scholarly journals Association between 25-Hydroxyvitamin D and Metabolic Syndrome in Older Adults: The Health, Aging and Body Composition Study

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Subhashish Agarwal ◽  
Janet A. Tooze ◽  
Douglas C. Bauer ◽  
Jane A. Cauley ◽  
Tamara B. Harris ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Renal Function ◽  
Hydroxyvitamin D ◽  
Body Composition Study ◽  
Health Aging ◽  
25 Hydroxyvitamin D ◽  
Composition Study ◽  
Design And Methods

Objective. Low 25-hydroxyvitamin D (25[OH]D) levels and metabolic syndrome (MetS) are prevalent among older adults; however, longitudinal studies examining 25(OH)D status and MetS are lacking. We explore the association of 25(OH)D levels with prevalent and incident MetS in white and black older adults. Research Design and Methods. A total of 1620 white and 1016 black participants aged 70–79 years from the Health ABC cohort with measured 25(OH)D levels and data on MetS and covariates of interest were examined. The association between 25(OH)D levels and prevalent MetS at baseline and incident MetS at 6-year follow-up was examined in whites and blacks separately using logistic regression adjusting for demographics, lifestyle factors, and renal function. Results. At baseline, 635 (39%) white and 363 (36%) black participants had prevalent MetS. In whites, low 25(OH)D levels were associated with prevalent MetS (adjusted OR (95% CI), 1.85 (1.47, 2.34)) and 1.96 (1.46, 2.63) for 25(OH)D of 20–<30 and <20 vs. ≥30 ng/ml, respectively). The association was attenuated after adjustment for BMI but remained significant. No association was found between 25(OH)D levels and prevalent MetS in blacks. Among those without MetS at baseline (765 whites, 427 blacks), 150 (20%) whites and 87 (20%) blacks had developed MetS at 6-year follow-up. However, 25(OH)D levels were not associated with incident MetS in whites or blacks. Conclusion. In older adults, low 25(OH)D levels were associated with increased odds of prevalent MetS in whites but not in blacks. No association was observed between 25(OH)D levels and incident MetS in either whites or blacks.

scholarly journals Relationship Between 25-Hydroxyvitamin D and Cognitive Function in Older Adults: The Health, Aging and Body Composition Study

2014 ◽  
Vol 62 (4) ◽  
pp. 636-641 ◽  
Author(s):  
Valerie K. Wilson ◽  
Denise K. Houston ◽  
Laurel Kilpatrick ◽  
James Lovato ◽  
Kristine Yaffe ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Composition ◽  
Cognitive Function ◽  
Hydroxyvitamin D ◽  
Body Composition Study ◽  
Health Aging ◽  
25 Hydroxyvitamin D ◽  
Composition Study

scholarly journals Low 25-Hydroxyvitamin D Concentrations Predict Incident Depression in Well-Functioning Older Adults: The Health, Aging, and Body Composition Study

2014 ◽  
Vol 70 (6) ◽  
pp. 757-763 ◽  
Author(s):  
Julie A. Williams ◽  
Kaycee M. Sink ◽  
Janet A. Tooze ◽  
Hal H. Atkinson ◽  
Jane A. Cauley ◽  
...  
Keyword(s):  
Older Adults ◽  
Body Composition ◽  
Hydroxyvitamin D ◽  
Body Composition Study ◽  
Health Aging ◽  
25 Hydroxyvitamin D ◽  
Composition Study

scholarly journals Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Suruchi Mishra ◽  
Tamara B. Harris ◽  
Trisha Hue ◽  
Iva Miljkovic ◽  
Suzanne Satterfield ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Older Women ◽  
Subcutaneous Fat ◽  
Abdominal Adiposity ◽  
Multivariate Logistic Regression ◽  
Body Composition Study ◽  
Health Aging ◽  
Prospective Association

Background. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines.Methods. The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cytokines, BMI, total percent fat, and visceral and subcutaneous fat. Multivariate logistic regression was used to determine the association between leptin and metabolic syndrome (defined per NCEP ATP III) incidence after 6 years of follow-up among 1,120 men and women.Results. Leptin predicted metabolic syndrome in men (Pfor trend = 0.0002) and women (Pfor trend = 0.0001). In women, risk of metabolic syndrome increased with higher levels of leptin (compared with quintile 1, quintile 2 RR = 3.29, CI = 1.36, 7.95; quintile 3 RR = 3.25, CI = 1.33, 7.93; quintile 4 RR = 5.21, CI = 2.16, 12.56; and quintile 5 RR = 7.97, CI = 3.30, 19.24) after adjusting for potential confounders. Leptin remained independently associated with metabolic syndrome risk after additional adjustment for adiposity, cytokines, and CRP. Among men, this association was no longer significant after controlling for adiposity.Conclusion. Among older women, elevated concentrations of leptin may increase the risk of metabolic syndrome independent of adiposity and cytokines.

scholarly journals Olfaction and incident Parkinson disease in US white and black older adults

Neurology ◽  
2017 ◽  
Vol 89 (14) ◽  
pp. 1441-1447 ◽  
Author(s):  
Honglei Chen ◽  
Srishti Shrestha ◽  
Xuemei Huang ◽  
Samay Jain ◽  
Xuguang Guo ◽  
...  
Keyword(s):  
Older Adults ◽  
Parkinson Disease ◽  
Cox Models ◽  
Body Composition Study ◽  
Multiple Data ◽  
Hazard Ratios ◽  
Health Aging ◽  
Study Participants ◽  
Smell Identification

Objective:To investigate olfaction in relation to incident Parkinson disease (PD) in US white and black older adults.Methods:The study included 1,510 white (mean age 75.6 years) and 952 black (75.4 years) participants of the Health, Aging, and Body Composition study. We evaluated the olfaction of study participants with the Brief Smell Identification Test (BSIT) in 1999–2000. We retrospectively adjudicated PD cases identified through August 31, 2012, using multiple data sources. We used multivariable Cox models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Results:During an average of 9.8 years of follow-up, we identified a total of 42 incident PD cases, including 30 white and 12 black participants. Overall, poor sense of smell, as indicated by a lower BSIT score, was associated with higher risk of PD. Compared with the highest tertile of BSIT (t3), the HR was 1.3 (95% CI 0.5–3.6) for the second tertile (t2) and 4.8 (95% CI 2.0–11.2) for the lowest tertile (t1) (ptrend < 0.00001). Further analyses revealed significant associations for incident PD in both the first 5 years of follow-up (HRt1/[t2+t3] 4.2, 95% CI 1.7–10.8) and thereafter (HRt1/[t2+t3] 4.1, 95% CI 1.7–9.8). This association appeared to be stronger in white (HRt1/[t2+t3] 4.9, 95% CI 2.3–10.5) than in black participants (HRt1/[t2+t3] 2.5, 95% CI 0.8–8.1), and in men (HRt1/[t2+t3] 5.4, 95% CI 2.3–12.9) than in women (HRt1/[t2+t3] 2.9, 95% CI 1.1–7.8).Conclusions:Poor olfaction predicts PD in short and intermediate terms; the possibility of stronger associations among men and white participants warrants further investigation.

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