scholarly journals Stem Cell Imaging: Tools to Improve Cell Delivery and Viability

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Junxin Wang ◽  
Jesse V. Jokerst
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Cell Imaging ◽  
Cell Delivery ◽  
Potential Growth ◽  
Cell Purification ◽  
Cell Harvest ◽  
Multiple Stages ◽  
Cell Implantation

Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and this review describes the role that imaging plays in cell harvest, cell purification, and cell implantation, as well as a discussion of how imaging can be used to assess outcome in SCT. We close with some perspective on potential growth in the field.

scholarly journals Cell Therapy and Bioengineering in Experimental Liver Regenerative Medicine: In Vivo Injury Models and Grafting Strategies

2021 ◽  
Author(s):  
G. Amato ◽  
T. Saleh ◽  
G. Carpino ◽  
E. Gaudio ◽  
D. Alvaro ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Cell Therapy ◽  
Cell Delivery ◽  
Effective Strategies ◽  
Multiple Strategies ◽  
End Stage ◽  
Therapy Strategies ◽  
Injury Models ◽  
Experimental Liver

Abstract Purpose of Review To describe experimental liver injury models used in regenerative medicine, cell therapy strategies to repopulate damaged livers and the efficacy of liver bioengineering. Recent Findings Several animal models have been developed to study different liver conditions. Multiple strategies and modified protocols of cell delivery have been also reported. Furthermore, using bioengineered liver scaffolds has shown promising results that could help in generating a highly functional cell delivery system and/or a whole transplantable liver. Summary To optimize the most effective strategies for liver cell therapy, further studies are required to compare among the performed strategies in the literature and/or innovate a novel modifying technique to overcome the potential limitations. Coating of cells with polymers, decellularized scaffolds, or microbeads could be the most appropriate solution to improve cellular efficacy. Besides, overcoming the problems of liver bioengineering may offer a radical treatment for end-stage liver diseases.

Regenerative medicine and traumatic brain injury: from stem cell to cell-free therapeutic strategies

2021 ◽  
Author(s):  
Lianxu Cui ◽  
Yasmeen Saeed ◽  
Haomin Li ◽  
Jingli Yang
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Stem Cell ◽  
Brain Injury ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Therapeutic Strategies ◽  
Study Data ◽  
Health Concern ◽  
Standardized Treatment

Traumatic brain injury (TBI) is a serious health concern, yet there is a lack of standardized treatment to combat its long-lasting effects. The objective of the present study was to provide an overview of the limitation of conventional stem cell therapy in the treatment of TBI and to discuss the application of novel acellular therapies and their advanced strategies to enhance the efficacy of stem cells derived therapies in the light of published study data. Moreover, we also discussed the factor to optimize the therapeutic efficiency of stem cell-derived acellular therapy by overcoming the challenges for its clinical translation. Hence, we concluded that acellular therapy possesses the potential to bring a breakthrough in the field of regenerative medicine to treat TBI.

An effective strategy of magnetic stem cell delivery for spinal cord injury therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (9) ◽  
pp. 3954-3958 ◽  
Author(s):  
Dmitry Tukmachev ◽  
Oleg Lunov ◽  
Vitalii Zablotskii ◽  
Alexandr Dejneka ◽  
Michal Babic ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Critical Parameters ◽  
Cell Delivery ◽  
Effective Strategy ◽  
Stem Cell Delivery ◽  
Injured Area ◽  
Cord Injury

For cell therapy, the number of transplated cells that reach the injured area is one of the critical parameters.

Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields

2014 ◽  
Vol 173 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Fatemeh Pourrajab ◽  
Mojtaba Babaei Zarch ◽  
Mohammad Baghi Yazdi ◽  
Abolfazl Rahimi Zarchi ◽  
Abbas Vakili Zarch
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Multimodal Therapy ◽  
Therapy Approach ◽  
Factor System ◽  
Stem Cell Growth Factor

scholarly journals Stem Cell Therapy and Regenerative Medicine

2009 ◽  
Vol 84 (10) ◽  
pp. 859-861 ◽  
Author(s):  
Timothy O'Brien ◽  
Frank P. Barry
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Stem Cell Therapy

scholarly journals Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial Infarction

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Michelle R. Santoso ◽  
Phillip C. Yang
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
Regenerative Medicine ◽  
Cell Therapy ◽  
Iron Oxide Nanoparticles ◽  
Stem Cell Therapy ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Stem cell therapy has broad applications in regenerative medicine and increasingly within cardiovascular disease. Stem cells have emerged as a leading therapeutic option for many diseases and have broad applications in regenerative medicine. Injuries to the heart are often permanent due to the limited proliferation and self-healing capability of cardiomyocytes; as such, stem cell therapy has become increasingly important in the treatment of cardiovascular diseases. Despite extensive efforts to optimize cardiac stem cell therapy, challenges remain in the delivery and monitoring of cells injected into the myocardium. Other fields have successively used nanoscience and nanotechnology for a multitude of biomedical applications, including drug delivery, targeted imaging, hyperthermia, and tissue repair. In particular, superparamagnetic iron oxide nanoparticles (SPIONs) have been widely employed for molecular and cellular imaging. In this mini-review, we focus on the application of superparamagnetic iron oxide nanoparticles in targeting and monitoring of stem cells for the treatment of myocardial infarctions.

Critical path in cardiac stem cell therapy: an update on cell delivery

Cytotherapy ◽  
2013 ◽  
Vol 15 (4) ◽  
pp. 399-415 ◽  
Author(s):  
Winston Shim ◽  
Ashish Mehta ◽  
Philip Wong ◽  
Terrance Chua ◽  
Tian Hai Koh
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Critical Path ◽  
Cell Delivery ◽  
Cardiac Stem Cell
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