Effects of GV14 Acupuncture on Cerebral Blood Flow Velocity in the Basilar and Middle Cerebral Arteries and CO2 Reactivity during Hypercapnia in Normal Individuals

The Governing Vessel 14 (GV14) (Dazhui) is one of the acupuncture points referred to as “seven acupoints for stroke.” Nevertheless, there is a scarcity of research on the effects of acupuncture treatment at GV14. This study investigated the effects of acupuncture at GV14 on cerebral blood flow (CBF), especially that in the basilar artery (BA) and the middle cerebral arteries (MCA). Sixteen healthy men aged 20 to 29 years were enrolled in this study. CBF velocity and cerebrovascular reactivity (CVR) were measured using transcranial Doppler sonography (TCD). The following were assessed: closed circuit rebreathing- (CCR-) induced carbon dioxide (CO2) reactivity, modified blood flow velocity at 40 mmHg (CV40) on BA and MCAs, blood pressure (BP), and heart rate (HR). Observed results were obtained after comparison with the baseline evaluation. Statistically significant elevations in CO2 reactivity were recorded in the BA (3.28 to 4.70, p < 0.001 ) and MCAs (right: 3.81 to 5.25, p = 0.001 ; left: 3.84 to 5.12, p = 0.005 ) after acupuncture at GV14. The CV40 increased statistically significantly only in the BA (45.49 to 50.41, p = 0.003 ). No change was observed in BP (106.83 to 107.08 (mmHg), p = 0.335 ) and HR (77 to 75 (bpm), p = 0.431 ). Acupuncture at GV14 improved CBF velocity. These results could be explained by the regulation of endothelium-dependent vessel dilation effected by acupuncture. This trial is registered with Korean Clinical Trial Registry (http://cris.nih.go.kr; registration number: KCT0004787).

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Effects of LI11 Acupuncture on CO2 reactivity in the anterior and middle cerebral arteries during hyperventilation-induced hypocapnia in normal subjects: A before and after study

Journal of Korean Medicine ◽

10.13048/jkm.21044 ◽

2021 ◽

Vol 42 (4) ◽

pp. 174-185

Author(s):

Gyeong-muk Kim ◽

Woo-Sang Jung ◽

Seungwon Kwon ◽

Chul Jin ◽

Seung-Yeon Cho ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Flow Velocity ◽

Cerebral Artery ◽

Blood Flow Velocity ◽

Cerebral Blood Flow Velocity ◽

Cerebral Arteries ◽

Co2 Reactivity ◽

Middle Cerebral Arteries ◽

Before And After

Objectives: The LI11 (Quchi) acupuncture point has always been included in the Seven acupoints for stroke; however, additional LI11 acupuncture research is needed. In this study, the effect of LI11 acupuncture on cerebral blood flow of the anterior cerebral arteries (ACA) and middle cerebral arteries (MCA) was investigated.Method: This study included 10 healthy young male subjects. Cerebral blood flow velocity and cerebrovascular reactivity were measured using transcranial Doppler sonography. Changes in hyperventilation-induced carbon dioxide (CO2) reactivity and modified ACA and MCA blood flow velocity at 40 mmHg (CV40), blood pressure, and heart rate were observed before and after LI11 acupuncture treatment.Results: A statistically significant increase in contralateral anterior cerebral artery CO2 reactivity (p=0.036) and decrease in contralateral middle cerebral artery CV40 (p=0.047) were observed. No significant difference in mean blood pressure was shown. A statistically significant increase in heart rate occurred after LI11 acupuncture; however, it was not clinically significant as there were negligible changes in the heart rhythm.Conclusions: LI11 acupuncture treatment could improve cerebral blood flow velocity. These results might be explained by regulating endothelium-dependent vessel dilation in the anterior cerebral artery region.Trial registration: This trial has been registered with Clinical Research Information Service, a service of the Korea Centers for Disease Control and Prevention: KCT0004494 (retrospectively registered). https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=15359

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Cerebral lateralisation for facial processing: Gender-related cognitive styles determined using Fourier analysis of mean cerebral blood flow velocity in the middle cerebral arteries

Laterality Asymmetries of Body Brain and Cognition ◽

10.1080/13576500600886796 ◽

2007 ◽

Vol 12 (1) ◽

pp. 31-49 ◽

Cited By ~ 13

Author(s):

Philip C. Njemanze

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Fourier Analysis ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Cerebral Blood Flow Velocity ◽

Cerebral Arteries ◽

Cognitive Styles ◽

Facial Processing ◽

Middle Cerebral Arteries

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Spontaneous oscillations of cerebral blood flow velocity in the middle cerebral arteries of normal subjects and schizophrenic patients

