scholarly journals Stability and Hopf Bifurcation in a Delayed HIV Infection Model with General Incidence Rate and Immune Impairment

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Fuxiang Li ◽  
Wanbiao Ma ◽  
Zhichao Jiang ◽  
Dan Li
Keyword(s):  
Hiv Infection ◽  
Incidence Rate ◽  
Reproduction Number ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Ctl Response ◽  
General Incidence Rate ◽  
Immune Impairment ◽  
Hiv Infection Model ◽  
The Stability

We investigate the dynamical behavior of a delayed HIV infection model with general incidence rate and immune impairment. We derive two threshold parameters, the basic reproduction numberR0and the immune response reproduction numberR1. By using Lyapunov functional and LaSalle invariance principle, we prove the global stability of the infection-free equilibrium and the infected equilibrium without immunity. Furthermore, the existence of Hopf bifurcations at the infected equilibrium with CTL response is also studied. By theoretical analysis and numerical simulations, the effect of the immune impairment rate on the stability of the infected equilibrium with CTL response has been studied.

scholarly journals Spatiotemporal Dynamics of an HIV Infection Model with Delay in Immune Response Activation

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Mehdi Maziane ◽  
Khalid Hattaf ◽  
Noura Yousfi
Keyword(s):  
Immune Response ◽  
Time Delay ◽  
Hiv Infection ◽  
Chronic Infection ◽  
Reproduction Number ◽  
Infection Model ◽  
Proposed Model ◽  
Hiv Infection Model ◽  
The Stability ◽  
Response Activation

We propose and analyse an human immunodeficiency virus (HIV) infection model with spatial diffusion and delay in the immune response activation. In the proposed model, the immune response is presented by the cytotoxic T lymphocytes (CTL) cells. We first prove that the model is well-posed by showing the global existence, positivity, and boundedness of solutions. The model has three equilibria, namely, the free-infection equilibrium, the immune-free infection equilibrium, and the chronic infection equilibrium. The global stability of the first two equilibria is fully characterized by two threshold parameters that are the basic reproduction number R0 and the CTL immune response reproduction number R1. The stability of the last equilibrium depends on R0 and R1 as well as time delay τ in the CTL activation. We prove that the chronic infection equilibrium is locally asymptotically stable when the time delay is sufficiently small, while it loses its stability and a Hopf bifurcation occurs when τ passes through a certain critical value.

scholarly journals Threshold dynamics and threshold analysis of HIV infection model with treatment

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Zhimin Chen ◽  
Xiuxiang Liu ◽  
Liling Zeng
Keyword(s):  
Hiv Infection ◽  
Time Delays ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Threshold Dynamics ◽  
Positive Equilibrium ◽  
Asymptotically Stable ◽  
Globally Asymptotically Stable ◽  
Immunodeficiency Virus ◽  
Hiv Infection Model

Abstract In this paper, a human immunodeficiency virus (HIV) infection model that includes a protease inhibitor (PI), two intracellular delays, and a general incidence function is derived from biologically natural assumptions. The global dynamical behavior of the model in terms of the basic reproduction number $\mathcal{R}_{0}$ R 0 is investigated by the methods of Lyapunov functional and limiting system. The infection-free equilibrium is globally asymptotically stable if $\mathcal{R}_{0}\leq 1$ R 0 ≤ 1 . If $\mathcal{R}_{0}>1$ R 0 > 1 , then the positive equilibrium is globally asymptotically stable. Finally, numerical simulations are performed to illustrate the main results and to analyze thre effects of time delays and the efficacy of the PI on $\mathcal{R}_{0}$ R 0 .

scholarly journals Bifurcation Analysis of an Age Structured HIV Infection Model with Both Virus-to-Cell and Cell-to-Cell Transmissions

2018 ◽  
Vol 28 (09) ◽  
pp. 1850109 ◽  
Author(s):  
Xiangming Zhang ◽  
Zhihua Liu
Keyword(s):  
T Cells ◽  
Hopf Bifurcation ◽  
Hiv Infection ◽  
Bifurcation Analysis ◽  
Dynamical Behavior ◽  
Infection Model ◽  
Positive Equilibrium ◽  
Semilinear Equations ◽  
Age Structured ◽  
Hiv Infection Model

We make a mathematical analysis of an age structured HIV infection model with both virus-to-cell and cell-to-cell transmissions to understand the dynamical behavior of HIV infection in vivo. In the model, we consider the proliferation of uninfected CD[Formula: see text] T cells by a logistic function and the infected CD[Formula: see text] T cells are assumed to have an infection-age structure. Our main results concern the Hopf bifurcation of the model by using the theory of integrated semigroup and the Hopf bifurcation theory for semilinear equations with nondense domain. Bifurcation analysis indicates that there exist some parameter values such that this HIV infection model has a nontrivial periodic solution which bifurcates from the positive equilibrium. The numerical simulations are also carried out.

Global Dynamics of a HIV Infection Model with Delayed CTL Response and Cure Rate

2013 ◽  
Vol 791-793 ◽  
pp. 1322-1327
Author(s):  
Yan Yan Yang ◽  
Hui Wang ◽  
Zhi Xing Hu ◽  
Wan Biao Ma
Keyword(s):  
Infection Model ◽  
Global Dynamics ◽  
Asymptotically Stable ◽  
Cure Rate ◽  
Globally Asymptotically Stable ◽  
Ctl Response ◽  
Stable Periodic ◽  
Hiv Infection Model ◽  
The Stability ◽  
Viral Infection Model

In this paper, we have considered a viral infection model with delayed CTL response and cure rate. For this model, we have researched the stability of these three equilibriums depend on two threshold parameters and , that is, if , the infected-free equilibrium is locally asymptotically stable; if , the infected equilibrium without CTL response is globally asymptotically stable; and if , the infected equilibrium exists, at he same time, we have found that the time delay can lead to Hopf bifurcations and stable periodic solutions when the is unstable.

scholarly journals Stability Analysis for a Fractional HIV Infection Model with Nonlinear Incidence

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Linli Zhang ◽  
Gang Huang ◽  
Anping Liu ◽  
Ruili Fan
Keyword(s):  
Population Dynamics ◽  
Stability Analysis ◽  
Hiv Infection ◽  
Numerical Simulations ◽  
Fractional Order ◽  
Nonnegative Solution ◽  
Infection Model ◽  
Nonlinear Incidence ◽  
Hiv Infection Model ◽  
The Stability

We introduce the fractional-order derivatives into an HIV infection model with nonlinear incidence and show that the established model in this paper possesses nonnegative solution, as desired in any population dynamics. We also deal with the stability of the infection-free equilibrium, the immune-absence equilibrium, and the immune-presence equilibrium. Numerical simulations are carried out to illustrate the results.

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