scholarly journals Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Deanne Soares ◽  
Nariman Ahmadi ◽  
Oana Crainic ◽  
John Boulas
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rare Complication ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Masses ◽  
Renal Lesions ◽  
Tumour Seeding ◽  
Pathological Assessment

We report a case of tumour seeding caused by percutaneous biopsy of a papillary renal cell carcinoma detected on pathological assessment of the partial nephrectomy specimen in a 50-year-old male. Whilst percutaneous biopsy of renal masses is considered to be safe and can be a valuable tool in the assessment of certain renal lesions, it is not without risks. This rare complication should be taken into consideration before contemplating its use in a patient.

scholarly journals Renal cell carcinoma seeding of a percutaneous biopsy tract

2013 ◽  
Vol 7 (3-4) ◽  
pp. E176-179 ◽  
Author(s):  
Jeffrey K. Mullins ◽  
Ronald Rodriguez
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Cyst ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma ◽  
Intravenous Contrast ◽  
Fuhrman Grade ◽  
To Receive ◽  
Tumour Seeding

We report the case of a 68-year-old male with extension of papillary renal cell carcinoma (Fuhrman grade III) along a percutanous biopsy tract detected at the time of partial nephrectomy. Biopsy was performed to a obtain tissue diagnosis of a complex renal cyst as the patient was unable to receive intravenous contrast for imaging due to a severe allergy. Although biopsy of indeterminate renal lesions can provide valuable diagnostic information, there are inherent risks associated with this procedure. The rare occurrence of tumour seeding should be considered when recommending percutaneous biopsy to a patient with a renal mass.

scholarly journals Renal collision tumour of papillary cell carcinoma and chromophobe cell carcinoma with sarcomatoid transformation: A case report and review of the literature

2014 ◽  
Vol 8 (7-8) ◽  
pp. 536 ◽  
Author(s):  
Zhang Zhiqiang ◽  
Min Jie ◽  
Yu Dexin ◽  
Shi Haoqiang ◽  
Xie Dongdong
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Histopathological Examination ◽  
Papillary Renal Cell Carcinoma ◽  
Local Area ◽  
Simultaneous Occurrence ◽  
Renal Masses ◽  
Collision Tumour ◽  
Eosinophilic Cytoplasm

The simultaneous occurrence of different histological types of adjacent neoplasms in the same organ is called a collision tumour, and rarely occurs in the kidney. A 63-year-old female presented to the urology department with a 1-month history of a painless hematuria. The computed tomography scans of the abdomen revealed 2 heterogeneous incidental right renal masses. The patient underwent radical nephrectomy including lymphadenectomy without adjuvant therapy. Histopathological examination showed a type 2 renal collision tumour of the papillary renal cell carcinoma with eosinophilic cytoplasm and pseudo stratified nuclei on papillary cores, and chromophobe renal cell carcinoma characterized by large polygonal cells with transparent reticulated cytoplasm and prominent cell membranes, which exhibited sarcomatoid transformation in the local area. Routine follow-up demonstrated no localor distant metastasis signs of recurrence at 20 months.

Oncocytic Papillary Renal Cell Carcinoma in the Background of Renal Adenomatosis

2016 ◽  
Vol 25 (1) ◽  
pp. 78-82
Author(s):  
Ji Yeon Kim
Keyword(s):  
Computed Tomography ◽  
Renal Cell Carcinoma ◽  
Literature Review ◽  
Cell Carcinoma ◽  
Rare Disease ◽  
Renal Cell ◽  
Malignant Tumors ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Masses ◽  
Cytological Features

Renal adenomatosis is a rare disease characterized by numerous adenomas in bilateral kidneys. A literature review shows that malignant tumors can arise in this condition. The present case describes an oncocytic papillary renal cell carcinoma (PRCC) arising in renal adenomatosis. A 70-year-old man presented with incidentally identified, multiple right renal masses on computed tomography. Right nephrectomy was performed, and the resected kidney revealed numerous radiologically undetected small nodules additionally. Microscopically, the nodules were papillary neoplasms of variable sizes and cytological features. The largest nodule measured 1.6 cm and was composed of oncocytic cells, meeting the diagnostic criteria of oncocytic PRCC. The smaller nodules of papillary adenomas and tiny lesions showing a single papillary ingrowth were also seen. This case exhibits a spectrum of renal papillary neoplasms in a resected kidney and can be a valuable case in the understanding of tumorigenesis.

scholarly journals Tumour-seeding: a rare complication of ablative therapy for clinically localised renal cell carcinoma

2012 ◽  
Vol 2012 (sep26 1) ◽  
pp. bcr2012006948-bcr2012006948 ◽  
Author(s):  
A. Akhavein ◽  
M. M. Neuberger ◽  
P. Dahm
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Rare Complication ◽  
Ablative Therapy ◽  
Tumour Seeding

scholarly journals A Case Report of Papillary Renal Cell Carcinoma Seeding along a Percutaneous Biopsy Tract

