SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder punctuated by varied multiorgan complications all along the course of its natural history. Lymphoma represents a relatively well-recognized malignant phenomenon associated with lupus. The cause and effect relationships of lymphoma in SLE have been subject to extensive scrutiny with several studies reporting on clinic-pathologic characteristics and risk factors predicting lymphoma development in SLE. However, the pathogenic role of immunosuppressives in SLE-related lymphoma still remains unclear, and indices to help guide diagnosis, prognostication, therapy, and posttreatment monitoring are yet to be established. In this review, we describe 3 SLE patients who developed non-Hodgkin’s lymphoma at different time points of their disease. Through a careful dissection of the aforementioned cases, we intend to apprise readers of the currently available literature surrounding risk factors, management, and prognosis in SLE-related lymphoma. We will also review and discuss the implications of immunosuppressives in SLE-related lymphoma and the role of mycophenolate mofetil in SLE-related primary CNS lymphoma development.

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Treatment of primary CNS lymphoma (PCNSL) following successful treatment of systemic non-Hodgkin’s lymphoma (NHL): a case series

Journal of Neuro-Oncology ◽

10.1007/s11060-013-1085-7 ◽

2013 ◽

Vol 113 (1) ◽

pp. 27-32 ◽

Cited By ~ 3

Author(s):

Marc C. Chamberlain

Keyword(s):

Successful Treatment ◽

Hodgkin’S Lymphoma ◽

Primary Cns Lymphoma ◽

Case Series ◽

Hodgkin's Lymphoma ◽

Cns Lymphoma ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma

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The Role of Surgery in the Clinical Management of Primary Gastrointestinal Non-Hodgkin's Lymphoma

The American Surgeon ◽

10.1177/000313481508101016 ◽

2015 ◽

Vol 81 (10) ◽

pp. 988-994

Author(s):

Ian T. MacQueen ◽

Evan M. Shannon ◽

Aaron J. Dawes ◽

Nora Ostrzega ◽

Marcia M. Russell ◽

...

Keyword(s):

Surgical Resection ◽

Hodgkin’S Lymphoma ◽

Case Series ◽

Disease Free Survival ◽

Hodgkin's Lymphoma ◽

Treatment Modalities ◽

Non Hodgkin’S Lymphoma ◽

Non Hodgkin's Lymphoma ◽

The Impact

Primary gastrointestinal non-Hodgkin's lymphoma (PGINHL) is a heterogeneous family of tumors, with treatment modalities including chemotherapy, surgery, and radiotherapy. Because the role of surgery in PGINHL remains disputed, this study aims to assess the impact of operative resection on survival. We used a pathology database to identify all cases of PGINHL diagnosed at a single academic-affiliated medical center from 1988 to 2013. Demographic and clinical data were abstracted from the medical record. We summarized the clinical courses of patients with PGINHL and then performed a survival analysis to compare overall and disease-free survival, stratified by demographic and clinical variables. We identified 33 patients diagnosed with PGINHL during the study period. Of 29 who subsequently received treatment at the institution, 15 initially underwent chemotherapy, 10 underwent surgical resection, and 4 underwent surgery for other reasons such as diagnosis without resection or management of disease complications. Three patients suffered surgical complications and two of these patients died. We found no difference in overall survival between patients receiving surgical resection and patients managed initially with chemotherapy. This case series supports a continued role for surgical resection in the management of patients with PGINHL, though anticipated benefits should be weighed against the risk of complications.

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