Clinical Outcome of Hypertensive Uveitis

Purpose. To review the clinical outcome of patients with hypertensive uveitis.Methods. Retrospective review of uveitis patients with elevated intraocular pressure (IOP) > 25 mmHg and >1-year follow-up. Data are uveitis type, etiology, viral (VU) and nonviral uveitis (NVU), IOP, and medical and/or surgical treatment.Results. In 61 patients, IOP values are first 32.9 mmHg (SD: 9.0), highest 36.6 mmHg (SD: 9.9), 3 months after the first episode 19.54 mmHg (SD: 9.16), and end of follow-up 15.5 mmHg (SD: 6.24). Patients with VU (n=25) were older (50.6 y/35.7 y,p=0.014) and had more unilateral disease (100%/72.22% p=0.004) than those with NVU (n=36). Thirty patients (49.2%) had an elevated IOP before topical corticosteroid treatment. Patients with viral uveitis might have higher first elevated IOP (36.0/27.5 mmHg,p=0,008) and maximal IOP (40.28/34.06 mmHg,p=0.0148) but this was not significant when limited to the measurements before the use of topical corticosteroids (p=0.260and 0.160). Glaucoma occurred in 15 patients (24.59%) and was suspected in 11 (18.03%) without difference in viral and nonviral groups (p=0.774).Conclusion. Patients with VU were older and had more unilateral hypertensive uveitis. Glaucoma frequently complicates hypertensive uveitis. Half of the patients had an elevated IOP before topical corticosteroid treatment.

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Minimally Invasive Surgery for Intraocular Lens Removal and Intrascleral Intraocular Lens Fixation with Trabeculectomy in a Patient with Dislocated Intraocular Lens and Elevated Intraocular Pressure

Case Reports in Ophthalmology ◽

10.1159/000511593 ◽

2021 ◽

pp. 538-542

Author(s):

Yuko Mano ◽

Kei Mizobuchi ◽

Tomoyuki Watanabe ◽

Akira Watanabe ◽

Tadashi Nakano

Keyword(s):

Intraocular Pressure ◽

Intraocular Lens ◽

Combined Therapy ◽

Swept Source ◽

Needle Technique ◽

Elevated Intraocular Pressure ◽

Anterior Segments ◽

The Right ◽

End Stage

A 88-year-old female who was being treated for end-stage pseudoexfoliation syndrome was referred to our hospital for treatment of dislocated intraocular lens (IOL) and the elevated intraocular pressure (IOP) and in the right eye (RE). At the first visit to our hospital, best-corrected visual acuity (BCVA) was 0.2 in the RE and 0.02 in the left eye (LE). IOP was 47 mm Hg in the RE and 21 mm Hg in the LE. Slit-lamp examination showed no abnormalities in anterior segments and dislocated IOL in the RE. Fundus photograph showed optic disc pallor in both eyes. We performed the combined therapy of flanged intrascleral IOL fixation with the double-needle technique and trabeculectomy. Throughout the follow-up period, BCVA slightly improved from 0.2 to 0.4 in the RE. The angle of tilt of the IOL was 6.6, 7.9, and 8.7° as measured by swept-source optical coherence tomography at 1, 4, and 6 months after the surgery, respectively. The IOP remained less than 10 mm Hg without having to administer any other glaucoma medications. Furthermore, any complications associated with the surgery were not confirmed.

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Ahmed valve implantation results in children with uveitic glaucoma

Russian Ophthalmological Journal ◽

10.21516/2072-0076-2021-14-1-30-34 ◽

2021 ◽

Vol 14 (1) ◽

pp. 30-34

Author(s):

L. A. Katargina ◽

E. V. Denisova ◽

I. N. A. Bahaaeddin ◽

M. A. Khrabrova

Keyword(s):

Intraocular Pressure ◽

Surgical Treatment ◽

Hypotensive Effect ◽

Open Angle ◽

Anterior Chamber Angle ◽

Safe Method ◽

Ahmed Valve ◽

Valve Implantation ◽

Chamber Angle

The purpose is to evaluate the effectiveness and safety of Ahmed valve implantation in children with refractory postuveitic glaucoma (PUG).Material and methods. Ahmed valve was implanted to 10 children aged 7 to 17 years (10 eyes) with open-angle or mixed PUG uncompensated even by a maximum antihypertensive mode. Previously, all patients had undergone an average of 2.1 ± 0.9 surgeries aimed at normalizing the intraocular pressure (IOP) (predominantly, sinus trabeculectomy). 6 eyes were pseudophakic, 2 phakic, 2 aphakic. Ahmed valves were implanted according to the generally accepted technique. At the time of surgery IOP was 30.50 ± 4.35 mm Hg on average. The follow-up postsurgical period ranged from 3.9 to 23.6 months (averagely, 14.1 ± 6.5).Results. A stable hypotensive effect of the intervention was achieved in 90 % of cases, of which 3 patients had no hypotensives while 6 patients received hypotensive drugs even though their quantity was significantly smaller than before surgery (1.7 ± 1.49, p=0.028). At the end of the follow-up the average IOP was 18.1 ± 5.34 mm Hg, (significantly lower than before surgery, p = 0.008). During surgery, 1 patient experienced bleeding from the vessels of the anterior chamber angle after paracentesis, which was stopped by tamponade with sterile air. In other cases, the surgery as well as the immediate and distant postoperative period showed no complications.Conclusion. Ahmed valve implantation is an effective and safe method of the surgical treatment of refractory PUG in children and can be recommended in cases when previous antiglaucomatous operations proved ineffective, including patients with pseudophakia and aphakia.