2018 ◽  
Vol 08 (04) ◽  
pp. 139-146
Author(s):  
Christine Busset ◽  
Sandrine Vijgen ◽  
Benoît Lhermitte ◽  
Pu Yan
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Percutaneous Biopsy ◽  
Papillary Renal Cell Carcinoma

scholarly journals Retrospective evaluation of our percutaneous biopsy results of renal masses

2021 ◽  
pp. 131-139
Author(s):  
İlyas Dündar ◽  
Fatma Durmaz ◽  
Sercan Özkaçmaz ◽  
Nazım Abdulkadir Kankılıç ◽  
Abdullah Gül ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Left Kidney ◽  
Lung Squamous Cell Carcinoma ◽  
Percutaneous Biopsy ◽  
Metanephric Adenoma ◽  
Renal Masses ◽  
Study Results ◽  
Kidney Lesions

Objective: In this study, we aim to present the retrospective results of percutaneous biopsies performed on solid kidney lesions in our clinic with the literature. Materials and Methods: In this retrospective descriptive study approved by the ethics committee in our center, the demographic features and histopathological results of 57 patients who had a solid mass in the kidney between 2017-2020 and underwent ultrasonography-guided percutaneous kidney biopsy in our interventional radiology clinic were analyzed from the hospital database. Patients without pathology results were excluded from the study. Results: Our patients consisted of 35 men (61,4%) and 23 women (38,6%). The average age was 59.02±15.33(6-94). We had 1 child and 56 adult patients. 29 of the kidney lesions were located in the left kidney(50,9%) and 28 were located in the right kidney(49,1%). In 44 patients(77.2%) who had malignant pathology; the results were 41 renal cell carcinoma(93.2%), 2 lung squamous cell carcinoma metastasis(4.5%) and 1 primary metastatic pleomorphic adenoma of the salivary gland(2.3%). In a total of 13 patients(22.8%) whose pathology results were benign; the results were 5 oncocytomas(38.5%), 5 angiomyolipoma(38.5%), 2 chronic pyelonephritis(15.4%) and 1 metanephric adenoma(7.6%). Renal cell carcinoma rate was 71.9% among all lesions. Conclusion: Radiological methods may not provide sufficient diagnostic data in the differential diagnosis of solid renal masses.In our study, the rates of benign lesions as a result of percutaneous biopsy were higher compared to the literature. Therefore, we believe that it is remarkable in terms of the importance of preoperative biopsy in solid lesions. Keywords: renal mass, percutaneous biopsy, renal cell carcinoma

scholarly journals Role of multidetector ct in quantitative enhancement- washout analysis of solid renal masses

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Shaimaa Alsayed Abdelmegeed ◽  
Hesham Mohamed Farok ◽  
Medhat Mohamed Refaat ◽  
Tarek Abd Elmeneim Eldiasty
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Multidetector Ct ◽  
Histopathological Diagnosis ◽  
Metanephric Adenoma ◽  
Renal Masses ◽  
Renal Lesions ◽  
Attenuation Value

Abstract Background Enhancement washout technique in solid renal masses using multidetector computed tomography (MDCT) can differentiate different type of lesions. 99 Patients who are presenting with suspected renal masses or renal tumour for staging are included in this study. CT examination are carried out at urology and nephrology centre using MDCT. The attenuation values (Hounsfield Unit) will be assesed for each lesion on the pre enhanced, corticomedullary, nephrographic and delayed phases. Washout ratio will be calculated for each phase of enhancement in comparison to the unenhanced attenuation value. The characteristics of enhancement-washout will be correlated with the final histopathological diagnosis. Results Early enhancement and washout pattern was noted in 54 renal lesions (54.5%) representing 4 types of renal lesions; Oncocytoma (n = 13), clear cell renal cell carcinoma (n = 16), Chromophobe renal cell carcinoma (n = 15) and unclassified renal cell carcinoma (n = 10).Prolonged enhancement pattern was noted 45 lesions (45.4%); PRCC (n = 14), 10 case of lipid poor AML (n = 10), metanephric adenoma (n = 10) and Xp11 RCC (n = 11). High pre-contrast attenuation was noted in Xp 11RCC showing attenuation value 41.7 ± 6.823HU. The highest CMP values were noted in CCRCC (151.9 ± 20.4) followed by oncocytomas (137.6 ± 19.15HU) and then CHRCC (123.6 ± 16.6 HU)while the lowest values were noted in Metanephric adenoma)57.1 ± 17.4HU)and followed by PRCC (59.9 ± 4.8)and followed by lipid poor AML (79.17 ± 13.666) and RCC unclassified (89.06 ± 18.1). Conclusions Four-phase MDCT (the unenhanced, corticomedullary, nephrographic, and excretory phases) evaluate role of MDCT in differentiation of solid renal masses.

