scholarly journals Persistent Corneal Decompensation due to Anterior Dislocation of Soemmering Ring Cataract

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Travis Peck ◽  
Shruti Aggarwal ◽  
Sandra Johnson
Keyword(s):  
Cataract Surgery ◽  
Open Angle Glaucoma ◽  
Corneal Edema ◽  
Anterior Dislocation ◽  
Surgical Removal ◽  
History Of ◽  
Corneal Decompensation ◽  
Early Surgical Intervention ◽  
Soemmering Ring ◽  
Ring Dislocation

Purpose. We present a case of a patient with Soemmering ring after cataract surgery and a potential complication that can arise as a result of its presence. Observations. A patient with history of ruptured globe status after repair and lensectomy, complicated by aphakic secondary open angle glaucoma, was referred for management of second injury to the same eye. This injury resulted in Soemmering ring dislocation into the anterior chamber. The cortical material caused a significant increase in intraocular pressure and corneal decompensation. Surgical removal of the Soemmering ring and Ahmed glaucoma tube implant was performed with control of intraocular pressures; however corneal edema could not be reversed. Conclusions and Importance. This case report illustrates the serious consequences that can be caused by Soemmering rings without early surgical intervention. Care must be taken to completely remove cortical material during cataract surgery to prevent their formation.

scholarly journals Rhopressa-induced corneal edema: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Matthew J. Chu ◽  
Michael Song ◽  
Trisa Palmares ◽  
Alice Song ◽  
Julia Song
Keyword(s):  
African American Woman ◽  
Open Angle Glaucoma ◽  
Case Reports ◽  
American Woman ◽  
Corneal Edema ◽  
Common Side Effect ◽  
Conjunctival Hyperemia ◽  
Rock Inhibitor ◽  
Unique Case ◽  
History Of

Abstract Background Rhopressa (netarsudil) has recently been added to the arsenal of treatment for open-angle glaucoma. It is an effective norepinephrine transporter and Rho-associated protein kinase (ROCK) inhibitor used to decrease intraocular pressure (IOP), with the most common side effect being conjunctival hyperemia. Case presentation We report a unique case of Rhopressa-induced corneal edema in a 79-year-old African-American woman, which resolved after discontinuation. She had a history of smoking one cigarette per day and did not consume alcohol. She had no history of corneal edema or uveitis. Conclusions Previous case reports have documented patients with Rhopressa-induced corneal edema; however, they have all had a preexisting history of corneal edema or uveitis. We believe that this is a unique case of Rhopressa-induced corneal edema in a relatively healthy eye. While Rhopressa is effective in managing glaucoma, there may be effects of treatment that are still unknown. We will discuss clinical findings of our case, along with a review of previous literature on Rhopressa and novel ROCK inhibitors. We hope that we can add to the existing body of literature and invite further investigation of Rhopressa and ROCK inhibitors and their effects on the cornea.

scholarly journals Effect of Exogenous Alpha-B Crystallin on the Structures and Functions of Trabecular Meshwork Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Hui Xu ◽  
Li Zhu ◽  
Yu Wang ◽  
Yongzhen Bao
Keyword(s):  
Cataract Surgery ◽  
Trabecular Meshwork ◽  
Epithelial To Mesenchymal Transition ◽  
Open Angle Glaucoma ◽  
Mrna Level ◽  
Cell Counting ◽  
Control Group ◽  
Surgical Removal ◽  
Open Angle ◽  
Mesenchymal Transition

