Mycotic Aneurysm after Bacillus Calmette-Guérin Treatment: Case Report and Review of the Literature

Background. Intravesicular Bacillus Calmette-Guérin (BCG) is an effective adjunctive therapy for superficial bladder cancer that has been shown to delay recurrence and progression of disease. Serious side effects are relatively rare but are difficult to diagnosis and commonly overlooked. Case Presentation. We report the case of a patient who was found to have mycotic aortic aneurysms secondary to treatment with BCG after a prolonged course with multiple intervening hospitalizations. Conclusion. Through this report, we discuss our present understanding of BCG infection following treatment and review the literature regarding this particular rare manifestation.

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Transitory Spontaneous Remission of Myelodysplasia in an Elderly Man while Receiving Intravesical Bacillus Calmette-Guérin for Bladder Cancer: A Case Report and Review of the Literature

Case Reports in Hematology ◽

10.1155/2018/9750532 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7

Author(s):

Nigel P. Murray ◽

Cynthia Fuentealba ◽

Isidora Salazar ◽

Aníbal Salazar ◽

Marco Antonio Lopez ◽

...

Keyword(s):

Bladder Cancer ◽

Case Report ◽

Superficial Bladder Cancer ◽

Spontaneous Remission ◽

Bacillus Calmette Guerin ◽

Review Of The Literature ◽

Intravesical Bcg

Myelodysplasia is a clonal disorder characterized by progressive cytopenias. Intravescial BCG is standard immunotherapy for superficial bladder cancer. We present a patient with transfusion-dependent myelodysplasia whose blood counts normalized during treatment with intravesical BCG for bladder cancer. After finishing treatment, the patient became transfusion dependent once more. We discuss possible mechanisms to explain this case report.

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1570: Combined Mitomycin C and Hyperthermia (SYNERGO) for Patients with Superficial Bladder Cancer (SBC) after Bacillus Calmette-Guerin (BCG) Failure

The Journal of Urology ◽

10.1016/s0022-5347(18)31758-0 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 519-519

Author(s):

Ofer Nativ ◽

Renzo Colombo ◽

Dov Engelstein ◽

Ofer N. Gofrit ◽

Thomas Akkad ◽

...

Keyword(s):

Bladder Cancer ◽

Mitomycin C ◽

Superficial Bladder Cancer ◽

Bacillus Calmette Guerin ◽

Bcg Failure

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Granulomatous Hepatitis Following Intra-Vesical Instillation of Bacillus Calmette–Guérin for Treatment of Bladder Cancer

Infectious Disease Reports ◽

10.3390/idr13030057 ◽

2021 ◽

Vol 13 (3) ◽

pp. 611-618

Author(s):

Elsa Alves Branco ◽

Raquel Duro ◽

Teresa Brito ◽

António Sarmento

Keyword(s):

Bladder Cancer ◽

Hepatitis A ◽

Adverse Reactions ◽

Superficial Bladder Cancer ◽

Rare Complication ◽

Immunocompetent Patient ◽

Clinical Suspicion ◽

Bacillus Calmette Guerin ◽

Granulomatous Hepatitis ◽

Appropriate Treatment

Intra-vesical instillation of bacillus Calmette–Guérin (BCG) is an important treatment modality of superficial bladder cancer. It is usually well tolerated, although some adverse reactions can occur. One possible yet rare complication is granulomatous hepatitis, that is thought to be caused either by BCG infection or a hypersensitivity reaction to the bacillus. We present a case of a 79-year-old apparently immunocompetent patient who developed granulomatous hepatitis a few months after BCG administration for bladder cancer immunotherapy. It is important to notice that acid-fast smears and cultures are often negative, and these should not exclude diagnosis nor delay treatment. Our case highlights the importance of clinical suspicion and prompt initiation of appropriate treatment.

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A Low Dose Bacillus Calmette-Guerin Regimen in Superficial Bladder Cancer Therapy: Is it Effective?

The Journal of Urology ◽

10.1016/s0022-5347(17)37707-8 ◽

1991 ◽

Vol 146 (1) ◽

pp. 32-35 ◽

Cited By ~ 143

Author(s):

Francesco Pagano ◽

Pierfrancesco Bassi ◽

Claudio Milani ◽

Agostino Meneghini ◽

Daniele Maruzzi ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Therapy ◽

Low Dose ◽

Superficial Bladder Cancer ◽

Bacillus Calmette Guerin

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Final results from a national multicenter phase II trial of combination bacillus Calmette-Guérin plus interferon α-2B for reducing recurrence of superficial bladder cancer☆

Urologic Oncology Seminars and Original Investigations ◽

10.1016/j.urolonc.2005.11.026 ◽

2006 ◽

Vol 24 (4) ◽

pp. 344-348 ◽

Cited By ~ 158

Author(s):

Fadi N. Joudi ◽

Brian J. Smith ◽

Michael A. O’Donnell

Keyword(s):

Bladder Cancer ◽

Phase Ii ◽

Phase Ii Trial ◽

Superficial Bladder Cancer ◽

Interferon Α ◽

Bacillus Calmette Guerin ◽

Multicenter Phase

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Determination of Bacillus Calmette-Guerin Concentration Integrated in Delivery Materials for Intravesical Infusion Therapy of Superficial Bladder Cancer

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.655-657.1917 ◽

2013 ◽

Vol 655-657 ◽

pp. 1917-1922 ◽

Cited By ~ 1

Author(s):

Cheng Ge Wu ◽

Kang Ning Sun ◽

Ai Min Li ◽

Xiao Ning Sun

Keyword(s):

Bladder Cancer ◽

Reliable Method ◽

Superficial Bladder Cancer ◽

The Other ◽

Infusion Therapy ◽

Bacillus Calmette Guerin ◽

Experiment Study ◽

Characteristic Peak ◽

Integrated Delivery

Purpose: To assess determination of Bacillus Calmette-Guerin(BCG) concentration integrated in delivery materials for intravesical infusion therapy of superficial bladder cancer. Material and Methods: The standard BCG solution was prepared and divided into two groups. One group was measured by spectrophotometer direct, the other group was determined by using enzyme mark instrument after the solution had cultured. The preliminary experiment study on BCG integrated delivery materials was finished by XTT method. Results: The wavelength of the characteristic peak changes with the variety of the concentration measured by spectrophotometer direct. The concentration of BCG which was embeded in integrated delivery materials for intravesical infusion therapy of superficial bladder cancer was linear with absorbance at 450nm by XTT method in the selected range. Conclusions: It is an incorrect way to measure BCG concentration like determining other solutions by the spectrophotometer immediately and direct. It is the simple, rapid and reliable method by XTT method to study on the performance of the BCG concentration integrated in delivery materials for Intravesical infusion therapy of superficial bladder cancer.

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