scholarly journals A Curious Case of Iron-Deficiency Anemia

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Seth Shaffer ◽  
Mayur Brahmania ◽  
Hemant Shah

A 49-year-old Brazilian male presented to the emergency department with a five-day history of abdominal pain, dark stools, and syncope. Physical examination did not reveal any melena on digital rectal examination and there were no stigmata of chronic liver disease. Laboratory results showed hemoglobin of 47 g/L, MCV of 80 fL, and ferritin of 6 ng/mL. Liver enzymes and liver function tests were normal. Abdominal ultrasound showed a cirrhotic liver with splenomegaly and varices suggestive of portal hypertension. His past history was significant for cirrhosis based on a previous variceal bleed but a workup for chronic liver disease was negative and a liver biopsy did not show steatosis, fibrosis, or cirrhosis. A gastroscopy in this admission showed large esophageal varices without high-risk stigmata and no overt bleeding was seen. A colonoscopy was subsequently completed to the terminal ileum and was normal aside from a 5 mm sessile polyp in the descending colon.

The Lancet ◽  
1972 ◽  
Vol 300 (7792) ◽  
pp. 1388-1393 ◽  
Author(s):  
F.J. Dudley ◽  
P.J. Scheuer ◽  
S. Sherlock

2000 ◽  
Vol 32 ◽  
pp. 223
Author(s):  
A. Fasoli ◽  
P. Borro ◽  
F. Botta ◽  
B. Chiarbonello ◽  
P. Durando ◽  
...  

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 467-467
Author(s):  
M BORTOLAMI ◽  
H WALDNER ◽  
C VENTURI ◽  
R CARDIN ◽  
C CARLOTTO ◽  
...  

2016 ◽  
Vol 9 (4) ◽  
Author(s):  
Abuzar Saleem ◽  
Haroon Javed Majid ◽  
Muhammad Tufail

To evaluate the safety and efficacy of laparoscopic cholecystectomy in patients with chronic liver disease. It was a retrospective analysis. The study was conducted at Shaikh Zayed Hospital, Lahore between 1993 and 2002. Out of 656 patients undergoing laparoscopic cholecystectomy during this period, 22(6 male, 16 female) were having chronic liver disease as well. Ultrasonography was mainstay of diagnosis of cholelithiasis while liver function tests, platelet count and prothrombin time were done to evaluate liver status.. Eighteen patients were having Child`s class A while rest were in Child`s class B. Laparoscopic cholecystectomy was successful in 20 patients of chronic liver disease. Liver biopsy and paraumbilical hernia repair were additional procedures performed in 8 patients. Two patients were converted to open cholecystectomy due to bleeding and adhesions. Acute cholecystitis was found in 3 patients while rest were having chronic cholecystitis. Mean operative time was 75.45+/-10.9 minutes and mean hospital stay was 2.81+/-1.1 days. Postoperative complications in the form of wound infection (2 pts), prolonged ileus (2 pts) and port hernia (1 pt) occurred in 5 patients. There was no mortality. Laparoscopic cholecystectomy can be safely performed in patients with mild to moderate chronic liver disease without any additional morbidity.


2020 ◽  
Vol 81 (2) ◽  
pp. 1-8
Author(s):  
Prarthana Thiagarajan ◽  
Jane Chalmers ◽  
Indra N Guha ◽  
Martin W James

By 2020, chronic liver disease will have eclipsed ischaemic heart disease as the leading cause of working life years lost in the UK. As mortality from chronic liver disease continues to rise, the landscape of aetiology has shifted from infectious to non-communicable causes. In parallel with the growing prevalence of obesity and type 2 diabetes, non-alcoholic fatty liver disease is estimated to affect 25% of the UK adult population. Simultaneously, escalating alcohol consumption has fuelled public health and economic concerns regarding its widespread impact on working-age adults. Given that chronic liver disease remains clinically silent until its advanced stages, there is an urgent unmet need to identify affected individuals earlier in the disease process, enabling targeted intervention strategies which may improve prognosis. Robust epidemiological data have shown that liver fibrosis is the strongest predictor of clinically meaningful outcomes, including decompensation, liver cancer and overall mortality. Detecting fibrosis among at-risk individuals, in a manner that is reproducible, non-invasive, safe and cost effective, has become a major challenge of our time. This article addresses the pitfalls of the standard panel of liver function tests, discusses other non-invasive biomarkers and reviews imaging technologies which may revolutionise community-based diagnosis and stratification of chronic liver disease.


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