scholarly journals Isolated Superior Mesenteric Vein Tumor Thrombus in a Patient with Gastric Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Barış Özcan ◽  
Metin Çevener ◽  
Ayşegül Kargı ◽  
Mustafa Özdoğan ◽  
Alihan Gürkan
Keyword(s):  
Gastric Cancer ◽  
Portal Vein ◽  
Tumor Thrombus ◽  
Superior Mesenteric Vein ◽  
Locally Advanced ◽  
Hepatic Metastases ◽  
Oral Feeding ◽  
Mesenteric Vein ◽  
Abdominal Disease ◽  
Anastomosis Site

Tumor thrombus in the portal vein can rarely originate from gastric cancer via hematogenous spread, with only few case reports published in the literature. Isolated superior mesenteric vein tumor thrombus in gastric cancer has not been previously reported. A 61-year-old male patient who had undergone distal gastrectomy and gastroenterostomy for gastric ulcer 20 years ago was diagnosed with an obstructive tumor originating from the gastroenterostomy anastomosis site on upper gastrointestinal endoscopy that was performed for complaints of fatigue, oral feeding problems, and anemia. The PET-CT imaging revealed a hypermetabolic mass in the gastroenterostomy region along with hypermetabolic suspected tumor thrombus in the superior mesenteric vein (SMV). A suspected tumor thrombus with contrast enhancement that completely obstructed the SMV was detected on triphasic abdominal computed tomography. Decision for surgery was made due to gastric tumor obstruction. Firstly, lesions suspected with tumor thrombus were extirpated from the SMV and sent to frozen section. Then, it was completely recanalized. A locally advanced tumor originating from the gastroenterostomy anastomosis site that totally obliterated the lumen was observed on surgical exploration. After proving tumor thrombus by frozen, near-total gastrectomy was performed for palliative purposes. Histopathologic examination of the specimen showed gastric invasive adenocarcinoma and tumor thrombi in the SMV (T4N2M1). The patient received adjuvant chemotherapy, and he is at his 22nd-month follow-up with extensive hepatic metastases and intra-abdominal disease. It should be kept in mind that gastric cancer may lead to portal vein tumor thrombus or that it may rarely be associated with an isolated SMV tumor thrombus, both of which are associated with poor prognosis.

scholarly journals Treatment of tumor thrombus in the superior mesenteric vein due to advanced colon cancer with complete surgical resection and chemotherapy: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoshitsugu Yanagida ◽  
Takahiro Amano ◽  
Ryuji Akai ◽  
Akira Toyoshima ◽  
Jotaro Kobayashi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Surgical Resection ◽  
Tumor Thrombus ◽  
Superior Mesenteric Vein ◽  
Tumor Resection ◽  
Term Survival ◽  
Mesenteric Vein ◽  
Advanced Colon Cancer ◽  
Complete Surgical Resection

Abstract Background Tumor thrombus in the superior mesenteric vein secondary to colon cancer is rare. We report a case of tumor thrombus in the superior mesenteric vein and liver metastasis due to advanced colon cancer that was treated with chemotherapy and complete surgical resection. Case presentation A 72-year-old man after transverse colectomy with lymph node dissection for advanced colon cancer was diagnosed with tumor thrombus in the superior mesenteric vein and liver metastasis. He underwent adjuvant chemotherapy and had complete surgical tumor resection involving tumor thrombectomy and hepatectomy. There has been no recurrence at 36 months after surgery. Conclusion Herein, we report a rare case of tumor thrombus in the superior mesenteric vein related to advanced colon cancer. The combination of chemotherapy and complete surgical tumor resection may provide long-term survival.

scholarly journals 5-HT causes splanchnic venodilation

2017 ◽  
Vol 313 (3) ◽  
pp. H676-H686 ◽  
Author(s):  
Bridget M. Seitz ◽  
Hakan S. Orer ◽  
Teresa Krieger-Burke ◽  
Emma S. Darios ◽  
Janice M. Thompson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Inferior Vena Cava ◽  
Portal Vein ◽  
Superior Mesenteric Vein ◽  
Inferior Vena ◽  
Vena Cava ◽  
Receptor Protein ◽  
Mesenteric Vein

Serotonin [5-hydroxytryptamine (5-HT)] causes relaxation of the isolated superior mesenteric vein, a splanchnic blood vessel, through activation of the 5-HT7 receptor. As part of studies designed to identify the mechanism(s) through which chronic (≥24 h) infusion of 5-HT lowers blood pressure, we tested the hypothesis that 5-HT causes in vitro and in vivo splanchnic venodilation that is 5-HT7 receptor dependent. In tissue baths for measurement of isometric contraction, the portal vein and abdominal inferior vena cava relaxed to 5-HT and the 5-HT1/7 receptor agonist 5-carboxamidotryptamine; relaxation was abolished by the 5-HT7 receptor antagonist SB-269970. Western blot analyses showed that the abdominal inferior vena cava and portal vein express 5-HT7 receptor protein. In contrast, the thoracic vena cava, outside the splanchnic circulation, did not relax to serotonergic agonists and exhibited minimal expression of the 5-HT7 receptor. Male Sprague-Dawley rats with chronically implanted radiotelemetry transmitters underwent repeated ultrasound imaging of abdominal vessels. After baseline imaging, minipumps containing vehicle (saline) or 5-HT (25 μg·kg−1·min−1) were implanted. Twenty-four hours later, venous diameters were increased in rats with 5-HT-infusion (percent increase from baseline: superior mesenteric vein, 17.5 ± 1.9; portal vein, 17.7 ± 1.8; and abdominal inferior vena cava, 46.9 ± 8.0) while arterial pressure was decreased (~13 mmHg). Measures returned to baseline after infusion termination. In a separate group of animals, treatment with SB-269970 (3 mg/kg iv) prevented the splanchnic venodilation and fall in blood pressure during 24 h of 5-HT infusion. Thus, 5-HT causes 5-HT7 receptor-dependent splanchnic venous dilation associated with a fall in blood pressure. NEW & NOTEWORTHY This research is noteworthy because it combines and links, through the 5-HT7 receptor, an in vitro observation (venorelaxation) with in vivo events (venodilation and fall in blood pressure). This supports the idea that splanchnic venodilation plays a role in blood pressure regulation.

