scholarly journals Changes in the Management of Patients with Crohn’s Disease Based on Magnetic Resonance Enterography Patterns

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Evelyn Sayuri S. Chinem ◽  
Barbara C. Esberard ◽  
Andre da L. Moreira ◽  
Tatiana G. Barbassa ◽  
Guilherme M. da Cunha ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography ◽  
Medical Decisions ◽  
Cross Sectional ◽  
Therapeutic Decisions ◽  
The Impact

Background and Aims. Magnetic resonance enterography (MRE) has become an important modality of radiological imaging in the evaluation of Crohn’s disease (CD). The aim of this study was to investigate the impact of MRE in the assessment of disease activity and abdominal complications and in the making of therapeutic decisions for patients with CD. Methods. In a cross-sectional retrospective study, we selected 74 patients with CD who underwent MRE and ileocolonoscopy with an interval between the two exams of up to 30 days between January 2011 and December 2017. We assessed the parameters of the images obtained by MRE and investigated the agreement with the level of disease activity and complications determined by a clinical evaluation, inflammatory biomarkers, and endoscopy, as well as the resulting changes in medical and surgical management. Results. Changes in medical management were detected in 41.9% of patients. Significant changes in medical decisions were observed in individuals with a purely penetrating (P=.012) or a mixed (P=.024) MRE pattern. Patients with normal MRE patterns had a correlation with unchanged medical decisions (P=.001). There were statistically significant agreements between the absence of inflammatory criteria on MRE and remission according to the Harvey and Bradshaw index (HBI) (P=.037), the presence of inflammatory criteria on MRE and positive results for calprotectin (P=.005), and penetrating criteria on MRE and the scoring endoscopic system for Crohn’s disease (SES-CD), indicating active disease (P=.048). Finally, there was significant agreement between the presence of fibrostenotic criteria and a long disease duration (P=.027). Conclusion. MRE discloses disease activity and complications not apparent with other modalities and results in changes in therapeutic decisions. In addition to being used for diagnosis, MRE should be routinely used in the follow-up of CD patients.

Magnetic resonance enterography in Crohn’s disease: new simple proposal to assess disease activity

2016 ◽  
Vol 40 (3) ◽  
pp. 492-497 ◽  
Author(s):  
Elsa Iannicelli ◽  
Isabella Martini ◽  
Claudia Fantini ◽  
Claudio Papi ◽  
Paola Gigante ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography

T1279 Magnetic Resonance Enterography in the Assessment of the Disease Activity in Crohn's Disease – A Retrospective Study

2010 ◽  
Vol 138 (5) ◽  
pp. S-527
Author(s):  
Carmen S. Horjus ◽  
Rutger Bruijnen ◽  
Dirk J. De Jong ◽  
Martijn G. van Oijen ◽  
Marcel J. Groenen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Retrospective Study ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography

scholarly journals Magnetic resonance enterography, colonoscopy, and fecal calprotectin correlate in colonic Crohn’s disease

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Alexander S. Somwaru ◽  
Vikesh Khanijow ◽  
Venkat S. Katabathina
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Clinical Results ◽  
Fecal Calprotectin ◽  
Magnetic Resonance Enterography ◽  
Crohn’S Disease Activity

Abstract Background Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of these tests, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We prospectively investigated if there is correlation between these three tests, which may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification. Methods One hundred fifty-six patients with colonic CD were prospectively examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS). Results One hundred twelve patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between. MaRIA and CDEIS (r = 0.63, P = 0.01). Conclusions FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.

Tu1213 Reproducibility of Magnetic Resonance Enterography Assessment of Disease Activity in Crohn's Disease Using Central Readers

2015 ◽  
Vol 148 (4) ◽  
pp. S-824 ◽  
Author(s):  
Ingrid Ordás ◽  
Jordi Rimola ◽  
Guangyong Zou ◽  
Cynthia Santillan ◽  
Karin Horsthuis ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography ◽  
Assessment Of Disease Activity

scholarly journals Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in colonic Crohn’s Disease

2019 ◽  
Author(s):  
Alexander Stephen Somwaru ◽  
Vikesh Khanijow ◽  
Venkat Katabathina
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Activity Index ◽  
Disease Activity Index ◽  
Clinical Results ◽  
Fecal Calprotectin ◽  
Magnetic Resonance Enterography ◽  
Crohn’S Disease Activity

Abstract Background Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of two of these tests or surgical specimens, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We investigated if the correlation between these three tests may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification. Methods 156 patients with colonic CD were examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS). Results 112 patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between MaRIA and CDEIS (r = 0.63, P = 0.01). Conclusions FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.

scholarly journals Reliability of Measuring Ileo-Colonic Disease Activity in Crohn’s Disease by Magnetic Resonance Enterography

2018 ◽  
Vol 24 (2) ◽  
pp. 440-449 ◽  
Author(s):  
Vipul Jairath ◽  
Ingrid Ordas ◽  
Guangyong Zou ◽  
Julian Panes ◽  
Jaap Stoker ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Crohn's Disease ◽  
Disease Activity ◽  
Magnetic Resonance Enterography ◽  
Colonic Disease
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