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Intravitreal methotrexate for the treatment of proliferative vitreoretinopathy

BMJ Open Ophthalmology ◽

10.1136/bmjophth-2019-000293 ◽

2019 ◽

Vol 4 (1) ◽

pp. e000293 ◽

Cited By ~ 6

Author(s):

Jeffrey David Benner ◽

David Dao ◽

John W Butler ◽

Kelli I Hamill

Keyword(s):

Adverse Effect ◽

Intraocular Pressure ◽

Retrospective Study ◽

Retinal Detachment ◽

Retrospective Review ◽

Proliferative Vitreoretinopathy ◽

Visual Recovery ◽

Perfluorocarbon Liquid ◽

Superficial Punctate Keratopathy

Background/aimsPreventing and treating proliferative vitreoretinopathy (PVR) remain a serious challenge for vitreoretinal surgeons. PVR is a devastating complication of retinal detachment that results in recurrent detachment and limits visual recovery. At present, there is no effective treatment for PVR.Materials and methodsA retrospective review was performed on a cohort of five consecutive eyes with severe PVR and recurrent retinal detachment that were treated with relaxing retinectomy, extended perfluorocarbon liquid tamponade (4–5 weeks) and a series of intravitreal methotrexate (MTX) injections (100–200 µg/0.05 mL for 10 weeks).ResultsAll five patients remained reattached (100%) with 11–27 months of follow-up (mean = 17.4). 4 eyes recovered ambulatory vision (>20/200) with normal intraocular pressure and non-fibrotic laser scars along with the relaxing retinectomy. The initial patient remained reattached, but only had hand motions vision. The only adverse effect noted was mild superficial punctate keratopathy in one patient.ConclusionThis small, retrospective study suggests that a series of MTX injections may be beneficial for treating complex retinal detachment caused by PVR. Further study is indicated.

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Baseline high levels of complement component 4 predict worse clinical outcome at 1-year follow-up in first-episode psychosis

Brain Behavior and Immunity ◽

10.1016/j.bbi.2020.01.014 ◽

2020 ◽

Vol 88 ◽

pp. 913-915 ◽

Cited By ~ 5

Author(s):

Valeria Mondelli ◽

Marta Di Forti ◽

B. Paul Morgan ◽

Robin M. Murray ◽

Carmine M. Pariante ◽

...

Keyword(s):

Clinical Outcome ◽

First Episode Psychosis ◽

Complement Component ◽

First Episode ◽

Episode Psychosis ◽

Complement Component 4

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Metabolic-inflammatory status as predictor of clinical outcome at 1-year follow-up in patients with first episode psychosis

Psychoneuroendocrinology ◽

10.1016/j.psyneuen.2018.09.005 ◽

2019 ◽

Vol 99 ◽

pp. 145-153 ◽

Cited By ~ 13

Author(s):

Maria Antonietta Nettis ◽

Giulio Pergola ◽

Anna Kolliakou ◽

Jennifer O’Connor ◽

Stefania Bonaccorso ◽

...

Keyword(s):

Clinical Outcome ◽

First Episode Psychosis ◽

First Episode ◽

Inflammatory Status ◽

Episode Psychosis

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P.3.a.013 Insight and clinical outcome in first episode psychosis: 1-year follow-up study

European Neuropsychopharmacology ◽

10.1016/s0924-977x(09)70768-0 ◽

2009 ◽

Vol 19 ◽

pp. S487-S488

Author(s):

C. Morelli ◽

R. Ayesa-Arrióla ◽

J.M. Pelayo-Teran ◽

J.M. Rodriguez-Sanchez ◽

R. Perez-Iglesias ◽

...

Keyword(s):

Clinical Outcome ◽

First Episode Psychosis ◽

First Episode ◽

Follow Up Study ◽

Episode Psychosis

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Surgical Treatment of Prolapse of the Third Eyelid Gland in Dogs using Modified Morgan Pocket Technique

Indian Journal of Animal Research ◽

10.18805/ijar.b-1131 ◽

2019 ◽

Author(s):

R. Yaygingul ◽

Z. Bozkan ◽

Z. Bilgen ªen ◽

B. Kibar Kurt ◽

O. Bulut ◽

...

Keyword(s):

Retrospective Study ◽

Surgical Treatment ◽

Clinical Outcome ◽

Success Rate ◽

Postoperative Period ◽

Clinical Problem ◽

The Third ◽

Unilateral Disease ◽

Percent Success ◽

The Right

The aim of this retrospective study was to evaluate the clinical outcome, complications, recurrence rate, and results of the pocket technique in the treatment of prolapse of the third eyelid gland, cherry eye namely. Thirty eyes of 26 dogs diagnosed with prolapse of the third eyelid gland were included the study. Conjunctivitis and ocular discharges were noticed in the affected eyes. The four cases were (15%) bilateral and twenty-two (85%) were unilateral. Of the dogs with unilateral disease, the affected eye was on the left side in 10 (45%) dogs and the right side in 12 (55%). Eighteen dogs were male and eight were female. Twenty-six dogs, 30 eyes with protrusion of the third eyelid gland were treated using Modified Morgan’s pocket technique. In the postoperative period, the dogs were controlled 3 times with 7 day intervals and no clinical problem was detected. Modified Morgan pocket technique was used with 96.1 percent success rate for the re-positioning of prolapsed gland of the third eyelid in dogs.

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