scholarly journals Peritoneal Patch Used for Vascular Reconstruction of the Superior Mesenteric Vein Invaded by Locally Advanced Pancreatic Tumour

2017 ◽  
Vol 22 (3) ◽  
pp. 132
Author(s):  
Mehmet Tahir Oruc; ◽  
Tuğrul Cakır ◽  
Arif Aslaner ◽  
Erdem Can Yardımcı ◽  
Alkan Sakar
Keyword(s):  
Superior Mesenteric Vein ◽  
Locally Advanced ◽  
Vascular Reconstruction ◽  
Mesenteric Vein ◽  
Pancreatic Tumour

scholarly journals A Case Report of AFP-Producing Gastric Cancer with Portal Vein Tumor Thrombus.

1996 ◽  
Vol 29 (11) ◽  
pp. 2131-2135
Author(s):  
Kenichiro Yamashita ◽  
Hiroshi Shiroto ◽  
Yuji Sato ◽  
Shohei Osawa ◽  
Masao Kondo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Case Report ◽  
Portal Vein ◽  
Tumor Thrombus ◽  
Portal Vein Tumor Thrombus

scholarly journals Splenic vein reconstruction is unnecessary in pancreatoduodenectomy combined with resection of the superior mesenteric vein–portal vein confluence according to short-term outcomes

HPB ◽  
2017 ◽  
Vol 19 (9) ◽  
pp. 785-792 ◽  
Author(s):  
Haruyoshi Tanaka ◽  
Akimasa Nakao ◽  
Kenji Oshima ◽  
Kiyotsugu Iede ◽  
Yukiko Oshima ◽  
...  
Keyword(s):  
Portal Vein ◽  
Superior Mesenteric Vein ◽  
Splenic Vein ◽  
Short Term ◽  
Mesenteric Vein

Portal Vein Thrombosis after Laparoscopic Colectomy: Thrombolytic Therapy via the Superior Mesenteric Vein

2005 ◽  
Vol 71 (10) ◽  
pp. 856-860 ◽  
Author(s):  
George A. Poultsides ◽  
W. Cannon Lewis ◽  
Robert Feld ◽  
David L. Walters ◽  
David A. Cherry ◽  
...  
Keyword(s):  
Portal Vein ◽  
Thrombolytic Therapy ◽  
Venous Thrombosis ◽  
Portal Vein Thrombosis ◽  
Superior Mesenteric Vein ◽  
Right Hemicolectomy ◽  
Published Data ◽  
Mesenteric Vein ◽  
Vein Thrombosis ◽  
Laparoscopic Assisted

Portal vein thrombosis is a rare but well-reported complication after laparoscopic surgery. We present a case of portomesenteric venous thrombosis that occurred 8 days after a laparoscopic-assisted right hemicolectomy. Systemic anticoagulation failed to improve symptoms. The early postoperative state precluded the use of transarterial thrombolytic therapy. Transjugular intra-hepatic catheter-directed infusion of urokinase into the superior mesenteric vein resulted in clearance of thrombus and resolution of symptoms. The published data on laparoscopy-induced splanchnic venous thrombosis and transjugular intrahepatic intramesenteric thrombolysis are discussed.

Contribution of Superior Mesenteric Vein Flow to the Right and Left Lobes of the Liver Using CFD

2009 ◽  
Author(s):  
Stephanie M. George ◽  
Diego R. Martin ◽  
Don P. Giddens
Keyword(s):  
Portal Vein ◽  
Superior Mesenteric Vein ◽  
Splenic Vein ◽  
Normal Subjects ◽  
Diagnostic Techniques ◽  
Mesenteric Vein ◽  
Right Lobe ◽  
Computational Fluid Dynamics Cfd ◽  
The Right ◽  
End Stage

The incidence of cirrhosis, the end stage for many liver diseases, is rising and with it the need for better understanding of the progression of the disease and diagnostic techniques. The authors have noted that liver disease occurs preferentially in the right side of the liver which is the largest lobe. One hypothesis is that this is due to the composition of the blood that supplies the right lobe. The liver is fed by both the hepatic artery and the portal vein with the portal vein contributing about 80% of the blood supply. The portal vein (PV) is supplied by the superior mesenteric vein (SMV), which drains blood from the digestive track, and the splenic vein (SV), which drains blood from the spleen. Since the blood in the SMV is coming from the digestive track, it carries toxins and items absorbed during digestion. Toxins such as alcohol are known to damage the liver. Thus, our hypothesis is that the majority of the SMV flow feeds into the right portal vein and ultimately the right lobe of the liver. This study seeks to assess the validity of our hypothesis in four subjects by creating subject specific models in two normal subjects and two patients and using computational fluid dynamics (CFD) to calculate the SMV contribution to the right portal vein.

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