scholarly journals Multimodal Imaging of Waldenstrom Macroglobulinemia-Associated Hyperviscosity-Related Retinopathy Treated with Plasmapheresis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Michael J. Schatz ◽  
Carl S. Wilkins ◽  
Oscar Otero-Marquez ◽  
Toco Y. P. Chui ◽  
Richard B. Rosen ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Outer Nuclear Layer ◽  
Analysis Software ◽  
Waldenström Macroglobulinemia ◽  
Image Analysis Software ◽  
Waldenstrom Macroglobulinemia ◽  
Retinal Capillary ◽  
Before And After ◽  
Systemic Manifestations

While plasmapheresis is well known to significantly improve both retinal findings and systemic manifestations associated with Waldenstrom macroglobulinemia, few reports exist documenting changes in optical coherence tomography angiography (OCT-A). The authors present a case of a patient with Waldenstrom macroglobulinemia who had resolution of white-centered peripheral retinal lesions and parafoveal outer nuclear layer hyperreflective material following plasmapheresis. Applying image analysis software to before and after OCT-A images, the authors were able to show an objective decrease in retinal capillary and large vessel density following plasmapheresis. This technique can be used to guide treatment and surveillance for patients with hyperviscosity-related retinopathy.

scholarly journals Anatomical Characteristics of Garcinia lucida (Vesque) and Scorodophloeus zenkeri (Harms) Wood and Debarking Response in the South Region Cameroon

2017 ◽  
Vol 6 (4) ◽  
pp. 132
Author(s):  
Marie Caroline Momo Solefack ◽  
Hans Beeckman ◽  
Lucie Felicite Temgoua ◽  
Ghislain Kenguem Kinjouo
Keyword(s):  
Image Analysis ◽  
Cross Section ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Analysis Software ◽  
Anatomical Changes ◽  
Image Analysis Software ◽  
Conductive Zone ◽  
Before And After

The aim of this work was to investigate the possible anatomical changes of Garcinia lucida and Scorodophloeus zenkeri after the removal of their bark. Debarking was done on individuals of each species at 1.30 m from the soil. The wound was rectangular in shape with 30 cm side. There was a follow-up every three months for nine months during which the survival and rate of regeneration of the bark were recorded. A block of cube was cut from the regenerated and intact wood of species for microtomy and microscopy activities. On the cross-section of each wood, vessel features like density and diameter were measured before and after wounding. Semi-automatic measurements were made using the SpectrumSee digital image analysis software. In the wood of the two species, it appeared that the density of the vessels before debarking was significantly comparable to the density after debarking, while the diameter of vessels in the regenerated wood was smaller. The cambial area increased slightly in the rainy season for all species. After nine months all the species started the restoration of their conductive zone. G. lucida heals its wound more rapidly than S. zenkeri.

scholarly journals Optical Coherence Tomography Angiography of Retinal Arterial Macroaneurysm before and after Treatment

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Victoria S. Chang ◽  
Stephen G. Schwartz ◽  
Harry W. Flynn
Keyword(s):  
Optical Coherence Tomography ◽  
Fluorescein Angiography ◽  
Multimodal Imaging ◽  
Optical Coherence Tomography Angiography ◽  
Intravitreal Bevacizumab ◽  
Optical Coherence ◽  
Flow Signal ◽  
Retinal Arterial Macroaneurysm ◽  
Diagnosis And Management ◽  
Before And After

A case of retinal arterial macroaneurysm (RAM) is presented with multimodal imaging, including commercially available optical coherence tomography angiography (OCT-A). Following treatment with intravitreal bevacizumab, reduction of flow signal through the RAM is documented. OCT-A provides useful information for the diagnosis and management of at least some patients with RAM, without the need for traditional fluorescein angiography.

