scholarly journals Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Dongrui Zhou ◽  
Liandi Xie ◽  
Yao Wang ◽  
Shuang Wu ◽  
Fengzhi Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cerebral Infarction ◽  
Bayesian Network ◽  
Clinical Efficacy ◽  
Whole Blood ◽  
Meta Analysis ◽  
Neurological Impairment ◽  
Acute Cerebral Infarction ◽  
Clinical Effects

Western medicine (WM) has certain limitations in terms of treating acute cerebral infarction (ACI), while tonic traditional Chinese medicine injections (TCMIs) have been shown to have obvious clinical effects as an adjunct to WM for ACI. However, most randomized controlled trials (RCTs) to date have not performed direct comparisons of efficacy among tonic TCMIs. This study designed a Bayesian network meta-analysis (NMA) to explore the therapeutic effect of tonic TCMIs on ACI. A comprehensive search of RCTs of TCMIs combined with WM for ACI was conducted using electronic databases for studies dated from the start date of each database until February 2020. Stata 13.0 and ADDIS 1.16.7 software were used to plot and analyze the data. Sixty-six RCTs with a total of 5,989 patients involving 7 kinds of tonic TCMIs were included. Among TCMIs, Shenfu injection (SFI) + WM ranked first in terms of improving clinical efficacy and the activities of daily living (ADLs) rating and reducing interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. While Ciwujia injection (CI) + WM was the best choice for reducing neurological impairment and the high-cut viscosity of whole blood (HCV). Shenmai injection (SI) + WM had the greatest effects in terms of decreasing the levels of low-cut viscosity of whole blood (LCV), fibrinogen (FIB), and plasma viscosity (PV). Based on the cluster analysis of the clinical efficacy and the neurological impairment, CI + WM and Shenqifuzheng (SQI) + WM were the best options for treating ACI. With respect to adverse drug reactions (ADRs), 35 RCTs did not monitor ADRs during treatment. In conclusion, tonic TCMIs could assist WM in benefiting patients with ACI. However, due to the limitations of the current study, strict monitoring of ADRs and data from high-quality RCTs will be required in future to verify the advantage of TCMIs.

scholarly journals Evaluating the Efficacy and Adverse Effects of Clearing Heat and Removing Dampness Method of Traditional Chinese Medicine by Comparison with Western Medicine in Patients with Gout

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Nan Xiao ◽  
Hao Chen ◽  
Shi-Yong He ◽  
Chong-Xiang Xue ◽  
Hua Sui ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Clinical Efficacy ◽  
Western Medicine ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Clinical Effects ◽  
China National Knowledge Infrastructure ◽  
Randomized Controlled Clinical Trials ◽  
Randomized Controlled

Objective. In China, the method of clearing heat and removing dampness medicine of Chinese traditional medicine has been widely used on gout. However, the clinical effects are various and not summarized systematically. Methods. In this study, a large number of randomized controlled clinical trials were reviewed and analyzed and the clinical efficacy and adverse reactions of traditional Chinese medicine with clearing heat and removing dampness effects for the treatment of gout were systematically evaluated. A comprehensive search of databases including pubMed, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, Wanfang Data, and SinoMed was performed. Results. There are 69 randomized controlled trials with 5915 sample sizes meeting the criteria in the study. The results of the meta-analysis indicate that the effects of clearing heat and removing dampness medicine were slightly better than western medicine in the treatment of gout based on the following parameters: serum uric acid (standardized mean difference (SMD):-62.14, 95% confidence interval (CI): -78.12 to-46.15), C reactive protein (SMD: -4.21, 95% CI: -6.19 to -2.23), erythrocyte sedimentation rate (SMD: -6.23, 95% CI: -8.39 to-4.06), and overall clinical response (relative risk (RR): 1.11, 95% CI: 1.08 to 1.15) and, in the profile of adverse drug reactions, the clearing heat and removing dampness medicine showed less adverse reactions than traditional Western medicine (RR: 0.18, 95% CI: 0.10 to 0.32). Conclusions. Through a systemic evaluation of the clinical efficacy of the clearing heat and removing dampness medicine of traditional Chinese medicine and western medicine on gout, the clearing heat and removing dampness medicine and western medicine possessed similar clinical efficacy, but traditional Chinese medicine treatments are superior to western medicine in controlling adverse reactions.

scholarly journals Comparative study of xuesaitong injection and compound salvia miltiorrhizae injection in the treatment of acute cerebral infarction: a meta-analysis

2019 ◽  
Vol 47 (11) ◽  
pp. 5375-5388
Author(s):  
Xiaojiao Duan ◽  
Dan Zhang ◽  
Kaihuan Wang ◽  
Jiarui Wu ◽  
Xiaomeng Zhang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Shear Viscosity ◽  
Whole Blood ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Neurological Impairment ◽  
Effective Rate ◽  
Plasma Viscosity ◽  
Acute Cerebral Infarction ◽  
Salvia Miltiorrhizae

Objective This study was conducted to systematically evaluate the clinical effectiveness of xuesaitong injection (XST) and compound salvia miltiorrhizae injection (CSM) in the treatment of acute cerebral infarction (ACI). Methods We searched several databases for randomized controlled trials (RCTs) using XST and CSM for the treatment of ACI. Two researchers independently selected the RCTs and extracted information. The quality of included RCTs was evaluated, and then data were analyzed using RevMan5.3 and STATA 12.0 software. Results Twenty-three RCTs that enrolled 2101 participants were included in this study. A meta-analysis showed that XST with routine Western medicine (WM) can achieve a better effect than CSM with WM for the total effective rate ( RR = 1.22, 95% CI: 1.18–1.27). In addition, XST combined with WM could improve neurological impairment ( MD = −4.65, 95% CI: −7.85 – −1.44) and hemorheological parameters. XST decreased the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and plasma fibrinogen. Conclusions For treating ACI, XST combined with WM was more effective than CSM with WM. However, more evidence is needed to support the safety of XST and CSM.

scholarly journals Clinical Evidence-Based Evaluation of ZFXNY in Treatment of Acute Cerebral Infarction

2021 ◽  
Author(s):  
Wei Hu ◽  
Chenhui Zhang ◽  
Hong Zhang
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cerebral Infarction ◽  
Controlled Trial ◽  
Case Fatality ◽  
Test Group ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Chronic Obstructive ◽  
Evidence Based

Abstract Background: Stroke is a severe and life-threatening disease, owns high rates of disability and mortality.[1] Stroke and ischemic heart disease, chronic obstructive pulmonary disease are the world’s three main killers.Ischemic strokes account for the vast majority of strokes.[2] Modern medicine has some advantages in treating ischemic stroke, but there are also limitations. Traditional Chinese medicine has thousands of years of experience in treating stroke, but there are few high quality clinical Randomized controlled trial.Methods: This is a multicenter, randomized, double-blind, placebo-controlled trial. 286 patients were randomly divided into test group and Control Group. Both groups received General Western medicine treatment, the test group combined with Chinese medicine treatment, the control group combined with placebo treatment. The duration of treatment was 30 days and the follow-up was 90 days. evaluation indicators include: Modified Rankin Scale, NIH stroke Scale, Glasgow Coma Scale, Barthel Index, Case fatality rate.Laboratory specifications and safety assessments will also be taken into account.Discussion: The aim of this study was to evaluate the safety and efficacy of ZFXNY in the treatment of acute cerebral infarction. Our research will provide a reliable evidence-based medicine basis for the treatment of acute cerebral infarction with traditional Chinese medicine, and provide another option for the treatment of acute cerebral infarction.Trial registration: ChiCTR2100043796, Registered February 28th, 2021.

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