scholarly journals Atypical Presentation of Severe Dengue in a Patient following a Major Abdominal Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Umesh Jayarajah ◽  
Oshan Basnayake ◽  
Kavinda Nagodavithane ◽  
Jayan Jayasinghe ◽  
Dharmabandhu N. Samarasekera

Severe dengue infections in a postoperative patient may lead to significant derangement in the body’s homeostasis resulting in morbidity and sometimes even mortality. Reports on presentation and clinical manifestations of dengue in patients following major surgical procedures are scarce and restricted to few case reports. We describe a 26-year-old male with atypical presentation and late detection of dengue haemorrhagic fever following a major abdominal surgery. On postoperative day 6, he developed spontaneous bleeding from the drain site and moderate-to-massive bilateral pleural effusion with respiratory distress. His dengue IgM and IgG were positive. Therefore, a diagnosis of dengue haemorrhagic fever with bilateral lower zone pneumonia was made. A right-sided intercostal tube was inserted. Intensive care was given and was managed with intravenous antibiotics, targeted fluid therapy, and supportive care. He recovered from the infection and was discharged uneventfully. This case is unique because during the postoperative period, he went into critical phase with significant fluid leakage and developed bleeding manifestations without a clear febrile phase and deterioration in the haemodynamic parameters. High degree of suspicion and early detection are necessary to guide the fluid therapy and provide organ support in such patients.

Author(s):  
Jung-San Chang ◽  
Hung-Chun Chen

Human infections of dengue viruses are mediated by mosquito bites. The disease spectrum ranges from asymptomatic infection to severe dengue haemorrhagic fever, and dengue shock syndrome. Dengue virus infects a wide range of immune cells that lead to plasma leakage and dengue haemorrhagic fever. Dengue haemorrhagic fever can be complicated with renal involvement, including haematuria, proteinuria, glomerulonephritis, acute kidney injury, and haemolytic uraemic syndrome. Diagnosis can be made by serology, detection of viral proteins by Western blot assay, or detection of the dengue viral genome by reverse transcription-polymerase chain reaction. Treatment is mainly supportive. Renal involvement associated with other viral haemorrhagic fevers has mostly been described as case reports and causality has not been established.


2018 ◽  
Vol 35 (9) ◽  
pp. 650-658 ◽  
Author(s):  
Alexandre Joosten ◽  
Sean Coeckelenbergh ◽  
Amelie Delaporte ◽  
Brigitte Ickx ◽  
Jean Closset ◽  
...  

2020 ◽  
Author(s):  
Ping Li ◽  
Sheng-Wen Wu ◽  
Dong-Fang Ge ◽  
Zai-Rong Tang ◽  
Cong-Chao Ma ◽  
...  

Abstract Background: Restrictive fluid therapy is essential to enhanced recovery after surgery. A meta-analysis was conducted to explore the safety of restrictive fluid therapy for major abdominal surgery and compare it with liberal fluid therapy. Methodology : We searched MEDLINE, the Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs), the WHO International Clinical Trials Registry Platform, and EMBASE in which restrictive and liberal fluid therapies were compared. Data on complications, anastomotic leaks, and wound infections were extracted. Results: Eleven RCTs comparing the two therapies were included. Compared with liberal fluid therapy, restrictive fluid therapy lowered the risk of complications and cardiopulmonary dysfunction and had similar rates of mortality, anastomotic leak, pneumonia and would infection. But increased kidney injury was also observed in restrictive fluid therapy. Conclusion: Restrictive fluid therapy is safe but may have potential dangers, so caution is warranted in its application.


Author(s):  
F. Ramasco Rueda ◽  
A. Planas Roca ◽  
A. Figuerola Tejerina ◽  
R. Méndez Hernández ◽  
F. Gilsanz Rodriguez

1959 ◽  
Vol 47 (203) ◽  
pp. 261-274 ◽  
Author(s):  
Winifred F. Young ◽  
John McIntosh ◽  
Valentine Swain ◽  
B. Levin

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Randula Ranawaka ◽  
Chamara Jayamanne ◽  
Kavinda Dayasiri ◽  
Dinuka Samaranayake ◽  
Udara Sandakelum ◽  
...  

Pathogenesis of dengue haemorrhagic fever is not fully understood, but it is thought that there is antibody enhancement during the secondary infection, which causes severe dengue haemorrhagic fever (DHF). Therefore, patients who have DHF should have a documented history of symptomatic dengue infection in the past. A retrospective descriptive-analytical study was conducted at the University Paediatric Unit at Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. All children who had fulfilled the criteria for DHF admitted to the unit from April 2018 to September 2018 were recruited into the study. Relevant data were collected from bed head tickets. One hundred and eighty-four children were included in the final analysis. Thirty-three (17.9%) had a past history of documented symptomatic dengue infection, while 82.1% did not have a documented dengue infection. Twelve patients had dengue shock syndrome, and none of them had previously documented symptomatic dengue fever. Dextran was used in 96 patients in the critical phase. Twelve (42%) patients with past documented symptomatic dengue fever needed dextran while 84 (54.9%) patients without a documented past history of dengue fever needed dextran. In our clinical observation, we noticed that children with DHF mostly did not have a documented symptomatic prior dengue infection, while those with a documented symptomatic prior infection had a milder subsequent illness. In fact, the majority (82.1%) of patients with DHF did not have documented previous symptomatic dengue infection. It was also observed that the clinical course of subsequent dengue infection was less severe in patients with previously documented symptomatic dengue fever. This finding should be further evaluated in a larger scale study minimizing the all-confounding factors. This fact is more important in selecting recipients for vaccines against the dengue virus, which are supposed to produce immunity against the virus without causing the severe disease.


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