Multimodal imaging of two cases of retinal vein occlusion secondary to Waldenstrom macroglobulinemia

2021 ◽  
pp. 112067212199138
Author(s):  
Lidia Remolí Sargues ◽  
Javier Montero Hernández ◽  
Catalina Navarro Palop ◽  
Clara Monferrer Adsuara ◽  
Verónica Castro Navarro ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Vein Occlusion ◽  
Multimodal Imaging ◽  
Vision Loss ◽  
Optical Coherence ◽  
Waldenström Macroglobulinemia ◽  
Vein Occlusion ◽  
Waldenstrom Macroglobulinemia ◽  
Intravitreal Dexamethasone ◽  
Intraretinal Hemorrhages

Purpose: To report multimodal imaging characteristics of two cases of retinal vein occlusion (RVO) secondary to Waldenstrom macroglobulinemia (WM). Case report: Case 1: An 82-year-old woman presented with vision loss. She had a history of WM. Best-corrected visual acuity (BCVA) was 20/100 Snellen equivalent in the right eye (OD) and 20/63 in the left eye (OS). Fundoscopy showed bilateral hemorrhages in posterior pole and along superotemporal arcade. Fluorescein angiography illustrated no macular leakage. Optical coherence tomography (OCT) revealed macular edema (ME). Optical coherence tomography angiography (OCTA) demonstrated abnormalities in choriocapillaris. A diagnosis of bilateral branch RVO was made and ME was treated with intravitreal dexamethasone, achieving stability. Case 2: A 65-year-old man presented with venous dilation, tortuosity, and intraretinal hemorrhages. BCVA was 20/20 in both eyes (OU). OCT showed ME and hyperreflective dots in choroid. A diagnosis of bilateral central RVO was made. Laboratory evaluation and bone narrow biopsy confirmed a diagnosis of WM. After that, our patient consulted because of vision loss. BCVA was 20/400 in OU. Fundoscopy and OCT demonstrated a worsening of the intraretinal hemorrhages and the ME. OCTA showed damage of choriocapillaris. Thus, intravitreal dexamethasone and plasmapheresis was advised. Two months after, BCVA was 20/40 in the OD and 20/32 in the OS. Also, fundoscopy and OCT improved. Conclusion: Early treatment of WM is truly important, with the aim of achieving a decrease in IgM levels in order to avoid toxic effect over the RPE that results in refractory ME.

scholarly journals Does intra-articular injection of adipose-derived stem cells improve cartilage mass? A case report using three-dimensional image analysis software in knee osteoarthritis

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ayano Kuwasawa ◽  
Kotaro Nihei
Keyword(s):  
Stem Cells ◽  
Image Analysis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Three Dimensional ◽  
Analysis Software ◽  
Mesenchymal Stem Cell Therapy ◽  
Dimensional Image ◽  
Image Analysis Software ◽  
Before And After

Abstract Background Mesenchymal stem cells are currently a research focus because of the possibility of cartilage regeneration through several mechanisms, including mesenchymal stem cell sheets. However, there are no published reports visualizing cartilage in three dimensions. Here, we report a case of improved cartilage volume. We purified and cultured adipose-derived mesenchymal stem cells and then performed adipose-derived mesenchymal stem cell therapy by directly injecting these cells into the articular cartilage. Cartilage was quantitatively evaluated before and after injection using three-dimensional image analysis software based on the magnetic resonance imaging. Case presentation The patient, a 55-year-old Japanese woman, experienced pain in both knees and was diagnosed with osteoarthritis of the knee. We performed adipose-derived mesenchymal stem cell therapy in both knees at our hospital and quantitatively evaluated cartilage before and after the treatment using the three-dimensional image analysis software “SYNAPSE VINCENT”. Conclusions Preoperatively, the cartilage defect area was 33.59 mm2 in the femur and 122.31 mm2 in the tibia; however, 12 months postoperatively, it improved to 13.59 mm2 and 51.43 mm2, respectively. Furthermore, the preoperative femur and tibia volumes were 9.58 mL and 3.82 mL, respectively; however, 12 months postoperatively, these values improved to 10.00 mL and 4.17 mL, respectively. For the quantitative analysis of cartilage, SYNAPSE VINCENT visualizes the state of cartilage in a high-definition three-dimensional image, which is excellent for understanding the state of the disease and explaining it to the patient. Although SYNAPSE VINCENT can only analyze the thickness of cartilage, and the reproducibility of the error is debatable, SYNAPSE VINCENT would be useful as a clinical tool for regenerative medicine. We have shown in this case report the promising effects of adipose-derived stem cell intraarticular injections in treating osteoarthritis and the use of new diagnostic instruments.

