scholarly journals Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Taha O. Mahwi ◽  
Darya S. Abdulateef
Keyword(s):  
Sunshine Duration ◽  
Winter Season ◽  
Extreme Temperature ◽  
Temperate Climate ◽  
Human Pituitary ◽  
Positive Correlation ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Different Seasons ◽  
Thyroid Axis

Background. Various changes in thyroid hormones (TH) and thyroid-stimulating hormone (TSH) level were observed in different seasons among euthyroid and hypothyroid subjects living in areas with an extreme temperature difference between summer and winter.Objectives. This study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH.Method.In a prospective study on 152 healthy (euthyroid) volunteers and 25 SCH subjects, the serum hormone levels (TSH, FT4, and FT3) were measured in both the summer and winter seasons and correlated with all the climate components using Pearson’s correlation coefficient. The effect of duration of outdoor exposure on hormone levels was compared using a paired samplet-test (P<0.05).Results. Small but statistically significant increased FT3 level and decreased FT4 level were observed during the winter season in euthyroid and SCH subjects, respectively. There was a significant negative correlation between FT3 and FT3/FT4 ratio with temperature and sunshine duration and a positive correlation with humidity and atmospheric pressure. A positive correlation was found between FT4 and sunshine duration.Conclusion. The climate components contributed to the slight variance in hormone levels in different seasons, and the effect was mostly on peripheral conversion of FT4 to FT3 rather than the pituitary-thyroid axis leading to slightly higher FT3 in winter. Seasonal variation does not affect the diagnosis of SCH cases.

Plasma neurotensin levels in humans: relation to hormone levels in diseases involving the hypothalamo-pituitary-thyroid axis

1995 ◽  
Vol 133 (5) ◽  
pp. 534-538 ◽  
Author(s):  
Rose-Marie Schimpff ◽  
Micheline Gourmelen ◽  
Valérie Scarcériaux ◽  
Anne-Marie Lhiaubet ◽  
William Rostène
Keyword(s):  
Healthy Adults ◽  
Thyroid Status ◽  
Central Hypothyroidism ◽  
Mean Values ◽  
Hormone Levels ◽  
Percentage Decrease ◽  
Pituitary Thyroid Axis ◽  
Endocrine Status ◽  
Thyroid Axis ◽  
Adult Volunteers

Schimpff R-M, Gourmelen M, Scarcériaux V, Lhiaubet A-M, Rostène W. Plasma neurotensin levels in humans: relation to hormone levels in diseases involving the hypothalamo-pituitary-thyroid axis. Eur J Endocrinol 1995;133:534–8. ISSN 0804–4643 This study was aimed to investigate, in humans, the possible relationship between plasma neurotensin (NT) levels and the activity of the hypothalamo-pituitary-thyroid axis. Neurotensin was measured by radioimmunoassay in 14 healthy adult volunteers and in 41 patients among whom 10 were considered as controls and 31 had thyroid dysfunction according to free thyroxine and thyrotropin plasma values. Basal NT levels were not significantly different in healthy adults and in control patients: 9.7 ± 1.1 fmol/ml (mean±sem) vs 13.3 ± 2.9fmol/ml, respectively. In patients with central hypothyroidism the NT level was significantly lower (5.7 ± 1.2 vs healthy volunteers and controls; p < 0.05) and in patients with peripheral hypothyroidism and hyperthyroidism the NT level was significantly higher (35.9 ± 12.8 and 29.9 ± 9.5 fmol/ml, respectively, vs healthy adults (p < 0.01) and vs controls (p < 0.05)). After thyrotropin-releasing hormone (TRH) injection (250 μg iv) in nine subjects (two control patients, five patients with hypothyroidism and two patients with hyperthyroidism), NT levels decreased independently of the endocrine status from mean values of 13.4 ± 8.4 at basal level to 7.3 ± 0.8 fmol/ml 30 min after injection (p < 0.01 on paired percentage decrease values). These data suggest that plasma NT levels in humans depend upon the pituitary-thyroid status and indicate that TRH could exert a negative regulation on circulating NT levels. R-M Schimpff, INSERM U 339. Hôpital St Antoine, 184 rue du Faubourg, St Antoine, Paris 75012, France

The effect of benziodarone on the thyroid hormone levels and the pituitary-thyroid axis

1986 ◽  
Vol 9 (4) ◽  
pp. 337-339 ◽  
Author(s):  
B. Xanthopoulos ◽  
D. A. Koutras ◽  
M. A. Boukis ◽  
G. D. Piperingos ◽  
J. Kitsopanides ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Thyroid Hormone Levels

scholarly journals Analysis of the correlation between lipotoxicity and pituitary-thyroid axis hormone levels in men and male rats

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39332-39344 ◽  
Author(s):  
Jianmei Yang ◽  
Xiaoming Zhou ◽  
Xu Zhang ◽  
Jianting Hu ◽  
Ling Gao ◽  
...  
Keyword(s):  
Male Rats ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

Effects of substances on plants' active compounds on changes in the hormone levels of the pituitary–Thyroid axis in hyperthyroidism and hypothyroidism

2018 ◽  
Vol 12 (23) ◽  
pp. 1 ◽  
Author(s):  
Mahmoud Rafieian-Kopaei ◽  
Elahe Aleebrahim-Dehkordy ◽  
Sadra Ansaripour ◽  
Shirin Saberianpour
Keyword(s):  
Active Compounds ◽  
Hormone Levels ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

scholarly journals Differential Effects of Central Leptin, Insulin, or Glucose Administration during Fasting on the Hypothalamic-Pituitary-Thyroid Axis and Feeding-Related Neurons in the Arcuate Nucleus

