scholarly journals Application of Recombinant Human BMP-2 with Bone Marrow Aspirate Concentrate and Platelet-Rich Fibrin in Titanium Mesh for Vertical Maxillary Defect Reconstruction prior to Implant Placement

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Kamel Alraei ◽  
Jameel Shrqawi ◽  
Khawlah Alarusi
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Bone Defects ◽  
Graft Material ◽  
Titanium Mesh ◽  
Term Survival ◽  
Maxillary Bone ◽  
Platelet Rich Fibrin ◽  
Bone Marrow Aspirate Concentrate ◽  
Maxillary Defect

Recombinant human bone morphogenetic protein 2 (rhBMP-2) is an alternative bone substitute for extensive maxillary bone defects which avoids the disadvantages associated with other grafting materials. This report details a case of a 32-year-old female with a severe vertical and horizontal maxillary bony defect that developed after tumor removal. She underwent two unsuccessful regenerative surgeries with an iliac bone graft. Reconstruction of the maxillary defect was planned by offlabel use of rhBMP-2/absorbable collagen sponge (ACS) combined with a bone marrow aspirate concentrate (BMAC) and allograft in a titanium mesh covered in platelet-rich fibrin (PRF). Clinical and radiographic evaluations showed good quality and quantity of bone formation, and she was rehabilitated with dental implants and prosthodontic treatment. Based on this case, the use of rhBMP-2 as a graft material appears encouraging with a satisfying outcome. The present case is aimed at reporting the clinical and radiographic effectiveness of rhBMP-2/ACS in combination with PRF and a titanium mesh for severe maxillary bone defects. Future investigations will be required to ascertain the long-term survival of implants in areas grafted with rhBMP-2.

scholarly journals Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Kamel Alraei ◽  
Jameel Sharqawi ◽  
Somaya Harcher ◽  
Ibrahim Ghita
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Maxillofacial Surgery ◽  
Tumor Resection ◽  
Bone Morphogenetic Protein 2 ◽  
Oral And Maxillofacial Surgery ◽  
Titanium Mesh ◽  
Bone Marrow Aspirate Concentrate ◽  
Human Bone Morphogenetic Protein ◽  
Pindborg Tumor

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery. It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects. In this study, we report a case of a large Pindborg tumor involving the left mandible. The treatment consisted of surgical resection, followed by off-label use of rhBMP-2 in addition to bone marrow aspirate concentrate, together with an allograft in a titanium mesh. The patient was rehabilitated with dental implants, and a good clinical outcome was achieved. We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period. In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects. Not only is this combination feasible, but it also has the advantages of lower morbidity and cost.

Bone marrow aspirate concentrate and platelet-rich fibrin in fresh extraction sockets: A histomorphometric and immunohistochemical study in humans

2020 ◽  
Author(s):  
Lucas Caldas Fontes Martins ◽  
André Luis Sousa Campos de Oliveira ◽  
Antonio Carlos Aloise ◽  
Luís Guilherme Scavone de Macedo ◽  
Marcelo Lucchesi Teixeira ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Immunohistochemical Study ◽  
Platelet Rich Fibrin ◽  
Bone Marrow Aspirate Concentrate

Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

2017 ◽  
Vol 203 (6) ◽  
pp. 339-352 ◽  
Author(s):  
Ho Youn Park ◽  
Asode Ananthram Shetty ◽  
Jang Mook Kim ◽  
Young Ju Kim ◽  
Jae-Deog Jang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Bone Defects ◽  
Control Group ◽  
Tubular Bone ◽  
Bone Marrow Aspirate Concentrate ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
New Zealand White Rabbits ◽  
Experimental Group

We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions

2017 ◽  
Vol 41 (11) ◽  
pp. 2213-2220 ◽  
Author(s):  
Mohamed A. Imam ◽  
James Holton ◽  
Lukas Ernstbrunner ◽  
Wojciech Pepke ◽  
Florian Grubhofer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Marrow ◽  
Bone Marrow Aspirate ◽  
Bone Defects ◽  
Clinical Applications ◽  
Bone Marrow Aspirate Concentrate

scholarly journals Bone marrow aspirate concentrate/platelet-rich fibrin augmentation accelerates healing of aseptic upper limb nonunions