Purpose. Secondary open-angle glaucoma may develop as a postoperative complication of early childhood cataract surgery. Its mechanism is poorly understood. Surgical removal of cataracts is typically incomplete, and we estimate that this disease is associated with alpha-B crystallin (CRYAB) secreted from the retained lens material. This study, for the first time, focused on the role of CRYAB in undesired changes of the structures and functions in trabecular meshwork (TM) cells.Methods. Cell proliferation and migration were assessed using a cell counting kit-8 (CCK8) and transwell assay analysis, respectively. Immunofluorescence (IF), quantitative real-time PCR (Rt-qPCR), and Western blot were performed to determine the effect of CRYAB on F-actin, tight junctions, and the expression of epithelial to mesenchymal transition- (EMT-) associated proteins in TM cells.Results. CRYAB promoted proliferation (p<0.0001), migration (p<0.001), and F-actin reorganization in TM cells. There were statistically significant increases in the mRNA and protein levels of zo-1, cadherin-N, and vimentin (allp<0.0001) and cadherin-E decreased (p<0.0001) and the mRNA level of claudin-1 increased (p<0.0001) compared to those of the control group.Conclusion. All of the changes in structures and functions first observed in the TM cells after exposure to CRYAB resembled alterations seen in primary open-angle glaucoma, suggesting that CRYAB might be related to the pathogenesis of secondary open-angle glaucoma after congenital cataract surgery.

scholarly journals Lens-Induced Uveitis Triggered by Intravitreal Injection 40 Years after Primary Congenital Cataract Surgery with Aphakia

2020 ◽  
Vol 11 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Sophia El Hamichi ◽  
Rafael J. Aguilar ◽  
Veronica Kon Graversen ◽  
Aaron S. Gold ◽  
Audina M. Berrocal ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Macular Edema ◽  
Intravitreal Injection ◽  
Congenital Cataract ◽  
Diabetes Mellitus Type 1 ◽  
Surgical Removal ◽  
Primary Vitrectomy ◽  
History Of ◽  
Bilateral Congenital Cataract ◽  
Congenital Cataract Surgery

We report a case of a 42-year-old male with a history of bilateral congenital cataract surgery performed at 2 years of age. The patient was left with aphakia, secondary glaucoma, and a history of diabetic macular edema in the setting of diabetes mellitus type 1. The right eye became prephthisical from his congenital surgical repair, and his left eye presented with an acute pseudo-endophthalmitis developing after the seventh intravitreal injection to treat the macular edema. The eye then presented with decrease in vision, periocular injection, and a diffuse inflammatory reaction focused around the anterior residual lens capsule. The patient underwent surgical removal of the residual capsule and primary vitrectomy repair of the eye, achieving a significant improvement in visual symptoms and recovery of visual and anatomic function.

scholarly journals Nanogel-Facilitated In-Situ Delivery of a Cataract Inhibitor

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1150
Author(s):  
Dixa Gautam ◽  
Michelle G. Pedler ◽  
Devatha P. Nair ◽  
Jonathan Mark Petrash
Keyword(s):  
Cataract Surgery ◽  
Vision Loss ◽  
Effective Means ◽  
Lens Capsule ◽  
Posterior Capsular Opacification ◽  
Surgical Removal ◽  
Visual Disability ◽  
Visual Axis ◽  
Number Of Patients ◽  
Subsequent Degradation

Cataracts are a leading cause of blindness worldwide. Surgical removal of cataracts is a safe and effective procedure to restore vision. However, a large number of patients later develop vision loss due to regrowth of lens cells and subsequent degradation of the visual axis leading to visual disability. This postsurgical complication, known as posterior capsular opacification (PCO), occurs in up to 30% of cataract patients and has no clinically proven pharmacological means of prevention. Despite the availability of many compounds capable of preventing early steps in PCO development, there is currently no effective means to deliver such therapies into the eye for a suitable duration. To model a solution to this unmet medical need, we fabricated acrylic substrates as intraocular lens (IOL) mimics scaled to place into the capsular bag of the mouse lens following a mock-cataract surgery. Substrates were coated with a hydrophilic crosslinked acrylate nanogel designed to elute Sorbinil, an aldose reductase inhibitor previously shown to suppress PCO. Insertion of the Sorbinil-eluting device into the lens capsule at the time of cataract surgery resulted in substantial prevention of cellular changes associated with PCO development. This model demonstrates that a cataract inhibitor can be delivered into the postsurgical lens capsule at therapeutic levels.

