Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study

Background. Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct cardiovascular interactions or by improvements to metabolic function. Both these effects are thought to be at least partly mediated by the GLP-1 receptor (GLP-1R). This case-controlled study investigated whether polymorphisms in theGLP-1Rgene affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population.Methods. Eleven haplotype-tagging single nucleotide polymorphisms (SNPs), distributed across 22 kb of the 39 kbGLP-1Rgene, were selected and genotyped in diabetic patients from a Chinese Han population. Patients were classified based on the severity of coronary artery stenosis. Coronary artery stenosis was ≥50% in 394 patients (coronary artery disease- (CAD-) positive group), and coronary artery stenosis was <50% in 217 patients (control group). Allele and genotype frequencies were compared between the two groups at all 11 SNPs.Results. When considered in recessive inheritance mode, patients with the GG genotype at rs4714210 had a lower CAD risk than patients with other genotypes (OR = 0.442, 95% CI = 0.258–0.757,p=0.002), even when other known CAD risk factors were taken into account (ORa = 0.440, 95%CIa = 0.225–0.863,pa=0.017). In additive inheritance mode, GG genotype carriers at rs4714210 exhibited a lower risk of CAD than AA carriers (ORa = 0.475,CIa = 0.232–0.970,pa=0.041).Conclusion. In type 2 diabetic patients from a Han Chinese population, some variations in theGLP-1Rgene were associated with a lower risk of developing CAD.

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Association of Coronary Artery Stenosis with Carotid Atherosclerosis in Asymptomatic Type 2 Diabetic Patients

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.6049 ◽

2011 ◽

Vol 18 (4) ◽

pp. 337-344 ◽

Cited By ~ 13

Author(s):

Yoko Irie ◽

Kenya Sakamoto ◽

Fumiyo Kubo ◽

Takahiro Okusu ◽

Takashi Katura ◽

...

Keyword(s):

Coronary Artery ◽

Carotid Atherosclerosis ◽

Coronary Artery Stenosis ◽

Artery Stenosis ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

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Evaluation of aortic arch calcification in type 2 diabetic patients

VASA ◽

10.1024/0301-1526.34.2.113 ◽

2005 ◽

Vol 34 (2) ◽

pp. 113-117 ◽

Cited By ~ 4

Author(s):

Papanas ◽

Symeonidis ◽

Maltezos ◽

Giannakis ◽

Mavridis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Arch ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Insulin Dependence ◽

Artery Disease ◽

Type 2 Diabetic ◽

Aortic Arch Calcification

Background: The purpose of this study is to evaluate the severity of aortic arch calcification among type 2 diabetic patients in association with diabetes duration, diabetic complications, coronary artery disease and presence of cardiovascular risk factors. Patients and methods: This study included 207 type 2 diabetic patients (101 men) with a mean age of 61.5 ± 8.1 years and a mean diabetes duration of 13.9 ± 6.4 years. Aortic arch calcification was assessed by means of posteroanterior chest X-rays. Severity of calcification was graded as follows: grade 0 (no visible calcification), grade 1 (small spots of calcification or single thin calcification of the aortic knob), grade 2 (one or more areas of thick calcification), grade 3 (circular calcification of the aortic knob). Results: Severity of calcification was grade 0 in 84 patients (40.58%), grade 1 in 64 patients (30.92%), grade 2 in 43 patients (20.77%) and grade 3 in 16 patients (7.73%). In simple regression analysis severity of aortic arch calcification was associated with age (p = 0.032), duration of diabetes (p = 0.026), insulin dependence (p = 0.042) and presence of coronary artery disease (p = 0.039), hypertension (p = 0.019), dyslipidaemia (p = 0.029), retinopathy (p = 0.012) and microalbuminuria (p = 0.01). In multiple regression analysis severity of aortic arch calcification was associated with age (p = 0.04), duration of diabetes (p = 0.032) and presence of hypertension (p = 0.024), dyslipidaemia (p = 0.031) and coronary artery disease (p = 0.04), while the association with retinopathy, microalbuminuria and insulin dependence was no longer significant. Conclusions: Severity of aortic arch calcification is associated with age, diabetes duration, diabetic complications (retinopathy, microalbuminuria), coronary artery disease, insulin dependence, and presence of hypertension and dyslipidaemia.

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Evaluation of Malondialdehyde (MDA) in type 2 diabetic Patients with Coronary Artery Disease (CAD)

Journal of Biology and Today s World ◽

10.15412/j.jbtw.01030602 ◽

2014 ◽

Vol 3 (6) ◽

Cited By ~ 1

Author(s):

J. Zavar-Reza ◽

H. Shahmoradi ◽

A. Mohammadyari ◽

M. Mohammadbeigi ◽

R. Hosseini ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

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1425-P: White Blood Cell Count Predicts Cardiovascular Prognosis in Type 2 Diabetic Patients with Established Coronary Artery Disease

Diabetes ◽

10.2337/db20-1425-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1425-P

Author(s):

ATSUHIKO KAWABE ◽

YUKI NAKATANI ◽

SHOYA ONO ◽

YASUSHI MIYASHITA ◽

MIHOKO MATSUMURA ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Blood Cell Count ◽

Type 2 Diabetic Patients ◽

Established Coronary Artery Disease ◽

Cardiovascular Prognosis ◽

Artery Disease ◽

Type 2 Diabetic

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Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes

Disease Markers ◽

10.1155/2015/761939 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Ping Song ◽

Jin Xu ◽

Yongfeng Song ◽

Shiliang Jiang ◽

Haitao Yuan ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Logistic Analysis ◽

Artery Disease

Aims. This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients.Methods. 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group.Results. Compared to non-CAD group, CAD group had higher level of plasma MPO (p<0.01). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971–1.547) and 1.488 (1.115–2.228) (p=0.048,p=0.009versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08,p<0.01).Conclusion. Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.

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