Relation between retinal vessel diameter and posterior segment optical coherence tomography variables in middle-aged Caucasians: the Northern Finland Birth Cohort Eye Study

2020 ◽  
Vol 104 (10) ◽  
pp. 1435-1442
Author(s):  
Mohamed I Geneid ◽  
Janne J Uusitalo ◽  
Ilmari L Leiviskä ◽  
Ville O Saarela ◽  
M Johanna Liinamaa
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Retinal Vessel ◽  
Vessel Diameter ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Middle Aged ◽  
Macular Volume ◽  
Rnfl Thickness ◽  
Arteriolar Diameter

AimsStudying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians.MethodsWe collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were assessed by optical coherence tomography.ResultsData from 2155 persons were analysed. A larger RVD was associated with a thicker macula and increased macular volume; each SD increase in average macular thickness and volume was associated with a 3.28 µm and a 3.19 µm increase in arteriolar diameter and a 5.10 µm and a 5.08 µm increase in venular diameter, respectively (p<0.001 for all). A larger rim area, greater GC-IPL and RNFL thicknesses were associated with larger RVD; each SD increase in rim area, GC-IPL thickness and RNFL thickness was associated with a 1.21 µm, 2.68 µm and a 3.29 µm increase in arteriolar diameter and a 2.13 µm, 4.02 µm and 5.04 µm increase in venular diameter, respectively (p<0.001 for all).ConclusionsIncreased macular thickness, macular volume, GC-IPL thickness, RNFL thickness and optic nerve rim area were associated with larger RVDs in all subjects. This study clarified the anatomical correlations between both macular and ONH parameters with RVD for middle-aged Caucasians; these can represent a basis for further studies investigating the vascular aetiology of eye diseases.

scholarly journals Normal Reference Ranges of Optical Coherence Tomography Parameters in Children

Folia Medica ◽  
2020 ◽  
Vol 62 (2) ◽  
pp. 338-344
Author(s):  
Silviya Krumova ◽  
Nelly Sivkova ◽  
Vassil Marinov ◽  
Desislava Koleva-Georgieva ◽  
Desislava Voynikova
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Chamber ◽  
Axial Length ◽  
Anterior Chamber Depth ◽  
Macular Thickness ◽  
Reference Ranges ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Macular Volume ◽  
Rnfl Thickness

Aim: To measure the macular thickness, macular volume and peripapillary retinal nerve fiber layer (RNFL) in healthy Caucasian chil&shy;dren using spectral domain optical coherence tomography (SDOCT) and analyze the correlation of these values with age, refraction, and biometric measurements. Materials and methods: In this cross-sectional study, we recruited 270 healthy children (150 female and 120 male) aged 6 to 17 years with no ocular abnormalities. All children underwent a detailed eye examination. The measurements were obtained using a SDOCT device (SOCT Copernicus REVO). Main outcome measures were macular thickness, macular volume and RNFL thickness. Their correlations with age, refractive error, anterior chamber depth (ACD) and axial length (AL) was analyzed. Right eyes of all subjects were selected for analysis. Results: In this study group (mean age 10.70&plusmn;2.82 years), the average peripapillary RNFL thickness was 117.11&plusmn;9.15 &mu;m, the central macular thickness was 232.10&plusmn;15.81 &mu;m, the average macular thickness was 286.70&plusmn;9.82 &mu;m, and the average macular volume was 8.01&plusmn;0.28 mm&sup3;. The average values for the biometric data were: axial length &ndash; 23.16&plusmn;0.94 mm, anterior chamber depth &ndash; 3.64&plusmn;0.26 mm, the spherical equivalent (SE) value &ndash; +0.81&plusmn;0.58 diopter. Central macular thickness, inner macular thickness (superior, inferior, nasal, temporal quadrants) values, total macular thickness and macular volume were significantly higher in males than in females. We found a positive correlation between central macular thickness, inner nasal macular thickness, outer inferior macular thickness values, and age. Also, we found a significant correlation between the average macular thickness values and the average macular volume values (p<0.0001). RNFL measurements did not correlate with age (p=0.199). Almost all macular parameters were consistently positively cor&shy;related with SE. A significant correlation was also found between the central macular thickness, inner inferior macular thickness, inner nasal macular thickness and the ACD. We found a significant correlation between the average macular thickness, macular volume, inner superior macular thickness, outer macular thickness (superior, inferior, nasal, temporal quadrants) values and the AL. Conclusion: This study found normal reference ranges for RNFL and macular parameters measured by SOCT Copernicus REVO in healthy Caucasian children aged 6-17 years. This normative values could be very useful in early diagnosing and monitoring of optic neuropathy, glaucoma and macular diseases in childhood.

scholarly journals Polycystic Ovary Syndrome: Aggressive or Protective Factor for the Retina? Evaluation of Macular Thickness and Retinal Nerve Fiber Layers Using High-Definition Optical Coherence Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
José Edvan de Souza-Júnior ◽  
Carlos Alexandre de Amorim Garcia ◽  
Elvira Maria Mafaldo Soares ◽  
Técia Maria Oliveira Maranhão ◽  
Telma Maria Araújo Moura Lemos ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Polycystic Ovary Syndrome ◽  
Nerve Fiber ◽  
Polycystic Ovary ◽  
Macular Thickness ◽  
Optical Coherence ◽  
Ovary Syndrome ◽  
Rnfl Thickness

Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women.Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography.Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (P=0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (P<0.05). Both the presence of obesity associated with insulin resistance (P=0.037) and glucose intolerance (P=0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (P<0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (P=0.034).Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS.

scholarly journals Correlation of optic neuritis and retinal nerve fibre thickness using optical coherence tomography in a cohort of multiple sclerosis patients

