Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments

Depression, which is characterized by a pervasive and persistent low mood and anhedonia, greatly impacts patients, their families, and society. The associated and recurring sleep disturbances further reduce patient’s quality of life. However, therapeutic sleep deprivation has been regarded as a rapid and robust antidepressant treatment for several decades, which suggests a complicated role of sleep in development of depression. Changes in neural plasticity are observed during physiological sleep, therapeutic sleep deprivation, and depression. This correlation might help us to understand better the mechanism underlying development of depression and the role of sleep. In this review, we first introduce the structure of sleep and the facilitated neural plasticity caused by physiological sleep. Then, we introduce sleep disturbances and changes in plasticity in patients with depression. Finally, the effects and mechanisms of antidepressants and therapeutic sleep deprivation on neural plasticity are discussed.

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Multimodal Physical Therapy Approach on Depression, Anxiety, Stress and Quality of Life in Subject with Home Quarantine for COVID-19 Pandemic Attack- A Case Study From India

10.21203/rs.3.rs-28632/v1 ◽

2020 ◽

Author(s):

Ramesh Patra ◽

Biswajit Kanungo

Keyword(s):

Quality Of Life ◽

Physical Therapy ◽

Sleep Disturbances ◽

Emotional Health ◽

Short Form ◽

Emotional Wellbeing ◽

Depression Anxiety Stress Scale

Abstract Purpose: The main purpose of our study was to evaluate the effectiveness of multidisciplinary physiotherapy approach on depression, anxiety, stress and quality of life during lockdown periods for the COVID-19 pandemic attack. Method: The patient was 56 years female complaining with restlessness and sleep disturbances at night in an outpatient department, Jalandhar Physiotherapy, India. She was a known case of hypertension and grade-2 bilateral knee osteoarthritis. Her level of depression, anxiety and stress was evaluated through DASS-21 (Depression Anxiety Stress Scale) questionnaire. Short Form of health related questionnaire (SF-36) was used for the assessment of quality of life. Emotional liberation breathing technique and multimodal physical therapy approaches were used to treat the patient for 2 weeks of periods 3 sessions per week. Results: After four weeks of follow up the patient was presented with significant improvement in all the parameters depression, anxiety, stress and quality of life (physical functioning, role of limitation-physical health, role of limitation-emotional health, energy, emotional wellbeing, Body pain and general health). These outcomes were reduced the use of analgesics and sedative drugs. Conclusion: Therefore, the outcomes of this case study concluded that multidimensional therapeutic approach is a beneficial approach to manage depression, anxiety, quality of life, and sleep quality.

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Bidirectional relationship between sleep disturbances and stress: the role of coping and quality of life

Annals of Medicine ◽

10.1080/07853890.2018.1562761 ◽

2019 ◽

Vol 51 (sup1) ◽

pp. 191-191

Author(s):

Jorge Cardoso ◽

Telma Almeida ◽

Catarina Ramos ◽

Sara Sousa ◽

José Brito

Keyword(s):

Quality Of Life ◽

Sleep Disturbances ◽

Bidirectional Relationship

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Role of Physiotherapy in Hospice Care of Patients with Advanced Cancer: A Systematic Review

American Journal of Hospice and Palliative Medicine® ◽

10.1177/1049909120951163 ◽

2020 ◽

pp. 104990912095116

Author(s):

Prina Vira ◽

Stephen Rajan Samuel ◽

Sampath Kumar Amaravadi ◽

PU Prakash Saxena ◽

Santosh Rai PV ◽

...

Keyword(s):

Quality Of Life ◽

Advanced Cancer ◽

Sleep Disturbances ◽

Hospice Care ◽

Massage Therapy ◽

Physical Symptoms ◽

Loss Of Function ◽

Compression Bandaging

Objective: To review the role of physiotherapy and its effects in hospice care of patients with advanced cancer. Methods: A comprehensive literature search was performed in PubMed, Scopus, Web of Science, CINAHL and PEDro. The search strategy was devised, articles were screened, and 2 independent reviewers conducted data extraction. Eligible studies were methodologically assessed for quality rating using modified Downs and Black’s checklist. The extracted data was summarized according to site/stage of cancer, details of intervention, outcome measures and the results. Result: The total number of screened articles were 2102, out of which 9 were identified as suitable for the purposes of comprehensive review. The studies included exercise therapy, massage therapy, relaxation therapy, compression bandaging and use of TENS as the various physiotherapy interventions under consideration. Studies were generally of low to moderate quality. A broad range of outcomes were employed including physical symptoms like loss of function, pain, fatigue, edema, sleep disturbances and quality of life. The findings of the studies supported the benefits of the interventions. Conclusion: A structured exercise protocol, massage therapy, TENS and compression bandaging are useful in alleviating the symptoms experienced by patients with advanced cancer in hospice care. The reduced symptom burden has reflected as an improvement in their quality of life. However, there is a further need for high quality studies to strengthen the findings of this review.

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