Raloxifene Has No Efficacy in Reducing the High Bone Turnover and the Risk of Spontaneous Vertebral Fractures after Denosumab Discontinuation
Keyword(s):
At denosumab discontinuation, an antiresorptive agent is prescribed to reduce the high bone turnover, the rapid bone loss, and the risk of spontaneous vertebral fractures. We report the case of a woman treated with aromatase inhibitors and denosumab for 5 years. Raloxifene was then prescribed to prevent the rebound effect. Raloxifene was ineffective to reduce the high bone turnover and to avoid spontaneous clinical vertebral fractures. We believe that among the antiresorptive treatments, the most powerful bisphosphonates should be favored, and their administration adapted according to the serial follow-up of bone markers.
2001 ◽
Vol 72
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pp. 83-88
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1996 ◽
Vol 26
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pp. 549-555
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2007 ◽
Vol 67
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pp. 1249-1255
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2018 ◽
Vol Volume 13
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pp. 1929-1934
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1990 ◽
Vol 46
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pp. 314-317
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2002 ◽
Vol 177
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pp. 139-141
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2006 ◽
Vol 21
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pp. 1924-1934
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