Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury

Acute kidney injury (AKI) is a heterogeneous syndrome characterized by a dramatic increase in serum creatinine. Mild AKI may merely be confined to kidney damage and resolve within days; however, severe AKI commonly involves extrarenal organ dysfunction and is associated with high mortality. There is no specific pharmaceutical treatment currently available that can reverse the course of this disease. Notably, mesenchymal stem cells (MSCs) show great promise for the management of AKI by targeting multiple pathophysiological pathways to facilitate tubular epithelial cell repair. It has been well established that the unique characteristics of MSCs make them ideal vectors for gene therapy. Thus, genetic modification has been attempted to achieve improved therapeutic outcomes in the management of AKI by overexpressing trophic cytokines or facilitating MSC delivery to renal tissues. The present article provides a comprehensive review of genetic modification strategies targeted at optimizing the therapeutic potential of MSCs in AKI.

Download Full-text

Genetic Modification of Mesenchymal Stem Cells to Overexpress CXCR4 and CXCR7 Does Not Improve the Homing and Therapeutic Potentials of These Cells in Experimental Acute Kidney Injury

Stem Cells and Development ◽

10.1089/scd.2011.0588 ◽

2012 ◽

Vol 21 (16) ◽

pp. 2969-2980 ◽

Cited By ~ 34

Author(s):

Yousof Gheisari ◽

Kayhan Azadmanesh ◽

Naser Ahmadbeigi ◽

Seyed Mahdi Nassiri ◽

Azadeh Fahim Golestaneh ◽

...

Keyword(s):

Stem Cells ◽

Acute Kidney Injury ◽

Mesenchymal Stem Cells ◽

Genetic Modification ◽

Kidney Injury

Download Full-text

Therapeutic potential of mesenchymal stem cells in acute kidney injury is affected by administration timing

Acta Biochimica et Biophysica Sinica ◽

10.1093/abbs/gmx016 ◽

2017 ◽

Vol 49 (4) ◽

pp. 338-348 ◽

Cited By ~ 11

Author(s):

Xiaoyan Liu ◽

Jieru Cai ◽

Xiaoyan Jiao ◽

Xiaofang Yu ◽

Xiaoqiang Ding

Keyword(s):

Stem Cells ◽

Acute Kidney Injury ◽

Mesenchymal Stem Cells ◽

Therapeutic Potential ◽

Kidney Injury ◽

Administration Timing

Download Full-text

Faculty Opinions recommendation of Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717959864.793463065 ◽

2012 ◽

Author(s):

Michael Mayr ◽

Patrizia Amico

Keyword(s):

Stem Cells ◽

Acute Kidney Injury ◽

Mesenchymal Stem Cells ◽

Kidney Injury

Download Full-text

Comparative study of allogenic and xenogeneic mesenchymal stem cells on cisplatin-induced acute kidney injury in Sprague-Dawley rats

Stem Cell Research & Therapy ◽

10.1186/s13287-016-0386-0 ◽

2016 ◽

Vol 7 (1) ◽

Cited By ~ 21

Author(s):

Rehab H. Ashour ◽

Mohamed-Ahdy Saad ◽

Mohamed-Ahmed Sobh ◽

Fatma Al-Husseiny ◽

Mohamed Abouelkheir ◽

...

Keyword(s):

Stem Cells ◽

Acute Kidney Injury ◽

Mesenchymal Stem Cells ◽

Comparative Study ◽

Kidney Injury ◽

Sprague Dawley ◽

Sprague Dawley Rats

Download Full-text

Extracellular vesicles derived from mesenchymal stem cells as a potential therapeutic agent in acute kidney injury (AKI) in felines: review and perspectives

Stem Cell Research & Therapy ◽

10.1186/s13287-021-02573-6 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Magdalena M. Kraińska ◽

Natalia Pietrzkowska ◽

Eliza Turlej ◽

Li Zongjin ◽

Krzysztof Marycz

Keyword(s):

Stem Cells ◽

Acute Kidney Injury ◽

Mesenchymal Stem Cells ◽

Extracellular Vesicles ◽

Kidney Injury ◽

Cargo Transport ◽

Potential Benefits ◽

Apoptotic Effects ◽

Different Sources ◽

Modern Tool

AbstractMesenchymal stem cells (MSCs), known from their key role in the regeneration process of tissues, and their abilities to release bioactive factors like extracellular vesicles (EVs) could be considered as a potential, modern tool in the treatment of AKI (acute kidney injury) in both human and veterinary patients. The complex pathophysiology of a renal function disorder (AKI) makes difficult to find a universal therapy, but the treatment strategy is based on MSCs and derived from them, EVs seem to solve this problem. Due to their small size, the ability of the cargo transport, the ease of crossing the barriers and the lack of the ability to proliferate and differentiate, EVs seem to have a significant impact on the development such therapy. Their additional impact associated with their ability to modulate immune response and inflammation process, their strong anti-fibrotic and anti-apoptotic effects and the relation with the releasing of the reactive oxygen species (ROS), that pivotal role in the AKI development is undoubtedly, limits the progress of AKI. Moreover, the availability of EVs from different sources encourages to extend research with using EVs from MSCs in AKI treatment in felines; in that, the possibilities of kidney injuries treatment are still limited to the classical therapies burdened with dangerous side effects. In this review, we underline the significance of the processes, in whose EVs are included during the AKI in order to show the potential benefits of EVs-MSCs-based therapies against AKI in felines.

Download Full-text

Stem cell-based treatment of kidney diseases

Experimental Biology and Medicine ◽

10.1177/1535370220915901 ◽

2020 ◽

Vol 245 (10) ◽

pp. 902-910

Author(s):

Binbin Pan ◽

Guoping Fan

Keyword(s):

Chronic Kidney Disease ◽

Stem Cells ◽

Acute Kidney Injury ◽

Stem Cell ◽

Kidney Disease ◽

Cell Therapy ◽

Kidney Diseases ◽

Kidney Injury ◽

Great Promise ◽

Kidney Organoids

Kidney dysfunction, including chronic kidney disease and acute kidney injury, is a globally prevalent health problem. However, treatment regimens are still lacking, especially for conditions involving kidney fibrosis. Stem cells hold great promise in the treatment of chronic kidney disease and acute kidney injury, but success has been hampered by insufficient incorporation of the stem cells in the injured kidney. Thus, new approaches for the restoration of kidney function after acute or chronic injury have been explored. Recently, kidney organoids have emerged as a useful tool in the treatment of kidney diseases. In this review, we discuss the mechanisms and approaches of cell therapy in acute kidney injury and chronic kidney disease, including diabetic kidney disease and lupus nephritis. We also summarize the potential applications of kidney organoids in the treatment of kidney diseases. Impact statement Stem cells hold great promise in regenerative medicine. Pluripotent stem cells have been differentiated into kidney organoids to understand human kidney development and to dissect renal disease mechanisms. Meanwhile, recent studies have explored the treatment of kidney diseases using a variety of cells, including mesenchymal stem cells and renal derivatives. This mini-review discusses the diverse mechanisms underlying current renal disease treatment via stem cell therapy. We postulate that clinical applications of stem cell therapy for kidney diseases can be readily achieved in the near future.

Download Full-text