ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Macular Thickness ◽

Spectral Domain ◽

Diabetic Patients ◽

Optical Coherence ◽

Fiber Layer ◽

Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

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