scholarly journals Differences in Leukocyte Telomere Length between Coronary Heart Disease and Normal Population: A Multipopulation Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaofeng Xu ◽  
Haochang Hu ◽  
Ying Lin ◽  
Fangzhong Huang ◽  
Huihui Ji ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Design Method ◽  
Normal Population ◽  
Meta Analysis ◽  
Cardiovascular Death ◽  
Leukocyte Telomere Length ◽  
Asian Patients ◽  
Common Causes

Coronary heart disease (CHD) is one of the most common causes of death in the world. Numerous studies have shown that as the degree of atherosclerotic disease increases, leukocyte telomere length gradually decreases. Short telomeres increase the risk of all-cause death and cardiovascular death. However, the reported results are not consistent, since the experimental design method, the measurement method, and the disease outcome are different. Therefore, we searched five major literature databases (Pubmed, Web of science, Embase, CNKI, and Wangfang) and finally included 18 eligible articles (including 5,150 patients with CHD and 9341 controls). We found that telomere length in patients with CHD was significantly shorter than that in controls, and the telomere length was inversely correlated with the severity of CHD. Subgroup analysis showed that telomere shortening was the most significant in Asian patients with CHD, in CHD patients with an average age <65 years, and in men with CHD. The mechanism of shortening the telomere length leading to the occurrence and development of CHD is worthy of further study.

Abstract P213: Association Between Depression and Leukocyte Telomere Length in Patients With Stable Coronary Heart Disease: Data From the Heart and Soul Study

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Petra Hoen ◽  
Peter de Jonge ◽  
Beeya Na ◽  
Ramin Farzaneh-Far ◽  
Elissa Epel ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Major Depressive Disorder ◽  
Heart Disease ◽  
Major Depression ◽  
Depressive Disorder ◽  
Telomere Length ◽  
Quantitative Polymerase Chain Reaction ◽  
Leukocyte Telomere Length ◽  
Major Depressive ◽  
Stable Coronary Heart Disease

Background Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered an emerging marker of biological age. Whether short telomere length is associated with depression in patients with CHD has not been evaluated. Methods In a cross-sectional study of 952 outpatients with stable CHD, we ascertained the presence of major depressive disorder using the Computerized Diagnostic Interview Schedule. Relative mean telomere length was measured from leukocyte DNA using a quantitative polymerase chain reaction assay. We examined the association between depression and leukocyte telomere length using linear and logistic regression models. Results Of the 952 participants, 206 (22%) had current (past month) depression. Patients with depression had lower mean ± SE telomere length than those without depression ( Table ). Likewise, patients with MDD had a 70% greater odds of having telomere length in the lowest vs. highest quartile (adjusted OR 1.70. 95% CI, 1.05-2.76; p=0.03). Conclusion Major depressive disorder is associated with reduced leukocyte telomere length in patients with stable CHD. The potential mechanisms underlying this association deserve further study. Mean +/- SE telomere length by presence of major depressive disorder Adjusted for Current major depression N=206 No current major depression N=746 P value age, sex 0.86±0.02 0.90±0.1 .02 age, sex, diabetes, BMI, smoking 0.86±0.02 0.89±0.01 .04 age, sex, diabetes, BMI, smoking, LVEF, statin use 0.85±0.02 0.89±0.01 .03

scholarly journals Association of TERC and OBFC1 Haplotypes with Mean Leukocyte Telomere Length and Risk for Coronary Heart Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e83122 ◽  
Author(s):  
Cécilia G. Maubaret ◽  
Klelia D. Salpea ◽  
Casey E. Romanoski ◽  
Lasse Folkersen ◽  
Jackie A. Cooper ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Leukocyte Telomere Length

scholarly journals Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0160748 ◽  
Author(s):  
Sarah E. Goglin ◽  
Ramin Farzaneh-Far ◽  
Elissa S. Epel ◽  
Jue Lin ◽  
Elizabeth H. Blackburn ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Stable Coronary Heart Disease

scholarly journals Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease

2011 ◽  
Vol 73 (7) ◽  
pp. 541-547 ◽  
Author(s):  
Petra W. Hoen ◽  
Peter de Jonge ◽  
Bee Ya Na ◽  
Ramin Farzaneh-Far ◽  
Elissa Epel ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Leukocyte Telomere Length

Lack of causal relationship between leukocyte telomere length and coronary heart disease

2014 ◽  
Vol 233 (2) ◽  
pp. 375-380 ◽  
Author(s):  
Guanglin Cui ◽  
Jing Sun ◽  
Lina Zhang ◽  
Rui Li ◽  
Yan Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Causal Relationship ◽  
Leukocyte Telomere Length

scholarly journals Leukocyte telomere length and risk of coronary heart disease and stroke mortality: prospective evidence from a Russian cohort

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Denes Stefler ◽  
Sofia Malyutina ◽  
Vladimir Maximov ◽  
Pavel Orlov ◽  
Dinara Ivanoschuk ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Stroke Mortality

scholarly journals Correction: Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168868 ◽  
Author(s):  
Sarah E. Goglin ◽  
Ramin Farzaneh-Far ◽  
Elissa S. Epel ◽  
Jue Lin ◽  
Elizabeth H. Blackburn ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Stable Coronary Heart Disease
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