Oxidative stress markers in women with polycystic ovary syndrome without insulin resistance

2018 ◽  
Author(s):  
Reveka Gyftaki ◽  
Sofia Gougoura ◽  
Nikolaos Kalogeris ◽  
Vasiliki Loi ◽  
George Koukoulis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers

Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring

2013 ◽  
Vol 99 (3) ◽  
pp. 943-950 ◽  
Author(s):  
Georgios Boutzios ◽  
Sarantis Livadas ◽  
Christina Piperi ◽  
Nicolaos Vitoratos ◽  
Christos Adamopoulos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gestational Diabetes ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers ◽  
Diabetes Offspring

scholarly journals Oxidative stress markers and lipid profiles of patients with polycystic ovary syndrome in a Nigerian tertiary hospital

2019 ◽  
Vol 62 (5) ◽  
pp. 335 ◽  
Author(s):  
Chukwunonso Isaiah Enechukwu ◽  
Anaelechi Jude Onuegbu ◽  
Madu Japheth Olisekodiaka ◽  
George Uchenna Eleje ◽  
Joseph Ifeanyichukwu Ikechebelu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Tertiary Hospital ◽  
Lipid Profiles ◽  
Oxidative Stress Markers ◽  
Ovary Syndrome ◽  
Stress Markers

scholarly journals Evaluation of vitamin D status and its correlation with oxidative stress markers in women with polycystic ovary syndrome

2017 ◽  
Vol 15 (6) ◽  
pp. 345-350 ◽  
Author(s):  
Maryam Rahsepar ◽  
Soleiman Mahjoub ◽  
Sedigheh Esmaeilzadeh ◽  
Maryam Kanafchian ◽  
Maryam Ghasemi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Oxidative Stress Markers ◽  
Vitamin D Status ◽  
Ovary Syndrome ◽  
Stress Markers

scholarly journals Increased oxidative stress is associated with insulin resistance and infertility in polycystic ovary syndrome

2016 ◽  
Vol 87 (11) ◽  
pp. 733-738 ◽  
Author(s):  
Alev Özer ◽  
Murat Bakacak ◽  
Hakan Kıran ◽  
Önder Ercan ◽  
Bülent Köstü ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Oxidative Stress in Response to Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome

2019 ◽  
Vol 104 (11) ◽  
pp. 5360-5371 ◽  
Author(s):  
Frank González ◽  
Robert V Considine ◽  
Ola A Abdelhadi ◽  
Anthony J Acton
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Protein Content ◽  
Polycystic Ovary ◽  
Saturated Fat ◽  
Ros Generation ◽  
Ovary Syndrome ◽  
Control Subjects ◽  
Androgen Secretion

Abstract Context Oxidative stress and insulin resistance are often present in polycystic ovary syndrome (PCOS). Objective We determined the effect of saturated fat ingestion on leukocytic reactive oxygen species (ROS) generation, p47phox expression, and circulating thiobarbituric acid–reactive substances (TBARS) in women with PCOS. Design Cross-sectional study. Setting Academic medical center. Patients Twenty women of reproductive age with PCOS (10 lean, 10 with obesity) and 19 ovulatory control subjects (10 lean, 9 with obesity). Main Outcome Measures ROS generation and p47phox mRNA and protein content were quantified in leukocytes, and TBARS was measured in plasma from blood drawn while the subjects were fasting and 2, 3, and 5 hours after saturated fat ingestion. Insulin sensitivity was derived from an oral glucose tolerance test (ISOGTT). Androgen secretion was assessed from blood drawn while the subjects were fasting and 24, 48, and 72 hours after human chorionic gonadotropin (HCG) administration. Results Regardless of weight class, women with PCOS exhibited lipid-induced increases in leukocytic ROS generation and p47phox mRNA and protein content as well as plasma TBARS compared with lean control subjects. Both PCOS groups exhibited lower ISOGTT and greater HCG-stimulated androgen secretion compared with control subjects. The ROS generation, p47phox, and TBARS responses were negatively correlated with ISOGTT and positively correlated with HCG-stimulated androgen secretion. Conclusion In PCOS, increases in ROS generation, p47phox gene expression, and circulating TBARS in response to saturated fat ingestion are independent of obesity. Circulating mononuclear cells and excess adipose tissue are separate and distinct contributors to oxidative stress in this disorder.

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