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alessandro Mazzotta ◽  
Cesare Stagni ◽  
Martina Rocchi ◽  
Nicola Rani ◽  
Nicolandrea Del Piccolo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Upper Limb ◽  
Bone Marrow Aspirate ◽  
Healing Time ◽  
Long Bones ◽  
Platelet Rich Fibrin ◽  
Bone Marrow Aspirate Concentrate ◽  
Group A ◽  
Group B

Abstract Introduction Nonunions remain a significant burden in orthopedics, often afflicting young males of working age. Positive findings have been published using bone marrow aspirate concentrate (BMAC) and platelet-rich fibrin (PRF) for the treatment augmentation of lower limb nonunions. The aim of this study was to investigate if the treatment augmentation with BMAC and PRF can also accelerate the healing of nonunions of the upper limb. Materials and methods Sixty-eight patients (45 men, 23 women) affected by 75 nonunions of long bones of the upper limb were treated and divided into two groups. The first series was treated with standard surgery alone (group A); afterwards, the second series benefited from standard surgery with the addition of BMAC and PRF applied on lyophilized bone chips. Nonunions were classified radiographically according to the Weber–Cech method and prognostically using the Calori and Moghaddam scores. All patients were radiographically assessed at 1.5, 3, 6, 12, and 24 months of follow-up. Results Baseline demographic characteristics did not present differences between groups. No differences were documented in terms of complications (two in group A and three in group B). Significant differences were instead documented in terms of healing time. The first healing signs were observed 1.5 months after surgery in 90.7% of patients in group B and 34.4% of group A (p < 0.0005). At 1.5, 3, 6, and 12 months, a higher radiographic score was found for group B (all p < 0.0005), while no difference was found at final follow-up of 24 months (90.6% of group A and 97.7% of group B achieved radiological healing). Faster healing with BMAC/PRF augmentation was confirmed for all bones, as well as for the subgroup of patients affected by atrophic nonunions (p = 0.001). Conclusion This study showed the benefits of restoring both mechanical and biological aspects when addressing nonunions of the long bones of the upper limb. In particular, the association of BMAC and PRF to lyophilized bone chips was safe and able to accelerate healing time. These good results were confirmed for humerus, radius, and ulna sites, as well as for challenging atrophic nonunions of the upper limb.

BONE MARROW ASPIRATE CONCENTRATE INJECTION OF THE ACHILLES TENDON IN A COMPETITIVE DISTANCE RUNNER

2021 ◽  
pp. 2140004
Author(s):  
Kathryn A. Farina ◽  
Blake A. Kandah ◽  
Nan M. Sowers ◽  
Gregory A. Moore
Keyword(s):  
Bone Marrow ◽  
Achilles Tendon ◽  
Bone Marrow Aspirate ◽  
Return To Sport ◽  
Distance Runner ◽  
Complication Rates ◽  
Bone Marrow Aspirate Concentrate ◽  
Progressive Return ◽  
Competitive Athletes ◽  
Lateral Margins

Achilles tendon disorders, including tendinopathy and ruptures, are common among competitive runners. Relatively high complication rates, recurring injuries, and the need to return to sport have led to the use of regenerative medical treatment in tendon disorders in competitive athletes. Biologic therapies, including bone marrow aspirate concentrate (BMAC) injections, have been effective in restoring injured tissue in a limited number of cases. In this case, a collegiate cross country runner with Achilles tendon pain underwent years of failed, non-surgical conservative management. The patient’s MRI demonstrated moderate distal calcaneus tendinosis with high-grade partial thickness tearing of the anterior fibers of the Achilles tendon (50% tear). The patient underwent peritendinous injection of BMAC. Post-procedure MRI demonstrated minimal tendinosis of the distal and lateral margins of the Achilles tendon, and no evidence of Achilles tendon tear. The patient followed a progressive return to running program, ultimately training 40 miles per week with minimal Achilles tendon pain.

Sign in / Sign up

Export Citation Format

Share Document