scholarly journals Comparative study of xuesaitong injection and compound salvia miltiorrhizae injection in the treatment of acute cerebral infarction: a meta-analysis

2019 ◽  
Vol 47 (11) ◽  
pp. 5375-5388
Author(s):  
Xiaojiao Duan ◽  
Dan Zhang ◽  
Kaihuan Wang ◽  
Jiarui Wu ◽  
Xiaomeng Zhang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Shear Viscosity ◽  
Whole Blood ◽  
Meta Analysis ◽  
Clinical Effectiveness ◽  
Neurological Impairment ◽  
Effective Rate ◽  
Plasma Viscosity ◽  
Acute Cerebral Infarction ◽  
Salvia Miltiorrhizae

Objective This study was conducted to systematically evaluate the clinical effectiveness of xuesaitong injection (XST) and compound salvia miltiorrhizae injection (CSM) in the treatment of acute cerebral infarction (ACI). Methods We searched several databases for randomized controlled trials (RCTs) using XST and CSM for the treatment of ACI. Two researchers independently selected the RCTs and extracted information. The quality of included RCTs was evaluated, and then data were analyzed using RevMan5.3 and STATA 12.0 software. Results Twenty-three RCTs that enrolled 2101 participants were included in this study. A meta-analysis showed that XST with routine Western medicine (WM) can achieve a better effect than CSM with WM for the total effective rate ( RR = 1.22, 95% CI: 1.18–1.27). In addition, XST combined with WM could improve neurological impairment ( MD = −4.65, 95% CI: −7.85 – −1.44) and hemorheological parameters. XST decreased the whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, and plasma fibrinogen. Conclusions For treating ACI, XST combined with WM was more effective than CSM with WM. However, more evidence is needed to support the safety of XST and CSM.

scholarly journals Evaluation of efficacy and safety of Reteplase and Alteplase in the treatment of hyper-acute cerebral infarction

2018 ◽  
Vol 38 (1) ◽  
Author(s):  
Zhi-Jian Lin ◽  
Hong-Yan Qiu ◽  
Xiao-Xin Tong ◽  
Yi Guo ◽  
Man-Fu Han ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Shear Viscosity ◽  
Whole Blood ◽  
Adverse Reactions ◽  
Density Lipoprotein ◽  
Plasma Viscosity ◽  
Acute Cerebral Infarction ◽  
Lipoprotein Cholesterol ◽  
Efficacy And Safety ◽  
K Value

Objective: The present study aimed to investigate the efficacy and safety of Reteplase (rPA) and Alteplase (rt-PA) in the treatment of hyper-acute cerebral infarction (CI). Methods: Six hundred and eleven patients with hyper-acute CI selected from September 2014 to September 2016 were assigned into the aspirin, rt-PA, rPA, rt-PA + aspirin, and rPA + aspirin groups based on their willingness. The difference of efficacy in five groups were evaluated with National Institute of Health Stroke Scale (NIHSS), modified rankin scale (mRS), and Barthel Index (BI). Coagulation function, blood lipid, and hemodynamics were analyzed. The safety differences were compared by observing the adverse reactions. Results: Compared with the rt-PA, rPA, and aspirin groups, NIHSS score, mRS score, the incidence of non- and symptomatic cerebral hemorrhage as well as the rate of adverse reactions were decreased, while BI were increased in the rt-PA + aspirin and rPA + aspirin groups after treatment. Compared with the rt-PA and rPA groups, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were lower, whereas the hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte electrophoresis time, fibrinogen, erythrocyte sedimentation rate (ESR), K value in blood sedimentation equation, and the comprehensive abnormality degree of blood rheology were higher in the rt-PA + aspirin and rPA + aspirin groups. Conclusion: The efficacy and safety of rt-PA or rPA combined with aspirin in the treatment of hyper-acute CI were better than those of rPA or rt-PA monotherapy.

