Urachal Mucinous Cystic Tumor of Low Malignant Potential with Concurrent Sigmoid Colon Adenocarcinoma

Urachal mucinous tumors are rare neoplasms with behaviour that can range from relatively benign to malignancy that can spread distantly or throughout the peritoneum as pseudomyxoma peritonei or peritoneal carcinomatosis. Here we describe a unique case of urachal mucinous cystic tumor of low malignant potential confined to an intact cyst at the dome of the urinary bladder, without rupture or peritoneal spread. The urachal mucinous tumor was an incidental finding on a staging CT scan performed for sigmoid colon adenocarcinoma. We believe that this case illustrates a potential diagnostic pitfall which could have prognostic and therapeutic implications. Due to the intestinal phenotype of these neoplasms, a urachal tumor of low malignant potential could be mistaken for metastatic spread from a colonic adenocarcinoma in the rare situation such as this case, where the two neoplasms occur concurrently.

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Urachal mucinous cystic tumor of low malignant potential in a polymorbid female: a case report and review of the literature

International Cancer Conference Journal ◽

10.1007/s13691-021-00530-x ◽

2022 ◽

Author(s):

Benjamin Schmeusser ◽

Joseph Wiedemer ◽

Dana Obery ◽

Kaila Buckley ◽

Michael Yu

Keyword(s):

Surgical Excision ◽

Academic Community ◽

Malignant Potential ◽

Cystic Tumor ◽

Surgical Removal ◽

Mucinous Cystic Tumor ◽

Urinary Tract Symptoms ◽

Low Malignant Potential ◽

Clinical Considerations ◽

Cure Rates

AbstractNeoplasms of the urachus are exceedingly rare, representing 0.17% of all bladder cancers. The mucinous cystic tumor of low malignant potential (MCTLMP) subtype is particularly rare with just 25 previous cases reported in the literature. Although rare, MCTLMPs are important to identify due to potential devastating complications and good cure rates with surgical removal. We present a 43 year old female with a nuanced constellation of comorbidities and confirmed MCTLMP following a workup for abdominal pain and irritative lower urinary tract symptoms. Notably, this tumor did not change in size over a 3-year course of serial imaging prior to surgical excision. This urachal MCTLMP represents roughly the 26th and one of the smallest of its subtype reported in the literature. This case illustrates the diagnosis and management of this rare urachal MCTLMP. Individual patient medical history, clinical considerations, and neoplasm characteristics are examined. Although rare, the potential for increased malignancy and potential complications necessitates surgical management and further investigation by the academic community.

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Primary retroperitoneal mucinous cystic tumor of low malignant potential-A case report-

The Journal of the Japanese Society of Clinical Cytology ◽

10.5795/jjscc.47.372 ◽

2008 ◽

Vol 47 (5) ◽

pp. 372-376

Author(s):

Noriko ABE ◽

Syouichiro SANADA ◽

Tomoko HARADA ◽

Tatsunari SATAKE ◽

Nobuo NAKASHIMA ◽

...

Keyword(s):

Case Report ◽

Malignant Potential ◽

Cystic Tumor ◽

Mucinous Cystic Tumor ◽

Low Malignant Potential ◽

Primary Retroperitoneal

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Mucinous Cystadenoma of the Urachus and Review of Current Classification of Urachal Mucinous Cystic Neoplasms

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2017-0319-rs ◽

2018 ◽

Vol 143 (2) ◽

pp. 258-263

Author(s):

Diping Wang ◽

Norbert Sule

Keyword(s):

Mucinous Cystadenoma ◽

Malignant Potential ◽

World Health ◽

Mucinous Cystadenocarcinoma ◽

Cystic Tumor ◽

Mucinous Cystic Tumor ◽

Cystic Neoplasms ◽

Mucinous Cystic Neoplasms ◽

Low Malignant Potential ◽

Health Organization

Urachal neoplasms are uncommon and represent a minor portion of bladder tumors. According to the recently updated World Health Organization classification (2016), these tumors are classified as adenomas, adenocarcinomas, nonglandular neoplasms, and mixed carcinomas. The mucinous cystic neoplasms represent a small percentage of urachal tumors with morphologic spectrum ranging from benign mucinous cystadenoma to borderline mucinous cystic tumor of low malignant potential and to malignant mucinous cystadenocarcinoma. Benign urachal mucinous cystic adenomas are exceedingly rare, and only a few cases have been reported in the literature to date. The goal of this review is to summarize the clinical features, histopathologic characteristics, treatment, and prognosis of urachal mucinous cystadenoma in light of differentiating them from mucinous cystic tumor of low malignant potential and mucinous cystadenocarcinoma.