Endocrinology ◽  
2006 ◽  
Vol 147 (1) ◽  
pp. 520-529 ◽  
Author(s):  
Csaba Fekete ◽  
Praful S. Singru ◽  
Edith Sanchez ◽  
Sumit Sarkar ◽  
Marcelo A. Christoffolete ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Arcuate Nucleus ◽  
Mrna Levels ◽  
Central Administration ◽  
Hormone Levels ◽  
Intracerebroventricular Infusion ◽  
Essential Components ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Thyroid Hormone Levels

The reductions in circulating levels of leptin, insulin, and glucose with fasting serve as important homeostasis signals to neurons of the hypothalamic arcuate nucleus that synthesize neuropeptide Y (NPY)/agouti-related protein (AGRP) and α-MSH/cocaine and amphetamine-regulated transcript. Because the central administration of leptin is capable of preventing the inhibitory effects of fasting on TRH mRNA in hypophysiotropic neurons primarily through effects on the arcuate nucleus, we determined whether the continuous administration of 30 mU/d insulin or 648 μg/d glucose into the cerebrospinal fluid by osmotic minipump might also have similar effects on the hypothalamic-pituitary-thyroid axis. As anticipated, the intracerebroventricular infusion of leptin reduced fasting-induced elevations in NPY and AGRP mRNA and increased proopiomelanocortin and cocaine and amphetamine-regulated transcript mRNA in the arcuate nucleus. In addition, leptin prevented fasting-induced reduction in pro-TRH mRNA levels in the paraventricular nucleus and in circulating thyroid hormone levels. In contrast, whereas insulin increased proopiomelanocortin mRNA and both insulin and glucose reduced NPY mRNA in arcuate nucleus neurons, neither prevented the fasting-induced suppression in hypophysiotropic TRH mRNA or circulating thyroid hormone levels. We conclude that insulin and glucose only partially replicate the central effects of leptin and may not be essential components of the hypothalamic-pituitary-thyroid regulatory system during fasting.

Effect of N3im-Methyl-Thyrotropin Releasing Hormone on the Human Pituitary-Thyroid Axis

1976 ◽  
Vol 43 (4) ◽  
pp. 741-748 ◽  
Author(s):  
JAMES R. SOWERS ◽  
JEROME M. HERSHMAN ◽  
A. EUGENE PEKARY ◽  
M. G. NAIR ◽  
CHARLES M. BAUGH
Keyword(s):  
Thyrotropin Releasing Hormone ◽  
Human Pituitary ◽  
Releasing Hormone ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

N-acetyltransferase activity in the Harderian glands of the Syrian hamster, Mesocricetus auratus, is regulated by androgens and by hormones of the pituitary-thyroid axis

1990 ◽  
Vol 127 (1) ◽  
pp. 59-67 ◽  
Author(s):  
G. R. Buzzell ◽  
A. Menendez-Pelaez ◽  
R. A. Hoffman ◽  
M. K. Vaughan ◽  
R. J. Reiter
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Harderian Gland ◽  
Hormone Levels ◽  
Harderian Glands ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Tsh Levels

ABSTRACT This study tested the hypothesis that activity of the enzyme N-acetyltransferase (NAT) in the Harderian gland of the Syrian hamster is regulated both by androgens and by hormones of the pituitary-thyroid axis. To test the effects of castration and hypothyroidism, intact or castrated male hamsters were given either tap water or methimazole in their drinking water for 3 weeks. Methimazole suppresses iodination of thyroglobulin, thereby decreasing circulating levels of thyroid hormones and increasing TSH levels. Hypothyroidism or castration caused elevated or depressed Harderian gland NAT activities respectively, compared with euthyroid controls. When castration and hypothyroidism were combined, the animals exhibited high NAT activity compared with castrated euthyroid males. To test the effects of castration and hyperthyroidism, male hamsters were given daily injections of thyroxine (T4) or diluent and were either castrated or left intact for 4 weeks. Intact animals given T4 had depressed Harderian NAT activity; serum thyroid hormone levels were elevated and TSH levels were depressed compared with those of intact controls. Castrated animals had depressed NAT activity below that of intact controls; serum thyroid hormone levels were normal but TSH levels were depressed. Castrated animals given T4 injections had NAT activity similar to that of euthyroid castrated hamsters; thyroid hormone levels were elevated but TSH levels were similar to those seen in euthyroid castrated hamsters. In another experiment, both T4 and tri-iodothyronine (T3) were equally effective in decreasing NAT activity in intact males. To determine the effects of the removal of pituitary influences, male hamsters were hypophysectomized. NAT activity in the Harderian glands of these animals was reduced compared with intact controls. Injection of T4 in hypophysectomized male hamsters did not alter NAT activity from that of hypophysectomized hamsters. Female hamsters given methimazole for 3 weeks had elevated Harderian NAT activity compared with controls. Injection of T4 or T3 for 4 weeks led to significantly reduced Harderian gland NAT activity compared with untreated controls. This response to thyroid hormones was the same, whether T4 or T3 was used. These results can be explained by androgens stimulating Harderian NAT activity, as has been suggested by previous published reports, and by NAT activity being inhibited by thyroid hormones or stimulated by TSH. Journal of Endocrinology (1990) 127, 59–67

Sign in / Sign up

Export Citation Format

Share Document