Accuracy of renal tumour biopsy for the diagnosis and subtyping of papillary renal cell carcinoma: analysis of paired biopsy and nephrectomy specimens with focus on discordant cases

2019 ◽  
Vol 72 (5) ◽  
pp. 363-367
Author(s):  
Susan Prendeville ◽  
Patrick O Richard ◽  
Michael A S Jewett ◽  
John R Kachura ◽  
Joan M Sweet ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Papillary Renal Cell Carcinoma ◽  
Renal Tumour ◽  
Renal Masses ◽  
Molecular Features ◽  
Tumour Biopsy

AimsRenal tumour biopsy (RTB) is increasingly recognised as a useful diagnostic tool in the management of small renal masses, particularly those that are incidentally found. Intratumoural heterogeneity with respect to morphology, grade and molecular features represents a frequently identified limitation to the use of RTB. While previous studies have evaluated pathological correlation between RTB and nephrectomy, no studies to date have focused specifically on the role of RTB for the diagnosis of papillary renal cell carcinoma (PRCC) and its further subclassification into clinically relevant subtypes.MethodsThis single-institution study evaluated 60 cases of PRCC for concordance between RTB and nephrectomy with respect to diagnosis, grading and subtyping (type 1/type 2).ResultsWe observed 93% concordance (55 of 59 evaluable cases) between RTB and nephrectomy for the diagnosis of PRCC, although seven tumours (12%) were undergraded on RTB. Subtyping of PRCC on RTB was concordant with nephrectomy in 89% of cases reported as type 1 PRCC on RTB (31/35), but only 40% of cases reported as type 2 PRCC on RTB (4/10). Morphological misclassification of PRCC on RTB was most likely to occur in tumours showing a solid growth pattern. Discordant PRCC subtyping most often occurred in tumours with eosinophilia/oncocytic change.ConclusionThere was good concordance between RTB and nephrectomy for the primary diagnosis of PRCC. Although further subtyping of PRCC can aid therapeutic stratification, this can be challenging on RTB and tumours with overlapping or ambiguous features are best reported as PRCC not otherwise specified pending development of more robust methods to facilitate definitive subclassification.

Histologic Heterogeneity of Extirpated Renal Cell Carcinoma Specimens: Implications for Renal Mass Biopsy

2020 ◽  
Vol 7 (3) ◽  
pp. 20-25
Author(s):  
Lauren Nahouraii ◽  
Jordan Allen ◽  
Suzanne Merrill ◽  
Erik Lehman ◽  
Matthew Kaag ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Renal Mass ◽  
Tumor Stage ◽  
High Grade ◽  
Renal Masses ◽  
Histologic Heterogeneity ◽  
Adequate Sampling ◽  
Renal Mass Biopsy

Pathologic characteristics of extirpated renal cell carcinoma (RCC) specimens <7  cm were reviewed to get better information on technical nuances of renal mass biopsy (RMB). Specimens were stratified according to tumor stage, nuclear grade, size, histology, presence of lymphovas-cular invasion (LVI), necrosis, and sarcomatoid features. When considering pT1 (0–7 cm) tumors pT1b (4–7 cm), RCC masses were more likely to have necrosis (43% vs 16%, P < 0.001), LVI (6% vs 2%, P = 0.024), high-grade nuclear elements (29% vs 17%, P < 0.001), and sarcomatoid features (2% vs 0%, P = 0.006) compared with pT1a (0–4 cm) tumors. Additionally, pT3a tumors were more highly associated with necrosis (P = 0.005), LVI, sarcomatoid features, and high-grade disease (P for all < 0.001) when compared to pT1 masses. For masses <4 cm, pT3a cancers were more likely to demonstrate necrosis (38% vs 16%, P < 0.001), LVI (10% vs 2%, P = 0.037), high-grade nuclear elements (31% vs 17%, P = 0.05), and sarcomatoid features (3% vs 0%, P = 0.065) compared to pT1a tumors. Similarly, for masses 4–7 cm, pathologic T3a tumors were significantly more likely to have sarcomatoid features (16% vs 2%, P < 0.001) and LVI (28% vs 6%, P < 0.001) compared to pT1b tumors. In summary, pT3a tumors and those RCC masses >4 cm exhibit considerable histologic heterogeneity and may harbor elements that are not easily appreciated with limited renal sampling. Therefore, if RMB is considered for renal masses greater than 4 cm or those that abut sinus fat, a multi-quadrant biopsy approach is necessary to ensure adequate sampling and characterization of the mass.

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