scholarly journals Clinical Efficacy of Tonic Traditional Chinese Medicine Injection on Acute Cerebral Infarction: A Bayesian Network Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Dongrui Zhou ◽  
Liandi Xie ◽  
Yao Wang ◽  
Shuang Wu ◽  
Fengzhi Liu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cerebral Infarction ◽  
Bayesian Network ◽  
Clinical Efficacy ◽  
Whole Blood ◽  
Meta Analysis ◽  
Neurological Impairment ◽  
Acute Cerebral Infarction ◽  
Clinical Effects

Western medicine (WM) has certain limitations in terms of treating acute cerebral infarction (ACI), while tonic traditional Chinese medicine injections (TCMIs) have been shown to have obvious clinical effects as an adjunct to WM for ACI. However, most randomized controlled trials (RCTs) to date have not performed direct comparisons of efficacy among tonic TCMIs. This study designed a Bayesian network meta-analysis (NMA) to explore the therapeutic effect of tonic TCMIs on ACI. A comprehensive search of RCTs of TCMIs combined with WM for ACI was conducted using electronic databases for studies dated from the start date of each database until February 2020. Stata 13.0 and ADDIS 1.16.7 software were used to plot and analyze the data. Sixty-six RCTs with a total of 5,989 patients involving 7 kinds of tonic TCMIs were included. Among TCMIs, Shenfu injection (SFI) + WM ranked first in terms of improving clinical efficacy and the activities of daily living (ADLs) rating and reducing interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels. While Ciwujia injection (CI) + WM was the best choice for reducing neurological impairment and the high-cut viscosity of whole blood (HCV). Shenmai injection (SI) + WM had the greatest effects in terms of decreasing the levels of low-cut viscosity of whole blood (LCV), fibrinogen (FIB), and plasma viscosity (PV). Based on the cluster analysis of the clinical efficacy and the neurological impairment, CI + WM and Shenqifuzheng (SQI) + WM were the best options for treating ACI. With respect to adverse drug reactions (ADRs), 35 RCTs did not monitor ADRs during treatment. In conclusion, tonic TCMIs could assist WM in benefiting patients with ACI. However, due to the limitations of the current study, strict monitoring of ADRs and data from high-quality RCTs will be required in future to verify the advantage of TCMIs.

scholarly journals Efficacy of Ligustrazine Injection as Adjunctive Therapy in Treating Acute Cerebral Infarction: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Huikai Shao ◽  
Xia He ◽  
Lijuan Zhang ◽  
Shan Du ◽  
Xiaoqing Yi ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Blood Viscosity ◽  
Western Medicine ◽  
Adjunctive Therapy ◽  
Methodological Quality ◽  
Outcome Measure ◽  
Meta Analysis ◽  
Effective Rate ◽  
Acute Cerebral Infarction

Background: Ligustrazine injection has been widely used as adjunctive therapy in the treatment of acute cerebral infarction (ACI) during the past decades in China, but its clinical efficacy is not yet well confirmed. This study aims to evaluate the efficacy of ligustrazine injection as adjunctive therapy for ACI.Methods: Databases including China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), PubMed, Medline, Google Scholar, Chinese Biomedical Literature Database, Cochrane Library, Embase, Sino-Med, Wanfang Database, and Chinese Science Citation Database were systematically searched for the published randomized controlled trials (RCTs) on ligustrazine injection in the treatment of ACI until November 2020. Meta-analysis was performed on the primary outcome measure (i.e., clinical effective rate) and the secondary outcome measure [i.e., neurological deficit score (NDS), fibrinogen, low shear blood viscosity (LBV), and high shear blood viscosity (HBV)]. The quality of the included RCTs was assessed according to the M scoring system (the refined Jadad scale). Sensitivity analysis and subgroup analysis were conducted according to the methodological quality, years of publication, and sample size.Results: Nineteen RCTs, containing 2022 patients, were included in this study. Meta-analysis indicated that ligustrazine injection combined with Western medicine could achieve a better effect in the treatment of ACI than using Western medicine alone in terms of clinical effective rate (RR = 1.24; 95% CI, 1.19–1.29), NDS (MD = −3.88; 95%CI, −4.51 to −3.61), fibrinogen (MD = −0.59; 95% CI, −0.76 to −0.42), LBV (MD = −2.11; 95% CI, −3.16 to −1.06), and HBV (MD = −0.88; 95% CI, −1.20 to −0.55).Conclusions: This research indicated that ligustrazine injection as adjunctive therapy seemed to be more effective than using western medicine alone in treating ACI. However, more evidence is required to confirm the efficacy of ligustrazine injection due to the low methodological quality of the included RCTs.

