scholarly journals Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Maria Inês Raposo ◽  
Catarina Meireles ◽  
Mariana Cardoso ◽  
Mariana Ormonde ◽  
Cristina Ramalho ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Rare Condition ◽  
Gynecological Surgery ◽  
Benign Metastasizing Leiomyoma ◽  
Radiological Features ◽  
Genetic Patterns ◽  
Rare Manifestation ◽  
Metastasizing Leiomyoma ◽  
Work Up ◽  
Leiomyoma Of The Uterus

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Here, we report two cases of BML based on similarity of histopathological, immunohistochemical, and genetic patterns between lung nodules and uterine leiomyoma previously resected, evidencing the variability of clinical and radiological features of BML. We highlight the importance of 19q and 22q deletions as highly suggestive of BML. These findings are particularly relevant when there is no uterine sample for review.

scholarly journals Benign Metastasizing Leiomyoma of the Uterus with Pulmonary and Bone Metastases

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Parikshit Padhi ◽  
Margarita Topalovski
Keyword(s):  
Motor Vehicle ◽  
Motor Vehicle Accident ◽  
Rare Condition ◽  
Middle Aged ◽  
Benign Metastasizing Leiomyoma ◽  
Spindle Cell Neoplasm ◽  
Aged Woman ◽  
History Of ◽  
Metastasizing Leiomyoma ◽  
Leiomyoma Of The Uterus

Benign metastasizing leiomyoma (BML) is a rare spindle cell neoplasm seen in middle-aged women who have a history of leiomyoma of the uterus. The most common sites of metastases are the lungs; however, other sites of spread have been documented. These tumors by definition have no malignant features on histology and tend to be estrogen and progesterone positive. We present a middle-aged woman who was incidentally found to have multiple pulmonary nodules and a mass on her sternum after she was involved in a motor vehicle accident. She had a history of uterine leiomyoma and had undergone a hysterectomy ten years prior to the accident. Biopsies were performed of the lung nodules and sternum mass and compared to her hysterectomy specimen, and they were identical, and hence, she was diagnosed with BML. Due to the growing tumor of her sternum, she was started on tamoxifen with stability of her tumors. These tumors, since they are benign, tend to have an indolent course. However, in the instances that treatment is warranted, options include surgery or antiestrogen therapy. We will be discussing the pathogenesis, histological findings, and treatment options of this rare condition. Our case is unique because BML in general do not tend to spread to multiple organs and tend to be limited to one site of disease.

Benign Metastasizing Leiomyoma of the Uterus

1999 ◽  
Vol 123 (10) ◽  
pp. 960-962 ◽  
Author(s):  
Jose M. Esteban ◽  
Warren M. Allen ◽  
Raymond H. Schaerf
Keyword(s):  
Low Grade ◽  
Benign Metastasizing Leiomyoma ◽  
Nuclear Pleomorphism ◽  
Benign Leiomyoma ◽  
Histopathologic Evaluation ◽  
Primary Neoplasm ◽  
Metastasizing Leiomyoma ◽  
Immunohistochemical Studies ◽  
Leiomyoma Of The Uterus ◽  
Rule Out

Abstract Benign uterine leiomyoma metastasizing to the lung is a recognized entity that has been reported infrequently in the medical literature. There is persisting controversy regarding the pathogenesis and biology of these lesions. We report a well-studied and well-characterized case of benign leiomyoma metastasizing to the lung. The patient was a 72-year-old woman with an enlarged uterus that contained several leiomyomas with usual histology. Areas of fibrosis, hyalinization, edema, and focal infarction together with small foci with mildly increased cellularity and minimal nuclear pleomorphism were seen. Careful and repeated mitotic counts ranged from 0 to 2 mitoses per 10 high-power fields. In summary, based on histopathologic criteria, the neoplasm was determined to be a focally cellular benign leiomyoma. Four years later, the patient underwent surgical resection of a single nodule in the lung, which had been detected on routine radiographs. Histopathologic evaluation showed a low-grade leiomyosarcoma with moderate nuclear pleomorphism, necrosis, and brisk mitotic activity. Immunohistochemical studies performed on both neoplasms showed them to be of mesenchymal derivation with smooth muscle differentiation. Both neoplasms expressed estrogen receptors with moderate to strong intensity. The patient received no further treatment and, to date, shows no evidence of recurrent disease. The diagnosis of benign metastasizing leiomyoma can only be made with certainty after careful and extensive sampling of the primary tumor to exclude small foci of sarcoma and of the pulmonary tumor to rule out a primary neoplasm. Although it is biologically peculiar, benign metastasizing leiomyoma should continue to be recognized as a distinct entity because current morphologic criteria do not allow primary myometrial tumors to be reclassified as leiomyomas of uncertain malignant potential even if they have metastasized to the lung.

scholarly journals Benign Metastasizing Leiomyoma: A Rare Type of Lung Metastases—Two Case Reports and Review of the Literature

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Rokana Taftaf ◽  
Sandra Starnes ◽  
Jiang Wang ◽  
Ralph Shipley ◽  
Tariq Namad ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Progesterone Receptors ◽  
Pulmonary Nodules ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Benign Metastasizing Leiomyoma ◽  
Ct Guided ◽  
First Case ◽  
History Of ◽  
Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare disease that usually occurs in women of reproductive age. They typically have history of uterine leiomyoma treated with hysterectomy. BML can metastasize to distant organs, with the lung being the most common organ. We report two patients who presented with benign metastasizing leiomyoma to the lung. Our first case was a fifty-two-year-old female who presented with multiple lung masses, with a past medical history of uterine leiomyoma who underwent hysterectomy 17 years ago. A CT-guided biopsy showed benign appearing spindle cells and pathology confirmed her diagnosis with additional positive estrogen/progesterone receptor stains. Our second case was a fifty-six-year-old female who presented with multiple cavitary pulmonary nodules. She subsequently underwent a video-assisted thoracoscopic surgery (VATS) with wedge resection of one of the nodules. Pathology confirmed the diagnosis based on morphology and immunohistochemical staining strongly positive for estrogen/progesterone receptors. Benign metastasizing leiomyoma is a rare condition which may affect women of reproductive age. This should be considered in the differential in patients who present with multiple pulmonary nodules, especially with a history of uterine leiomyoma. Additional stains, such as estrogen/progesterone receptors, may need to be done to confirm the diagnosis.

scholarly journals Pulmonary benign metastasizing leiomyoma from uterine leiomyoma

2013 ◽  
Vol 11 (1) ◽  
pp. 163 ◽  
Author(s):  
Sufeng Chen ◽  
Yawei Zhang ◽  
Jie Zhang ◽  
Hong Hu ◽  
Yufan Cheng ◽  
...  
Keyword(s):  
Uterine Leiomyoma ◽  
Benign Metastasizing Leiomyoma ◽  
Metastasizing Leiomyoma
Sign in / Sign up

Export Citation Format

Share Document