scholarly journals Does intra-articular injection of adipose-derived stem cells improve cartilage mass? A case report on a 3D MRI quantitative evaluation of cartilage in knee osteoarthritis using SYNAPSE VINCENT: a case report

2020 ◽  
Author(s):  
Ayano Kuwasawa ◽  
Kotaro Nihei
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Image Analysis ◽  
Case Report ◽  
The State ◽  
3D Image ◽  
Analysis Software ◽  
3D Image Analysis ◽  
Image Analysis Software ◽  
Before And After

Abstract Background: Mesenchymal stem cells (MSC) are currently in focus because of the possibility of cartilage regeneration through several ways, including MSC sheets. However, there is no published report that visualizes cartilage in three dimensions. Here, we report a case of improved cartilage volume. We purified and cultured adipose-derived mesenchymal stem cells (ASC) and then performed ASC therapy by directly injecting these cells into the articular cartilage. Cartilage was quantitatively evaluated before and after injection using a three-dimensional (3D) image analysis software based on the MRI imagery.Case presentation: The patient, a 55-year-old woman, experienced pain in both knees and was diagnosed with osteoarthritis of the knee. We performed ASC therapy in both knees at our hospital and quantitatively evaluated cartilage before and after the treatment using the 3D image analysis software “SYNAPSE VINCENT”.Conclusions: For the quantitative analysis of cartilage, SYNAPSE VINCENT visualizes the state of cartilage in a high-definition 3D image, which is excellent for understanding the state of the disease and explaining it to the patient. Though there is room for debate about the reproducibility of errors, etc., SYNAPSE VINCENT would be useful as a clinical tool for regenerative medicine.

scholarly journals Does intra-articular injection of adipose-derived stem cells improve cartilage mass? A case report on a 3D MRI quantitative evaluation of cartilage in knee osteoarthritis using SYNAPSE VINCENT: a case report

2020 ◽  
Author(s):  
Ayano Kuwasawa ◽  
Kotaro Nihei
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Image Analysis ◽  
Case Report ◽  
The State ◽  
3D Image ◽  
Analysis Software ◽  
3D Image Analysis ◽  
Image Analysis Software ◽  
Before And After

Abstract Background: Mesenchymal stem cells (MSC) are currently in focus because of the possibility of cartilage regeneration through several ways, including MSC sheets. However, there is no published report that visualizes cartilage in three dimensions. Here, we report a case of improved cartilage volume. We purified and cultured adipose-derived mesenchymal stem cells (ASC) and then performed ASC therapy by directly injecting these cells into the articular cartilage. Cartilage was quantitatively evaluated before and after injection using a three-dimensional (3D) image analysis software based on the MRI imagery.Case presentation: The patient, a 55-year-old woman, experienced pain in both knees and was diagnosed with osteoarthritis of the knee. We performed ASC therapy in both knees at our hospital and quantitatively evaluated cartilage before and after the treatment using the 3D image analysis software “SYNAPSE VINCENT”.Conclusions: For the quantitative analysis of cartilage, SYNAPSE VINCENT visualizes the state of cartilage in a high-definition 3D image, which is excellent for understanding the state of the disease and explaining it to the patient. Though there is room for debate about the reproducibility of errors, etc., SYNAPSE VINCENT would be useful as a clinical tool for regenerative medicine.

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