scholarly journals Continuous Lumbar Plexus Block under the Guidance of the “Shamrock Method” Ultrasound: Analgesic Effects and Hemodynamic Effects after Total Knee Arthroplasty in Elderly Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jinpei Xue ◽  
Xiang Fu ◽  
Zurong Hu
Keyword(s):  
Elderly Patients ◽  
Shear Viscosity ◽  
Whole Blood ◽  
Sensory Nerve ◽  
Onset Time ◽  
Plasma Viscosity ◽  
Lumbar Plexus ◽  
Nerve Blocks ◽  
Lumbar Plexus Block ◽  
Plexus Block

Objective. To explore the effect of continuous lumbar plexus block guided by the “Shamrock method” on postoperative analgesia and hemodynamics in elderly patients after total knee arthroplasty (TKA). Methods. From January 2020 to December 2020 in our hospital, 98 patients who underwent TKA were selected. Using the random number table method, the patients were divided into two groups: a continuous lumbar plexus block group (group L), with 49 patients, and a continuous femoral nerve block group (group F), with 49 patients. The onset time and maintenance time of motor and sensory nerve blocks in patients were recorded. A visual analogue scale (VAS) was applied to assess the pain severity at 6, 12, 24, and 48 h after the operation. The VAS score (FVAS) was applied to evaluate the pain severity of the patients during 24 and 48 h after the operation and knee joint functional exercise. The levels of hemodynamic indexes such as heart rate, mean arterial pressure, and oxyhemoglobin saturation and the levels of hemorheological indexes such as plasma viscosity, high and low whole blood shear viscosity, fibrinogen, and hematocrit were detected and compared between the two groups immediately after the operation and at 12 h and 48 h after the operation, respectively. The incidence of adverse reactions induced by anesthesia was counted. Results. The onset time of motor and sensory nerve blocks in group L was lower than that in group F, and the maintenance time was higher than that in group F ( P < 0.05 ). The VAS scores of 6, 12, 24, and 48 h after operation in group L were significantly lower than those in group F ( P < 0.05 ). The FVAS scores of group L at 24 and 48 h after operation were significantly lower than those of group F ( P < 0.05 ). The heart rates of the patients in the two groups were higher at 12 h and 48 h after operation than those immediately after operation ( P < 0.05 ). The heart rates at 12 h and 48 h after operation in group L were lower than those in group F ( P < 0.05 ). The plasma viscosity, high whole blood shear viscosity, and low whole blood shear viscosity in the group L at 12 h and 48 h after operation were lower than those in group F ( P < 0.05 ). There was no significant difference in the incidence of local anesthetic poisoning, nausea, vomiting, urinary retention, pruritus, and other adverse reactions between the two groups ( P > 0.05 ). Conclusion. The “Shamrock method” ultrasound-guided continuous lumbar plexus block in elderly patients after TKA has good analgesic effect, stable hemodynamics, little influence on hemorheology, and good safety. It is of great value to enhance the surgical effect and promote postoperative rehabilitation.

scholarly journals Edaravone Combined with Clopidogrel Is Beneficial to Improve Efficacy, Neurological Impairment, and Life Function in Acute Cerebral Infarction Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Liao Wu ◽  
Ying Sun ◽  
Guihua Ni ◽  
Bo Sun ◽  
Xiaoyu Ni ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Neurological Deficit ◽  
Daily Living ◽  
Adverse Reactions ◽  
Neurological Impairment ◽  
Acute Cerebral Infarction ◽  
Control Group ◽  
Nihss Score ◽  
Cerebral Hemodynamic ◽  
Life Function