2016 ◽  
Vol 75 (1) ◽  
Author(s):  
Izanne Roos ◽  
Rajeshree Budhoo ◽  
Linda Visser ◽  
Ahmed I. Bhigjee
Keyword(s):  
Multiple Sclerosis ◽  
Optical Coherence Tomography ◽  
Optic Neuritis ◽  
Nerve Fibre ◽  
Optical Coherence ◽  
Macular Volume ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
History Of ◽  
Multiple Sclerosis Patients

Background: Optical coherence tomography (OCT) is a fast, non-invasive imaging technology that produces 3D, high-resolution images of the retina. Direct visualisation of the retina allows a unique opportunity to study the effects of multiple sclerosis (MS)-associated neurodegeneration on retinal ganglion cells as well as effects of retrobulbar demyelination on axonal and retinal architecture through measurement of retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV). These findings are clinically important as axonal loss is irreversible and correlates with disability.Aim: To determine the role and usefulness of OCT in a local cohort of MS patients.Setting: Neurology Clinic, Inkosi Albert Luthuli Central Hospital, KwaZulu-Natal, South Africa.Methods: Nineteen patients with MS currently being treated with interferon β-1b underwent OCT examination of both eyes. RNFL thickness and macular volume were measured and correlated with clinical disease characteristics, history of optic neuritis and level of disability.Results: Mean RNFL thickness was 77.3 μm with no significant difference in mean RNFL in eyes with a history of optic neuritis (ON) and those without (p = 0.4). Eyes with a history of ON did, however, have significantly thinner RNFL compared with the contralateral eye (p = 0.04). Despite a strong correlation between TMV and RNFL (p = 0.001), a subset of patients with normal RNFL had TMV that was less than 1% of what was expected. There was no correlation between RNFL and disability scores.Conclusion: OCT enables a direct axonal ‘optical biopsy’, for monitoring disease progression and treatment response in MS. RNFL thinning occurs independently of a history of optic neuritis and may represent a chronic optic neuropathy in patients with MS.Keywords: Multiple sclerosis; optical coherence tomography

A Study of Retinal Nerve Fiber Layer Thickness by using Spectral Domain Optical Coherence Tomography in Older Adults with Diabetes Mellitus

2019 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Devendra Sharma ◽  
Arvind Chauhan ◽  
Avisha Mathur
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Macular Thickness ◽  
Spectral Domain ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness

Introduction: Peripapillary retinal nerve fiber layer (RNFL) thinning occurs in the diabetic patients earlier than the detectable diabetic retinopathy. We conducted this study to evaluate the RNFL thickness and macular thickness in elderly diabetic patients using optical coherence tomography in comparison to healthy controls. Material and methods: One fifty study participants were divided in 3 groups (50 each): normal subjects, patients with diabetes with no detectable diabetic retinopathy (NDR) and patients with diabetic retinopathy (DR) of differing severity. The RNFL thickness and macular thickness was measured using spectral-domain optical coherence tomography (SD OCT). Results: The RNFL thickness around the optic disc differed significantly among all the 3 groups and tended to become thinner as the patient develops DR in elderly subjects. The mean, superior-temporal and upper nasal peripapillary RNFL thickness differed among all the 3 groups. We observed that, mean superior, temporal, inferior and nasal RNFL tended to be thinner as the patient develops DR. Conclusion: The RNFL thickness, macular thickness and ganglion cell complex thinning differed significantly between the healthy group and diabetic group without clinical DR. The RNFL thinning (measured by Spectral-domain OCT) is an early neurodegenerative ocular change in diabetic patients even before onset of diabetic retinopathy.

Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy

2021 ◽  
pp. 112067212110497
Author(s):  
Aysin Tuba Kaplan ◽  
Sibel Oskan Yalcın ◽  
Safiye Gunes Sager
Keyword(s):  
Optical Coherence Tomography ◽  
Regression Analysis ◽  
Macular Thickness ◽  
Central Macular Thickness ◽  
Optical Coherence ◽  
Monotherapy Group ◽  
Newly Diagnosed ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Generalized Epilepsy

Objective To evaluate retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and subfoveal choroid thickness (CT) by using optical coherence tomography (OCT) in adolescents with newly diagnosed epilepsy and patients who had been using Na valproate (VPA) for at least 1 year. Methods We examined 60 patients with genetic generalized epilepsy (GGE) aged 8–17 years. Thirty patients with newly diagnosed GGE who were evaluated before the beginning of the therapy and another 30 patients who were chosen from among adolescents with epilepsy using VPA for at least 1 year were included in the study. Results Nasal quadrant RNFL thickness and CMT measurements were significantly lower in the monotherapy group compared with the newly diagnosed group ( p = 0.044 and p = 0.032, respectively). CT measurements were not significantly different between the groups ( p = 0.413). There was a negative correlation in regression analysis between the duration of drug use and RNFL thickness in all quadrants. Conclusion According to our study, we observed thinning of the nasal RNFL and macular thickness in adolescents with epilepsy who were using Na valproate for at least 1 year and that as the duration of use increased, the thinning occurred in all RNFL quadrants. Further studies with larger series are needed to better understand the effects of both epilepsy and VPA on the eye.

scholarly journals Optical Coherence Tomography in Patients with Chiari I Malformation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Michele Figus ◽  
Chiara Posarelli ◽  
Francesco Nasini ◽  
Paolo Perrini ◽  
Mario Miccoli ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Chiari I Malformation ◽  
Nerve Fibers ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Chiari I

Background/Aims. To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls.Methods. Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants.Results. CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P<0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye.Conclusion. A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.

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