scholarly journals Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Enji Ahmed ◽  
Olfat G. Shaker ◽  
Nermin Yussif ◽  
Dalia M. Ghalwash
Keyword(s):  
Clinical Trial ◽  
Periodontal Therapy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
Nonsurgical Periodontal Therapy ◽  
Grade Ii ◽  
Nonsurgical Therapy ◽  
Anti Inflammatory

Objectives. Periodontitis is characterized by inflammatory destruction of periodontal tissue, loss of attachment, and bone resorption. The increase in reactive oxygen species (ROS) is responsible for the oxidative damage occurring in periodontal tissues. Melatonin has important immunomodulatory, anti-inflammatory, and powerful antioxidant functions. The current study was carried out to evaluate the effect of topical melatonin gel as an adjunct to nonsurgical periodontal therapy. Methods. This split-mouth randomized controlled clinical trial was performed on 24 patients with grade II periodontitis. Two sites in each patient were randomly assigned; test sites were treated by nonsurgical therapy followed by intrapocket application of 5% melatonin gel. Control sites were treated by nonsurgical therapy followed by intrapocket application of placebo gel. Both the melatonin and placebo gel were applied weekly once for four weeks. Assessment of clinical parameters (PD and CAL) was done at baseline and 3 months after therapy. Total antioxidative capacity (TAC) and matrix metalloproteinase-9 (MMP-9) levels in GCF were also evaluated utilizing commercially available enzyme-linked immunosorbent assay kits (ELISA) at baseline and 3 months after therapy. Results. Treatment with topical melatonin was associated with a reduction in periodontal inflammation reflected as an improvement in the clinical periodontal parameters. Melatonin-treated sites showed a more statistically significant percent reduction in PD and more statistically significant percent gain in CAL than the control site. Additionally, a significant increase in TAC and a significant decrease in MMP-9 levels in GCF were found in melatonin-treated sites in comparison to control sites. Conclusions. The adjunctive use of topical melatonin gel with nonsurgical periodontal therapy has potent anti-inflammatory and antioxidant activity in the treatment of grade II periodontitis patients.

scholarly journals Diode Laser as an Adjunctive to Nonsurgical Periodontal Therapy during Maintenance Phase: A Randomized Controlled Clinical Trial

2016 ◽  
Vol 6 (1) ◽  
pp. 12-17
Author(s):  
SS Suprith ◽  
Swati Setty ◽  
Srinath Thakur
Keyword(s):  
Clinical Trial ◽  
Diode Laser ◽  
Maintenance Phase ◽  
Periodontal Therapy ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Attachment Loss ◽  
Randomized Controlled ◽  
Group I ◽  
Nonsurgical Periodontal Therapy

ABSTRACT Aim The aim of the study was to determine and compare the pocket depths (PD), relative attachment levels (RAL), bleeding on probing (BOP) and plaque indices (PI) in patients treated with scaling and root planning (SRP) alone and along with diode laser. Materials and methods The study was carried out on 30 subjects who fulfill the inclusion and exclusion criteria. Group I: 15 patients treated with SRP along with diode laser irradiation. Group II: 15 patients treated only with SRP. The clinical parameters were probing PD, RAL, BOP and PI which were recorded at base line, 7 days and after 1 month. Statistical analysis was done using Kolmogorov-Smirnov, Shapiro-Wilk, t-test, chi-square test. Results The use of diode lasers as an adjunct to SRP during maintenance phase showed better results when compared to SRP alone. Moderate periodontal pockets with moderate attachment loss showed significant improvement in group I than in group II. There was no change in deep pockets with severe attachment loss in both groups. Clinical significance The study shows that the specified laser parameter and the modality of application of the same results in faster healing. This can be recommended as an appropriate treatment for moderate pockets. How to cite this article Suprit SS, Setty S, Thakur S. Diode Laser as an Adjunctive to Nonsurgical Periodontal Therapy during Maintenance Phase: A Randomized Controlled Clinical Trial. Int J Laser Dent 2016;6(1):12-17.

scholarly journals Comparison between 940 nm Laser Diode and Topical 5 % Potassium Nitrate for Tooth Desensitization. Randomized Controlled Clinical trial

2018 ◽  
Vol 37 (79) ◽  
Author(s):  
Oscar Tocarruncho ◽  
Xiomara Alexandra Espitia Robayo ◽  
Edgar Ibáñez Pinilla ◽  
Néstor Raúl Ríos-Osorio
Keyword(s):  
Clinical Trial ◽  
Laser Diode ◽  
Therapy Group ◽  
Potassium Nitrate ◽  
Periodontal Therapy ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Randomized Controlled ◽  
Actual Application ◽  
Higher Sensitivity

Purpose: To compare the effectiveness of two dental desensitization therapies, 940 nm laser diode and potassium nitrate, in patients with dental hypersensitivity (DH) symptoms. Methods: This randomized clinical trial included 30 patients who initially underwent basic periodontal therapy and presented gingival recessions Class I and II (Miller 1985) with symptoms of DH. Subjects were randomly assigned into two groups. The first group (n = 15) received laser 940 nm application for 90 seconds on the surface of the recession and were given a tube of glycerin to be applied daily in order to avoid generating bias. Patients in the second group (n = 15) were exposed to inactive laser simulating the actual application of the laser, and they were given a desensitizing gel containing 0.5 g of potassium nitrate to be applied twice daily during 14 days. Controls were carried out at 15 minutes, 8 days, 15 days, and 4 weeks. Data obtained were filled out in an Excel table. For comparison between groups the Mann Whitney U and t student tests were used (p=0.05). Results: All patients involve in the study experienced reduction in DH (p<0.01) and differences   between the two interventions performed. Conclusions:  Laser and nitrate therapies were effective to manage DH after basic periodontal therapy. However, a statistically significant higher  sensitivity reduction was observed in laser therapy group.

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