scholarly journals Increase of Soluble RAGE in Cerebrospinal Fluid following Subarachnoid Haemorrhage

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Bartosz Sokół ◽  
Norbert Wąsik ◽  
Roman Jankowski ◽  
Marcin Hołysz ◽  
Witold Mańko ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Control Group ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Pronounced Difference ◽  
Significance Threshold ◽  
Soluble Rage ◽  
Inflammatory Mechanism ◽  
Glycation End Products ◽  
Csf Levels

Receptors for advanced glycation end-products (RAGE) mediate the inflammatory reaction that follows aneurysmal subarachnoid haemorrhage. Soluble RAGE (sRAGE) may function as a decoy receptor. The significance of this endogenous anti-inflammatory mechanism in subarachnoid haemorrhage (SAH) remains unknown. The present study aims to analyse sRAGE levels in the cerebrospinal fluid (CSF) of SAH patients. sRAGE levels were assayed by ELISA kit in 47 CSF samples collected on post-SAH days 0–3, 5–7, and 10–14 from 27 SAH patients with acute hydrocephalus. CSF levels of sRAGE were compared with a control group and correlated with other monitored parameters. In the control group, the CSF contained only a trace amount of sRAGE. By contrast, the CSF of 20 SAH patients collected on post-SAH days 0–3 was found to contain statistically significant higher levels of sRAGE (mean concentration 3.91 pg/mL, p<0.001). The most pronounced difference in CSF sRAGE levels between good and poor outcome patients was found on days 0–3 post-SAH but did not reach the significance threshold (p=0.234). CSF sRAGE levels did not change significantly during hospitalisation (p=0.868) and correlated poorly with treatment outcome, systemic inflammatory markers, and other monitored parameters. Our study revealed an early and constant increase of sRAGE level in the CSF of SAH patients.

Metabolites from cerebrospinal fluid in aneurysmal subarachnoid haemorrhage correlate with vasospasm and clinical outcome: a pattern-recognition1H NMR study

2005 ◽  
Vol 18 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Victoria G. Dunne ◽  
Shermina Bhattachayya ◽  
Michael Besser ◽  
Caroline Rae ◽  
Julian L. Griffin
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Outcome ◽  
Subarachnoid Haemorrhage ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Nmr Study

Superoxide dismutase activity in cisternal cerebrospinal fluid after aneurysmal subarachnoid haemorrhage

1997 ◽  
Vol 139 (11) ◽  
pp. 1033-1037 ◽  
Author(s):  
P. Gaetani ◽  
C. Cafe ◽  
R. Rodriguez y Baena ◽  
F. Tancioni ◽  
C. Torri ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Superoxide Dismutase ◽  
Subarachnoid Haemorrhage ◽  
Superoxide Dismutase Activity ◽  
Aneurysmal Subarachnoid Haemorrhage

scholarly journals Correction: Soluble Toll-Like Receptors 2 and 4 in Cerebrospinal Fluid of Patients with Acute Hydrocephalus following Aneurysmal Subarachnoid Haemorrhage

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157853
Author(s):  
Bartosz Sokół ◽  
Norbert Wąsik ◽  
Roman Jankowski ◽  
Marcin Hołysz ◽  
Barbara Więckowska ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Toll Like Receptors ◽  
Acute Hydrocephalus

scholarly journals Complications of external cerebrospinal fluid drainage in aneurysmal subarachnoid haemorrhage

2021 ◽  
Author(s):  
Sebastian Arts ◽  
Erik J. van Lindert ◽  
Rene Aquarius ◽  
Ronald H. M. A. Bartels ◽  
Hieronymus D. Boogaarts
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Demographic Data ◽  
Poisson Model ◽  
Medical Complications ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Academic Hospital ◽  
Complication Risk ◽  
External Drain ◽  
The Mean

Abstract Background The need for external cerebrospinal fluid (CSF) drains in aneurysmal subarachnoid haemorrhage (aSAH) patients is common and might lead to additional complications. Objective A relation between the presence of an external CSF drain and complication risk is investigated. Methods A prospective complication registry was analysed retrospectively. We included all adult aSAH patients admitted to our academic hospital between January 2016 and January 2018, treated with an external CSF drain. Demographic data, type of external drain used, the severity of the aSAH and complications, up to 30 days after drain placement, were registered. Complications were divided into (1) complications with a direct relation to the external CSF drain and (2) complications that could not be directly related to the use of an external CSF drain referred to as medical complications Results One hundred and forty drains were implanted in 100 aSAH patients. In total, 112 complications occurred in 59 patients. Thirty-six complications were drain related and 76 were medical complications. The most common complication was infection (n = 34). Drain dislodgement occurred 16 times, followed by meningitis (n = 11) and occlusion (n = 9). A Poisson model showed that the mean number of complications raised by 2.9% for each additional day of drainage (95% CI: 0.6–5.3% p = 0.01). Conclusion Complications are common in patients with aneurysmal subarachnoid haemorrhage of which 32% are drain-related. A correlation is present between drainage period and the number of complications. Therefore, reducing drainage period could be a target for further improvement of care.

scholarly journals Soluble Toll-Like Receptors 2 and 4 in Cerebrospinal Fluid of Patients with Acute Hydrocephalus following Aneurysmal Subarachnoid Haemorrhage

PLoS ONE ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. e0156171 ◽  
Author(s):  
Bartosz Sokół ◽  
Norbert Wąsik ◽  
Roman Jankowski ◽  
Marcin Hołysz ◽  
Barbara Więckowska ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Haemorrhage ◽  
Aneurysmal Subarachnoid Haemorrhage ◽  
Toll Like Receptors ◽  
Acute Hydrocephalus
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