Objective. This research aimed at investigating the efficacy of edaravone combined with clopidogrel on acute cerebral infarction (ACI) and its influence on the neurological deficit and life function. Methods. Totally, 154 ACI cases were included and then divided into the control group (CG) (n = 71) and research group (RG) (n = 83) according to the treatment methods. Patients in the CG were treated with clopidogrel alone, and those in the RG were under edaravone-clopidogrel combination therapy. The efficacy, adverse reactions, NIHSS score, cerebral hemodynamic indexes, and Fugl-Meyer scale (FMA) and Barthel index (BI) of activities of daily living (ADL) scores were observed. Results. Compared with before treatment, the symptoms of both groups were improved after treatment: the NIHSS scores decreased, FMA and ADL scores increased, and cerebral hemodynamic indexes were improved. Compared with the CG, the efficacy and cerebral hemodynamic indexes of the RG were better, the adverse reactions were equivalent, the NIHSS score was lower, and the ADL and FMA scores were higher. Conclusion. Edaravone combined with clopidogrel can effectively treat ACI and improve the neurological deficit and life function of patients.

scholarly journals Carotid plaques and neurological impairment in patients with acute cerebral infarction

PLoS ONE ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. e0226961
Author(s):  
Tongtian Ni ◽  
Yi Fu ◽  
Wei Zhou ◽  
Min Chen ◽  
Jianwei Shao ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Neurological Impairment ◽  
Acute Cerebral Infarction ◽  
Carotid Plaques

scholarly journals Meta-analysis of defibrase in treatment of acute cerebral infarction

2006 ◽  
Vol 119 (8) ◽  
pp. 662-668 ◽  
Author(s):  
Yi GUO ◽  
Yan-fang ZUO ◽  
Qi-zhang WANG ◽  
Bing-shan TANG ◽  
Fu-kang LI ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Meta Analysis ◽  
Acute Cerebral Infarction

Effectiveness of Acupuncture in Postpartum Depression: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 36 (5) ◽  
pp. 295-301 ◽  
Author(s):  
Shanshan Li ◽  
Weiqiang Zhong ◽  
Wen Peng ◽  
Gaofeng Jiang
Keyword(s):  
Postpartum Depression ◽  
Rating Scale ◽  
Meta Analysis ◽  
Depression Scale ◽  
Cochrane Collaboration ◽  
Clinical Effectiveness ◽  
Effective Rate ◽  
Cochrane Library ◽  
Secondary Outcome ◽  
Control Group

Objective To assess the clinical effectiveness of acupuncture in the treatment of postpartum depression (PPD). Methods The following electronic databases were systematically searched: PubMed, Cochrane Library, SCI, Elsevier SDOL, China National Knowledge, Wan Fang database and Chinese Science and Technology Periodical Database. Only randomised controlled trials (RCTs) of acupuncture for PPD were considered. Primary outcomes were the Hamilton Rating Scale for Depression (HAMD) or the Edinburgh Postnatal Depression Scale (EPDS) scores and effective rate. Our secondary outcome was the level of oestradiol. The quality of all included trials was evaluated according to the Cochrane Collaboration. This protocol was registered in PROSPERO (CRD42016048528). Results Nine trials involving 653 women were selected. The result of this meta-analysis demonstrated that the acupuncture group had a significantly greater overall effective rate compared with the control group (seven trials, n=576, I2=24%; relative risk (RR) 1.15, 95% CI 1.06 to 1.24; P<0.001). Moreover, acupuncture significantly increased oestradiol levels compared with the control group (mean difference (MD) 36.92, 95% CI 23.14 to 50.71, P<0.001). Regarding the HAMD and EPDS scores, no difference was found between the two groups (five trials, n=276, I2=82%; MD−1.38, 95% CI −3.40 to 0.64; P=0.18; two trials, n=60, I2=16%; MD 1.08, 95% CI −1.09 to 3.26; P=0.33). Conclusions Acupuncture appears to be effective for postpartum depression with respect to certain outcomes. However, the evidence thus far is inconclusive. Further high-quality RCTs following standardised guidelines with a low risk of bias are needed to confirm the effectiveness of acupuncture for postpartum depression.

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