Psychiatry Research Neuroimaging ◽

10.1016/s0925-4927(99)00039-6 ◽

1999 ◽

Vol 92 (2-3) ◽

pp. 93-102 ◽

Cited By ~ 6

Author(s):

Shin-Min Lee ◽

Ping-Keung Yip ◽

Jiann-Shing Jeng ◽

Hsing-Jon Lo ◽

Ming Chang

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Cerebral Blood Flow Velocity ◽

Cerebral Arteries ◽

Normal Subjects ◽

Middle Cerebral Arteries ◽

Schizophrenic Patients ◽

Spontaneous Oscillations

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Regional Differences in the Cerebral Blood Flow Velocity Response to Hypobaric Hypoxia at High Altitudes

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/jcbfm.2015.142 ◽

2015 ◽

Vol 35 (11) ◽

pp. 1846-1851 ◽

Cited By ~ 16

Author(s):

Berend Feddersen ◽

Pritam Neupane ◽

Florian Thanbichler ◽

Irmgard Hadolt ◽

Vera Sattelmeyer ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Hypobaric Hypoxia ◽

Cerebral Blood Flow Velocity ◽

Cerebral Arteries ◽

Acute Mountain Sickness ◽

Transcranial Doppler Sonography ◽

Beta Activity

Symptoms of acute mountain sickness (AMS) may appear above 2,500 m altitude, if the time allowed for acclimatization is insufficient. As the mechanisms underlying brain adaptation to the hypobaric hypoxic environment are not fully understood, a prospective study was performed investigating neurophysiological changes by means of near infrared spectroscopy, electroencephalograpy (EEG), and transcranial doppler sonography at 100, 3,440 and 5,050 m above sea level in the Khumbu Himal, Nepal. Fourteen of the 26 mountaineers reaching 5,050 m altitude developed symptoms of AMS between 3,440 and 5,050 m altitude (Lake-Louise Score ≥ 3). Their EEG frontal beta activity and occipital alpha activity increased between 100 and 3,440 m altitude, i.e., before symptoms appeared. Cerebral blood flow velocity (CBFV) in the anterior and middle cerebral arteries (MCAs) increased in all mountaineers between 100 and 3,440 m altitude. During further ascent to 5,050 m altitude, mountaineers with AMS developed a further increase in CBFV in the MCA, whereas in all mountaineers CBFV decreased continuously with increasing altitude in the posterior cerebral arteries. These results indicate that hypobaric hypoxia causes different regional changes in CBFV despite similar electrophysiological changes.

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Transcranial Doppler Evaluation of the Cerebral Vasculature in Women Patients who Have Migraine with Aura

Pain Medicine ◽

10.1093/pm/pnaa292 ◽

2020 ◽

Vol 21 (11) ◽

pp. 3012-3017

Author(s):

Igor Petrušić ◽

Ana Podgorac ◽

Aleksandra Radojičić ◽

Jasna Zidverc-Trajković

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Migraine With Aura ◽

Transcranial Doppler ◽

Cerebral Blood Flow Velocity ◽

Cerebral Arteries ◽

Transcranial Doppler Sonography ◽

Cerebrovascular Reactivity ◽

Breath Holding ◽

Left And Right

Abstract Background Previous studies suggest that increased cerebrovascular reactivity might be a feature of patients who have migraine with aura (MwA). The correlation between the clinical presentation of migraine with aura and transcranial Doppler parameters remains unclear. Objective The main aim of this study was to explore cerebral blood flow, vascular resistance, and cerebrovascular reactivity in women MwA. Also, the relationships between hemodynamic conditions and aura characteristics are examined. Design Cross-sectional study. Setting Headache Center, Neurology Clinic, Clinical Center of Serbia. Subjects Fifty-four women MwA and 49 healthy controls (HCs). Methods Transcranial Doppler sonography examination was used to determine blood flow mean velocity (MV) and pulsatility index (PI), as well as breath-holding index (BHI), in 15 arterial segments comprising the circle of Willis. Results A total of 54 women MwA and 49 HCs were studied. The PIs of all segments of the left and right middle cerebral arteries and the left and right anterior cerebral arteries were significantly higher in MwA with regards to HCs. Also, both the left and right BHIs were significantly higher in MwA than HCs. In addition, MVs of the right vertebral artery and the first segment of the basilar artery were significantly lower in MwA than HCs. Longer duration of migraine aura showed a weak negative correlation with the PI of the left posterior cerebral artery. Conclusions Our findings suggest increased vessel pulsatility, abnormal cerebrovascular reactivity, and decreased cerebral blood flow velocity in several arterial segments of the Willis circle in women MwA.

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