Association of Coronary Artery Stenosis with Carotid Atherosclerosis in Asymptomatic Type 2 Diabetic Patients

Background. Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct cardiovascular interactions or by improvements to metabolic function. Both these effects are thought to be at least partly mediated by the GLP-1 receptor (GLP-1R). This case-controlled study investigated whether polymorphisms in theGLP-1Rgene affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population.Methods. Eleven haplotype-tagging single nucleotide polymorphisms (SNPs), distributed across 22 kb of the 39 kbGLP-1Rgene, were selected and genotyped in diabetic patients from a Chinese Han population. Patients were classified based on the severity of coronary artery stenosis. Coronary artery stenosis was ≥50% in 394 patients (coronary artery disease- (CAD-) positive group), and coronary artery stenosis was <50% in 217 patients (control group). Allele and genotype frequencies were compared between the two groups at all 11 SNPs.Results. When considered in recessive inheritance mode, patients with the GG genotype at rs4714210 had a lower CAD risk than patients with other genotypes (OR = 0.442, 95% CI = 0.258–0.757,p=0.002), even when other known CAD risk factors were taken into account (ORa = 0.440, 95%CIa = 0.225–0.863,pa=0.017). In additive inheritance mode, GG genotype carriers at rs4714210 exhibited a lower risk of CAD than AA carriers (ORa = 0.475,CIa = 0.232–0.970,pa=0.041).Conclusion. In type 2 diabetic patients from a Han Chinese population, some variations in theGLP-1Rgene were associated with a lower risk of developing CAD.

Download Full-text

Evaluation of aortic arch calcification in type 2 diabetic patients

VASA ◽

10.1024/0301-1526.34.2.113 ◽

2005 ◽

Vol 34 (2) ◽

pp. 113-117 ◽

Cited By ~ 4

Author(s):

Papanas ◽

Symeonidis ◽

Maltezos ◽

Giannakis ◽

Mavridis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Arch ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Insulin Dependence ◽

Artery Disease ◽

Type 2 Diabetic ◽

Aortic Arch Calcification

Background: The purpose of this study is to evaluate the severity of aortic arch calcification among type 2 diabetic patients in association with diabetes duration, diabetic complications, coronary artery disease and presence of cardiovascular risk factors. Patients and methods: This study included 207 type 2 diabetic patients (101 men) with a mean age of 61.5 ± 8.1 years and a mean diabetes duration of 13.9 ± 6.4 years. Aortic arch calcification was assessed by means of posteroanterior chest X-rays. Severity of calcification was graded as follows: grade 0 (no visible calcification), grade 1 (small spots of calcification or single thin calcification of the aortic knob), grade 2 (one or more areas of thick calcification), grade 3 (circular calcification of the aortic knob). Results: Severity of calcification was grade 0 in 84 patients (40.58%), grade 1 in 64 patients (30.92%), grade 2 in 43 patients (20.77%) and grade 3 in 16 patients (7.73%). In simple regression analysis severity of aortic arch calcification was associated with age (p = 0.032), duration of diabetes (p = 0.026), insulin dependence (p = 0.042) and presence of coronary artery disease (p = 0.039), hypertension (p = 0.019), dyslipidaemia (p = 0.029), retinopathy (p = 0.012) and microalbuminuria (p = 0.01). In multiple regression analysis severity of aortic arch calcification was associated with age (p = 0.04), duration of diabetes (p = 0.032) and presence of hypertension (p = 0.024), dyslipidaemia (p = 0.031) and coronary artery disease (p = 0.04), while the association with retinopathy, microalbuminuria and insulin dependence was no longer significant. Conclusions: Severity of aortic arch calcification is associated with age, diabetes duration, diabetic complications (retinopathy, microalbuminuria), coronary artery disease, insulin dependence, and presence of hypertension and dyslipidaemia.

Download Full-text

Evaluation of Malondialdehyde (MDA) in type 2 diabetic Patients with Coronary Artery Disease (CAD)

Journal of Biology and Today s World ◽

10.15412/j.jbtw.01030602 ◽

2014 ◽

Vol 3 (6) ◽

Cited By ~ 1

Author(s):

J. Zavar-Reza ◽

H. Shahmoradi ◽

A. Mohammadyari ◽

M. Mohammadbeigi ◽

R. Hosseini ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

Download Full-text

1425-P: White Blood Cell Count Predicts Cardiovascular Prognosis in Type 2 Diabetic Patients with Established Coronary Artery Disease

Diabetes ◽

10.2337/db20-1425-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1425-P

Author(s):

ATSUHIKO KAWABE ◽

YUKI NAKATANI ◽

SHOYA ONO ◽

YASUSHI MIYASHITA ◽

MIHOKO MATSUMURA ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Blood Cell Count ◽

Type 2 Diabetic Patients ◽

Established Coronary Artery Disease ◽

Cardiovascular Prognosis ◽

Artery Disease ◽

Type 2 Diabetic

Download Full-text

Predictive Value of Osteoprotegerin for Detecting Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients in Correlation with Extent of Calcification Detected by Multidetector Computed Tomography

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666190211122858 ◽

2019 ◽

Vol 19 (6) ◽

pp. 845-851 ◽

Cited By ~ 1

Author(s):

Sahar Ahmed ◽

Rasha Sobh

Keyword(s):

Coronary Artery ◽

Coronary Artery Calcification ◽

Enzyme Linked Immunosorbent Assay ◽

Diabetic Patients ◽

Coronary Artery Calcification Score ◽

Type 2 Diabetic Patients ◽

Duration Of Diabetes ◽

Calcification Score ◽

Type 2 Diabetic

Background:Osteoprotegerin (OPG) is a tumor necrosis factor receptor super-family member. It specifically acts on bone by increasing bone mineral density and bone volume. Recent studies have evidenced its close relation to the development of atherosclerosis and plaque destabilization. Elevated OPG level has also been associated with the degree of coronary calcification in the general population and it has been considered to be a marker of coronary atherosclerosis.Objective:The aim of this study was to determine the relation between OPG levels and Coronary Artery Calcification score (CACs) in Type 2 diabetic patients in comparison to healthy controls.Methods:Our study included 45 type 2 diabetic patients (mean age 51.7 years; 51.1% male) without evidence of previous CVD and 45 healthy age and sex matched subjects as control. All participants were subjected to full history, full examination and lab investigations. Serum OPG concentration was measured by an enzyme-linked immunosorbent assay (ELISA) and CAC imaging was performed using non contrast Multi detector CT of the heart.Results:Significant CAC (<10 Agatston units) was seen in 23 patients (51.11 %).:OPG was significantly high in diabetic patients in comparison to controls with mean 12.9±5.7 pmol/l in cases, and 8.6±0.5 pmol/l in controls (P value < 0.001).:The Coronary Artery Calcification Score (CACS) was positively correlated with age and duration of diabetes. The OPG was positively correlated with age, fasting blood sugar and duration of diabetes. The CACS showed a significantly positive correlation with OPG.Conclusion:Findings suggested that increasing in serum OPG was consistent with CAC and could be used for the early diagnosis of subclinical atherosclerosis.

Download Full-text