scholarly journals The Changes in Blood Flow Seen in the Eye after Foot Acupuncture Treatment in Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Anri Nishinaka ◽  
Koki Nitta ◽  
Takashi Seki ◽  
Hideaki Hara ◽  
Masamitsu Shimazawa
Keyword(s):  
Blood Flow ◽  
Flow Velocity ◽  
Blood Flow Velocity ◽  
Acupuncture Treatment ◽  
Ocular Blood Flow ◽  
Eye Diseases ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Mean Blur Rate ◽  
The Mean

Acupuncture is used to treat a wide variety of eye diseases, although there is little evidence about the effects of acupuncture treatment and the mechanisms responsible for them. Foot acupuncture treatment has effects in both mice and humans. The purpose of this study was to investigate the effects of acupuncture treatment on ocular blood flow in mice. We evaluated ocular blood flow in C57BL/6J mice after foot acupuncture treatment using laser speckle flowgraphy. The mean blur rate, which is an index of blood flow velocity, was increased in the foot acupuncture group. Our results showed that, after 3 minutes’ foot acupuncture, ocular blood flow was significantly increased in both the blood vessels and tissue of the eye in C57BL/6J mice. Thus, performing acupuncture in mice might help to determine its effects. Furthermore, acupuncture is considered to be a possible treatment for ocular disease.

scholarly journals Reproducibility of Neonate Ocular Circulation Measurements Using Laser Speckle Flowgraphy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraclass Correlation ◽  
Ocular Blood Flow ◽  
Eye Diseases ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ocular Circulation ◽  
Time Index ◽  
Mean Blur Rate ◽  
Normal Sleep

Measuring the ocular blood flow in neonates may clarify the relationships between eye diseases and ocular circulation abnormalities. However, no method for noninvasively measuring ocular circulation in neonates is established. We used laser speckle flowgraphy (LSFG) modified for neonates to measure their ocular circulation and investigated whether this method is reproducible. During their normal sleep, we studied 16 subjects (adjusted age of 34–48 weeks) whose blood flow could be measured three consecutive times. While the subjects slept in the supine position, three mean blur rate (MBR) values of the optic nerve head (ONH) were obtained: the MBR-A (mean of all values), MBR-V (vessel mean), and MBR-T (tissue mean), and nine blood flow pulse waveform parameters in the ONH were examined. We analyzed the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) for each parameter. The COVs of the MBR values were all ≤10%. The ICCs of the MBR values were all >0.8. Good COVs were observed for the blowout score, blowout time, rising rate, falling rate, and acceleration time index. Although the measurement of ocular circulation in the neonates was difficult, our results exhibited reproducibility, suggesting that this method could be used in clinical research.

scholarly journals The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shin Takayama ◽  
Yukihiro Shiga ◽  
Taiki Kokubun ◽  
Hideyuki Konno ◽  
Noriko Himori ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Healthy Subjects ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Plain Water ◽  
Mean Blur Rate ◽  
The Mean

The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF). A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas. There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 ± 6.9%,P<0.01). Next, TSS was administered to 19 healthy subjects (mean age: 32.0 ± 11.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration. Plain water was used as a control. OBF increased significantly after TSS administration compared to control (P<0.01) and also increased from 30 to 60 minutes after administration compared to baseline (P<0.05). These results suggest that TSS can increase OBF without affecting BP or IOP in healthy subjects.

scholarly journals Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaku Itoh ◽  
Masato Furuhashi ◽  
Yosuke Ida ◽  
Hiroshi Ohguro ◽  
Megumi Watanabe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Fatty Acid ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Fatty Acid Binding ◽  
High Positive Correlation ◽  
Blood Biochemical

AbstractThe fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. The levels of V-FABP4 and V-VEGFA were significantly higher in PDR patients than in non-PDR patients (P < 0.001) with a high positive correlation (r = 0.72, P < 0.001) between them. The findings were not affected by body mass index values and the presence of vitreous hemorrhaging. Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST. Multiple regression analyses indicated that V-VEGFA, or V-FABP4, AST and HbA1c were independent predictors of V-FABP4 or V-VEGFA, respectively. Both were negatively correlated, but more evident in V-FABP4, with the ONH ocular blood flow.

scholarly journals Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yoshitaka Ueno ◽  
Takeshi Iwase ◽  
Kensuke Goto ◽  
Ryo Tomita ◽  
Eimei Ra ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Adaptive Optics ◽  
Laser Speckle ◽  
The Other ◽  
Systemic Hypertension ◽  
Laser Speckle Flowgraphy ◽  
Retinal Vessels ◽  
External Diameter ◽  
The Mean

AbstractWe investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all P < 0.001). However, the external diameter of the retinal vessels was not significantly different among the groups. The mean blur rate (MBR)-vessel determined by laser speckle flowgraphy was significantly lower in the PDR group than in the other groups (P < 0.001). The WLR was correlated with MBR-vessel (r = − 0.337, P < 0.001), duration of disease (r = 0.191, P = 0.042), stage of DM (r = 0.643, P < 0.001), systolic blood pressure (r = 0.166, P < 0.037), and presence of systemic hypertension (r = 0.443, P < 0.001). Multiple regression analysis demonstrated that MBR-vessel (β = − 0.389, P < 0.001), presence of systemic hypertension (β = 0.334, P = 0.001), and LDL (β = 0.199, P = 0.045) were independent factors significantly associated with the WLR. The increased retinal vessel wall thickness led to a narrowing of lumen diameter and a decrease in the blood flow in the PDR group.

scholarly journals Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates

2016 ◽  
Vol 254 (8) ◽  
pp. 1631-1636 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Postmenstrual Age ◽  
Normal Neonates

scholarly journals A Change in Ocular Circulation after Photocoagulation for Retinopathy of Prematurity in a Neonate

2017 ◽  
Vol 8 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Kotaro Hine ◽  
Yuichi Hori
Keyword(s):  
Optic Nerve ◽  
Retinopathy Of Prematurity ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ocular Circulation ◽  
Before And After ◽  
Photocoagulation Treatment ◽  
The Mean ◽  
The Right

Background: The dilation of veins and tortuosity of arteries that occur in retinopathy of prematurity (ROP) are improved by therapy, and thus posttherapy changes in ocular circulation are also conceivable. We report a case of ROP in which we were able to measure the ocular circulation before and after photocoagulation therapy, using a laser speckle flowgraphy (LSFG) system that is modified for neonates. Case Report: A female infant was born at 25 weeks’ gestation with a birth weight of 808 g. We performed photocoagulation in both eyes at age 15 weeks, and we measured the ocular circulation with the “LSFG-baby” system before and at 12 weeks after the photocoagulation treatment. We also measured the mean blur rate (MBR) in the optic nerve head (ONH) and the relative flow volume (RFV) in the retinal vessels, and we examined the change rates from before to after treatment. The changing rate of the MBR-A (the mean of all values) in the ONH in the right and left eyes was 76.5 and 98.5%, respectively. The vascular RFV in the severe dilation and tortuosity quadrant also tended to decrease. Conclusions: Photocoagulation improved the dilation of veins and tortuosity of arteries and reduced the ocular blood flow in this neonate with ROP. The LSFG-baby system effectively and directly revealed the optic nerve and retinal blood vessels.

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