Bacteremia in a Newborn with Hypocalcemic Seizures and Vitamin D Deficiency

Infants with neonatal hypocalcemia often present with seizures, and neonatal hypocalcemia can be due to parathyroid (PTH) insufficiency or resistance. Causes of hypocalcemia with PTH elevation include increased phosphate load, vitamin D deficiency (VDD) or defects in metabolism, renal dysfunction, hypomagnesemia, genetic mutations resulting in end-organ resistance to PTH, or critical illness. Hypocalcemia has also been shown to be associated with Gram-negative bacteremia and sepsis in adults. We present the case of a full-term, formula-fed newborn presenting with late-onset hypocalcemic seizures and VDD in the setting of Klebsiella pneumoniae bacteremia. This case highlights that newborns presenting with hypocalcemic seizures should undergo a workup for sepsis.

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Late-Onset Neonatal Hypocalcemia in a 9-Days-Old Baby Because of Vitamin D Deficiency and Hypoparathyroidism: A Case Report

Bali Medical Journal ◽

10.15562/bmj.v5i3.355 ◽

2016 ◽

Vol 5 (3) ◽

pp. 208

Author(s):

I Made Arimbawa ◽

Dwiyathi Utami ◽

I Wayan Bikin Suryawan

Keyword(s):

Vitamin D ◽

Case Report ◽

Vitamin D Deficiency ◽

Late Onset ◽

Neonatal Hypocalcemia

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Late-Onset Neonatal Hypocalcemia Due to High Dietary Phosphorus Load in the Setting of Profound Vitamin D Deficiency: Should High-Risk Mothers Be Screened?

10.1210/endo-meetings.2011.part2.p26.p2-128 ◽

2011 ◽

pp. P2-128-P2-128

Author(s):

Noelle S Larson ◽

Karen S Vogt

Keyword(s):

Vitamin D ◽

High Risk ◽

Vitamin D Deficiency ◽

Late Onset ◽

Phosphorus Load ◽

Dietary Phosphorus ◽

Neonatal Hypocalcemia

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Etiology and resistance patterns of bacteria causing ventilator-associated pneumonia in a respiratory intensive care unit

Vojnosanitetski pregled ◽

10.2298/vsp151216270i ◽

2017 ◽

Vol 74 (10) ◽

pp. 954-962 ◽

Cited By ~ 2

Author(s):

Vlada Injac ◽

Uros Batranovic ◽

Jovan Matijasevic ◽

Marija Vukoja ◽

Mirjana Hadnadjev ◽

...

Keyword(s):

Intensive Care ◽

Klebsiella Pneumoniae ◽

Early Onset ◽

Late Onset ◽

Resistance Rate ◽

Ventilator Associated Pneumonia ◽

Gram Negative ◽

Resistance Patterns ◽

Acinetobacter Spp ◽

Gram Negative Organisms

Background/Aim. Ventilator-associated pneumonia (VAP) incidence, causative pathogens, and resistance patterns are different among countries and intensive care units (ICUs). In Europe, resistant organisms have progressively increased in the last decade. However, there is a lack of data from Serbian ICUs. The aims of this study were to evaluate etiology and antimicrobial resistance for pathogens causing VAP in ICU patients, to examine whether there were differences among pathogens in early-onset and late-onset VAP and to identify mortality in patients with VAP after 30 and 60 days of hospitalization. Methods. A retrospective cohort study was conducted in the respiratory ICU and all adult patients diagnosed with VAP from 2009 to 2014 were included. Results. Gram negative organisms were the major pathogens (80.3%). The most commonly isolated was Acinetobacter spp (59.8%). There was a statistically significant increase in the incidence of infection with Klebsiella pneumoniae (8.9% vs 25.6%; p = 0.019). Extensively drugresistant strains (XDR) were the most common (78.7%). Lateonset VAP was developed in 81.1% of patients without differences among pathogens in comparison with early-onset VAP. Acinetobacter spp was susceptible to tigecycline and colistin with a significant increase in resistance to ampicillin/sulbactam (30.2% vs 58.6%; p = 0.01). Resistance rate of Pseudomonas aeruginosa and Klebsiella pneumoniae to carbapenems was 38% and 11%, respectively. In methicillin-resistant Staphylococcus aureus no resistance was observed against vancomycin and linezolid. There was no difference in mortality rate between patients with earlyonset and late-onset VAP after 30 and 60 days of hospitalization. Conclusion. Gram negative organisms were the primary cause of bacterial VAP of which the most common was the XDR strain of Acinetobacter spp. Patients with early- and late-onset VAP had the same pathogens. There was no difference in mortality between this two group of patients during 60 days of hospitalization.

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