scholarly journals Cataract Surgery in Patients with a Previous History of KAMRA Inlay Implantation: A Case Series

2017 ◽  
Vol 6 (1) ◽  
pp. 207-213
Author(s):  
Majid Moshirfar ◽  
Tyler S. Quist ◽  
David F. Skanchy ◽  
Steven H. Linn ◽  
Jordan Desautels ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Previous History ◽  
Case Series ◽  
History Of

scholarly journals A Case of Bilateral Permanent Subluxation of the Lateral Meniscus

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Jun Suganuma ◽  
Tadashi Sugiki ◽  
Yutaka Inoue
Keyword(s):  
Magnetic Resonance ◽  
Knee Joint ◽  
Lateral Meniscus ◽  
Detailed Examination ◽  
Magnetic Resonance Images ◽  
Posterior Segment ◽  
Anterior Dislocation ◽  
Normal Position ◽  
Straight Position ◽  
History Of

We report a case of bilateral, permanent subluxation of the lateral meniscus. To our knowledge, the present case is the first reported description of bilateral irreducible anterior dislocation of the posterior segment of the lateral meniscus. This disorder is characterized by a flipped meniscus sign of the lateral meniscus on sagittal magnetic resonance images of the knee joint, with no history of trauma or locking symptoms. A detailed examination of serial magnetic resonance images of the lateral meniscus can help differentiate this condition from malformation of the lateral meniscus, that is, a double-layered meniscus. We recommend two-stage treatment for this disorder. First, the knee joint is kept in straight position for 3 weeks after the lateral meniscus is reduced to the normal position. Second, if subluxation of the lateral meniscus recurs, meniscocapsular suture is then performed. Although subluxation of the lateral meniscus without locking symptoms is rare, it is important to be familiar with this condition to diagnose and treat it correctly.

Safety and Efficacy of Temporal Manual Small Incision Cataract Surgery in India

2011 ◽  
Vol 21 (6) ◽  
pp. 748-753 ◽  
Author(s):  
Swati V. Zawar ◽  
Parikshit Gogate
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Corneal Edema ◽  
Posterior Chamber ◽  
Small Incision Cataract Surgery ◽  
Safety And Efficacy ◽  
Excellent Outcome ◽  
Sutureless Technique ◽  
Small Incision ◽  
Sandwich Method

Purpose. To assess safety and efficacy of temporal manual small incision cataract surgery (SICS) in context to visual outcome, astigmatism, and complications. Methods. This involved sclerocorneal tunnel, capsulotomy and hydrodissection. The incision was made with number 11 disposable surgical blade (costing Indian Rs. 2.50, $0.05). Nucleus extraction was done by phaco-sandwich method with the help of vectis and dialer. Posterior chamber intraocular lens implantation was done according to biometric findings. A record of intraoperative and postoperative complications was made. The final postoperative assessment of astigmatism was done with spectacle correction on the 45th day as per the refraction findings. Results. Two thousand eyes were operated by temporal, manual small incision sutureless technique. Uncorrected visual acuity was ≥6/18 in 1636 (81.7%) patients on the first postoperative day, in 1652 (82.6%) patients at 2 weeks, and in 1732 (88.6%) patients at 6 weeks. Best-corrected visual acuity (BCVA) ≥6/18 was achieved in 1868 (93.4%) patients at 6 weeks, with 46 (2.3%) having BCVA <6/60, 24 (1.2%) of whom had preexisting retinal pathology. At 6 weeks, 1876 (93.8%) eyes had with-the-rule and 134 (6.2%) against-the-rule astigmatism (mean 0.7±1.25 D). Iris prolapse was noted in 3 (0.15%), wound leak in 3 (0.15%), and transient corneal edema in 136 (6.8%) eyes. Average surgery time was 6 minutes. Conclusions. Temporal SICS with number 11 disposable surgical blade and nucleus delivery by phaco-sandwich method gave excellent outcome with minimal astigmatism and low complication rate at economic cost.

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