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Incidental Finding of a Rare Urachal Pathology: Urachal Mucinous Cystic Tumour of Low Malignant Potential

Case Reports in Urology ◽

10.1155/2016/5764625 ◽

2016 ◽

Vol 2016 ◽

pp. 1-2 ◽

Cited By ~ 1

Author(s):

Luke L. Wang ◽

Heath Liddell ◽

Sharman Tan Tanny ◽

Briony Norris ◽

Sree Appu ◽

...

Keyword(s):

Pseudomyxoma Peritonei ◽

Incidental Finding ◽

Surgical Excision ◽

Malignant Potential ◽

Pathological Findings ◽

Cystic Tumour ◽

Complete Surgical Excision ◽

Low Malignant Potential

Urachal mucinous cystic tumours are rare pathological findings with only 23 previously reported cases in the literature. We present the case of a 54-year-old man with an incidentally found urachal mucinous cystic tumour laparoscopically excised. With its known potential to cause pseudomyxoma peritonei, complete surgical excision is important. Long-term cystoscopic and radiological surveillance is also required.

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Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽

10.1024/1023-9332.8.1.7 ◽

2002 ◽

Vol 8 (1) ◽

pp. 7-10 ◽

Cited By ~ 6

Author(s):

Altinli ◽

Pekmezci ◽

Balkan ◽

Somay ◽

M. Akif Buyukbese ◽

...

Keyword(s):

Lymph Nodes ◽

Hodgkin Lymphoma ◽

Sigmoid Colon ◽

Castleman’S Disease ◽

Malignant Potential ◽

Colon Tumor ◽

Rare Entity ◽

Castleman's Disease ◽

Mediastinal Lymph Nodes ◽

Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

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Current controversies in the biology and management of ovarian tumors of low malignant potential

The Women s Oncology Review ◽

10.3109/14733400600604448 ◽

2007 ◽

Vol 6 (1-2) ◽

pp. 15-25

Author(s):

William E. Winter ◽

Douglas N. Brown ◽

Charles A. Leath

Keyword(s):

Malignant Potential ◽

Ovarian Tumors ◽

Low Malignant Potential

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Filiform polyposis with sigmoid colon adenocarcinoma: a case report

Surgical Case Reports ◽

10.1186/s40792-019-0747-x ◽

2019 ◽

Vol 5 (1) ◽

Author(s):

Takayuki Okuno ◽

Takamitsu Kanazawa ◽

Hirohisa Kishi ◽

Hiroyuki Anzai ◽

Koji Yasuda ◽

...

Keyword(s):

Sigmoid Colon ◽

Colon Adenocarcinoma ◽

Resected Specimen ◽

Normal Colonic Mucosa ◽

Histological Findings ◽

P53 Expression ◽

History Of ◽

Reparative Process ◽

Inflammatory Polyposis ◽

Filiform Polyposis

Abstract Background Filiform polyposis is a rare form of inflammatory polyposis, which is occasionally formed in the colon of patients with history of inflammatory bowel disease (IBD). It is characterized by presence of several to hundreds of slender, worm-like polyps in the colon lined by histologically normal colonic mucosa and often coalesce, resulting in a tumor-like mass. Filiform polyposis is most frequently associated with a post-inflammatory reparative process in patients with IBD history, and only cases of filiform polyposis occurring in patients without IBD history have been reported. Filiform polyposis has been considered as a benign inflammatory polyposis without any risk of dysplasia, while the possibility of carcinogenesis of inflammatory polyps is not fully excluded. To date, only three cases of filiform polyposis coexisting with dysplasia have been reported. Case presentation A 59-year-old male patient with no past medical history of IBD underwent laparoscopic sigmoidectomy for obstructive filiform polyposis, which was associated with sigmoid colon adenocarcinoma. Based on the histological findings of the resected specimen, invasive sigmoid colon adenocarcinoma was surrounded by filiform polyposis, and adenocarcinoma also scattered uniformly on the surface of filiform polyposis. In immunohistochemistry, abnormal p53 expression was observed in adenocarcinoma, while it was not shown in mucosa on filiform polyposis. Conclusions This is the fourth case of filiform polyposis that is closely associated with colon dysplasia or adenocarcinoma based on histological findings. However, immunohistochemical findings did not support the theory that inflammation initiates adenocarcinoma in filiform polyposis like IBD. Hence, further immunohistochemical and genetic analyses are needed to clarify the association between filiform polyposis and carcinogenesis.

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