scholarly journals PNPLA3rs1010023 Predisposes Chronic Hepatitis B to Hepatic Steatosis but Improves Insulin Resistance and Glucose Metabolism

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Qin Pan ◽  
Mei-Mei Chen ◽  
Rui-Nan Zhang ◽  
Yu-Qin Wang ◽  
Rui-Dan Zheng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Glucose Metabolism ◽  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis B ◽  
Normal Population ◽  
Fasting Blood Glucose ◽  
Model Assessment ◽  
Assessment Index

PNPLA3polymorphisms serve as the genetic basis of hepatic steatosis in normal population and lead to dysregulated glucose metabolism. Whether it underlies the hepatic steatosis and glucose homeostasis in chronic hepatitis B patients remains uncertain. Here, we investigated thePNPLA3polymorphisms in biopsy-proven chronic hepatitis B patients with (CHB+HS group,n=52) or without hepatic steatosis (CHB group,n=47) and non-CHB subjects with (HS group,n=37) or without hepatic steatosis (normal group,n=45). When compared to the TT genotype, C-allele atPNPLA3rs1010023 (CC and TC genotypes) conferred higher risk to hepatic steatosis in chronic hepatitis B patients (odds ratio (OR) = 1.768, 95% confidence interval (CI): 1.027–3.105;P=0.045) independent of age, gender, and body mass index. In contrast to their role in hepatic steatosis, CC and TC genotypes ofPNPLA3rs1010023 were correlated to significant improvement of homeostasis model assessment index (HOMA-IR) as compared to TT genotype in the CHB+HS group. Downregulated fasting blood glucose also characterized the CHB+HS patients with C-allele atPNPLA3rs1010023 (CC/TC versus TT: 4.81 ± 0.92 mmol/L versus 5.86 ± 2.11 mmol/L,P=0.02). These findings suggest thatPNPLA3rs1010023 may predispose chronic hepatitis B patients to hepatic steatosis but protects them from glucose dysregulation by attenuating insulin resistance.

scholarly journals Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis

2015 ◽  
Vol 15 (3) ◽  
pp. 714 ◽  
Author(s):  
B Yilmaz ◽  
S Koklu ◽  
H Buyukbayram ◽  
K Yalçin ◽  
U Korkmaz ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis B

scholarly journals Assessment of Hepatic Steatosis in Patients with Chronic Hepatitis B Using Fibroscan and its Relation to Insulin Resistance

2019 ◽  
Vol 9 (1) ◽  
pp. 70-78
Author(s):  
Reham M. Gameaa ◽  
Nehad Hawash ◽  
Rehab Badawi ◽  
Sherief Abd-Elsalam ◽  
Gamal K. Kasem ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis B ◽  
P Value ◽  
Fasting Insulin ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Background & Aim: Simple hepatic steatosis is a benign condition, but it may cause serious liver damage as it may lead to steatohepatitis, fibrosis and cirrhosis. The Controlled Attenuation Parameter (CAP) of fibroscan assesses hepatic steatosis. The aim of this work was to assess hepatic steatosis in patients with chronic hepatitis B infection using FibroScan and to detect its relation to insulin resistance. Methods: Seventy-seven patients with chronic HBV were enrolled in this study. Body mass index, complete lipid profile, fasting insulin, HOMA-IR, pelviabdominal ultrasound and fibroscan were assessed in all patients. Results: According to the presence of significant steatosis, seventy-seven patients enrolled in this study were divided into different groups, such as group I 47 patients (61.04%) with CHB virus infection with non-significant steatosis and group II 30 patients (38.96%) with CHB infection with significant steatosis. There was a statistically significant increase in fasting insulin and HOMA-IR in group II (p-value <0.001). CAP results ranged from 100-396 db/m with no significant difference in liver stiffness measurements in two studied groups (P value= 0.886). There was a significant positive correlation between the degree of hepatic steatosis measured by fibroscan and fasting insulin blood level, HOMA-IR, serum cholesterol and LDL. At cutoff > 222 db/m steatosis measured by fibroscan had a sensitivity of 63.33% and specificity of 82.35% for the detection of insulin resistance. Conclusion: In CHB infected patients, steatosis measurement by fibroscan was a strong predictor of Insulin Resistance (IR) and vice versa.

scholarly journals Significantly Decreased Islet β Cell Function is Closely Associated with Hyperglycemia in Chronic Hepatitis B Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Dafeng Liu ◽  
Lingyun Zhou ◽  
Xinyi Zhang ◽  
Yilan Zeng ◽  
Lang Bai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Hepatitis ◽  
Glucose Metabolism ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cell Function ◽  
Model Assessment ◽  
Β Cell ◽  
Abnormal Glucose Metabolism ◽  
Β Cell Function

Aim. This study is aimed at the characteristics of glucose metabolism and islet β cell function evaluated by the homeostasis model assessment of β cell function (HOMA-β) value and its risk factors in chronic hepatitis B (CHB) patients. Method. This cross-sectional study recruited 110 CHB patients (CHB group) and 110 patients without hepatitis B virus (non-HBV group); the groups were matched according to sex, age, and body mass index under the same glucose metabolism status. The risk factors, characteristics, and differences in glucose metabolism and HOMA-β values between the two groups were analyzed. Results. The abnormal glucose metabolism rate was higher in CHB patients with liver cirrhosis (LC) or hepatitis B envelope antigen (HBeAg) (−) status. In addition, under the same glucose metabolism status, the fasting plasma glucose (FPG) levels and 2-hour postprandial plasma glucose (2h-PG) levels in the CHB group were higher, while the HOMA-β values were significantly lower and the homeostasis model assessment of insulin resistance (HOMA-IR) value was not higher than that in the non-HBV group (all P < 0.0001 ). Further analyses revealed that the main risk factors for abnormal glucose metabolism were HBeAg (−) status and hepatitis B envelope antibody levels. But HBV serological and virological indicators had no effects on the HOMA-β values. Conclusion. Islet β cell function in patients with CHB was compromised, which is closely associated with fasting and postprandial hyperglycemia in chronic hepatitis B patients. Further research should be done to verify the compromised islet β cell function and then to investigate the mechanisms behind the effect of hepatitis B virus infection on islet β cell function in CHB patients.

Sa1053 High Hepatic Iron and Low Serum Betaine Levels Are Associated With Hepatic Steatosis Among Males With Chronic Hepatitis B

2014 ◽  
Vol 146 (5) ◽  
pp. S-948
Author(s):  
Asad Javaid ◽  
Allison B. Goldfine ◽  
Mary-Elizabeth Patti ◽  
Ping Ping Kuang ◽  
Peymei Wu ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis B ◽  
Hepatic Iron ◽  
Low Serum

Hepatic steatosis is uncommon in children with chronic hepatitis B

2009 ◽  
Vol 46 (4) ◽  
pp. 360-362 ◽  
Author(s):  
Antonietta Giannattasio ◽  
Francesco Cirillo ◽  
Vito Terlizzi ◽  
Daniela Liccardo ◽  
Raffaella Vecchione ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Chronic Hepatitis B
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