scholarly journals Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Shan Tu ◽  
Zhi-Jie Shen ◽  
Xiao-Yan Wang ◽  
Li-Xiong Zeng ◽  
Zhi-Hui Zhang
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Sham Group ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Control Group ◽  
Renal Sympathetic

This study explored the effects of renal sympathetic denervation (RDN) on hyperlipidity-induced cardiac hypertrophy in beagle dogs. Sixty beagles were randomly assigned to the control group, RDN group, or sham-operated group. The control group was fed with a basal diet, while the other two groups were given a high-fat diet to induce model hypertension. The RDN group underwent an RDN procedure, and the sham-operated group underwent only renal arteriography. At 1, 3, and 6 months after the RDN procedure, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) levels were markedly decreased in the RDN group relative to the sham group ( P < 0.05 ). After 6 months, serum norepinephrine (NE) and angiotensin II (AngII), as well as left ventricular levels, in the RDN group were statistically lower than those in the sham group ( P < 0.05 ). Also, the left ventricular mass (LVM) and left ventricular mass index (LVMI) were significantly decreased, while the E/A peak ratio was drastically elevated ( P < 0.05 ). Pathological examination showed that the degree of left ventricular hypertrophy and fibrosis in the RDN group was statistically decreased relative to those of the sham group and that the collagen volume fraction (CVF) and perivascular circumferential collagen area (PVCA) were also significantly reduced ( P < 0.05 ). Renal sympathetic denervation not only effectively reduced blood pressure levels in hypertensive dogs but also reduced left ventricular hypertrophy and myocardial fibrosis and improved left ventricular diastolic function. The underlying mechanisms may involve a reduction of NE and AngII levels in the circulation and myocardial tissues, which would lead to the delayed occurrence of left ventricular remodeling.

Effects of renal sympathetic denervation in left ventricular hypertrophy in CKD refractory hypertensive patients

2016 ◽  
Vol 202 ◽  
pp. 121-123 ◽  
Author(s):  
Márcio Galindo Kiuchi ◽  
Miguel Luis Graciano ◽  
Maria Angela Magalhães de Queiroz Carreira ◽  
Tetsuaki Kiuchi ◽  
Shaojie Chen ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Hypertensive Patients ◽  
Renal Sympathetic

scholarly journals Effects of Renal Sympathetic Denervation in Diastolic Heart Function in CKD Refractory Hypertensive Patients

2016 ◽  
Vol 1 ◽  
Author(s):  
Márcio Galindo Kiuchi ◽  
Miguel Luis Graciano ◽  
Maria Angela Magalhães de Queiroz Carrei ◽  
Tetsuaki Kiuchi ◽  
Jocemir Ronaldo Lugon
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Heart Function ◽  
Diastolic Heart Failure ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Early Assessment ◽  
Renal Sympathetic

<p>Diastolic heart failure (HF) is an important factor that increases mortality related to the cardiovascular system in patients with chronic kidney disease (CKD) whose extent of kidney function deterioration differs. As a non-invasive method to allow early assessment, the E/e’ ratio estimated by tissue Doppler imaging can predict mortality and cardiovascular events in CKD patients with diastolic dysfunction. The current study evaluated 15 patients with CKD and left ventricular hypertrophy (LVH), who were selected according to a previously published protocol. In the present study, we reported for the first time the improvement in diastolic parameters measured by echocardiography in CKD patients with resistant hypertension and left ventricular hypertrophy 6 months after renal sympathetic denervation (RSD). Our results suggest that RSD in this kind of patients seems to avoid the progression to diastolic HF.</p>

EVALUATION OF LEFT VENTRICULAR MASS IN THE PREHYPERTENSIVES BY ELECTROCARDIOGRAPHY AND ECHOCARDIOGRAPHY

2011 ◽  
pp. 119-125
Author(s):  
Thi Thuy Hang Nguyen
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Structural Changes ◽  
Left Ventricular ◽  
Control Group ◽  
Concentric Left Ventricular Hypertrophy ◽  
Increased Risk ◽  
Lv Mass ◽  
Left Ventricular Morphology

Objective: Prehypertensive individuals are at increased risk for developing hypertension and their complication. Many studies show that 2/3 prehypertensive individuals develop hypertension after 4 years. ECG and echocardiography are the routine tests used to assess LV mass. The objective of the research to determine the percentage of change in left ventricular morphology in the ECG, echocardiography, which explore the characteristics of left ventricular structural changes by echocardiography in pre-hypertensive subjects. Materials and method: We studied a total of 50 prehypertensive, 30 males (60%) and 20 females (40%), mean age 48.20±8.47years. 50 normotensive volunteers as control participants. These subjects were examined for ECG and echocardiography. Results: In prehypertensive group, with 18% of left ventricular hypertrophy on electrocardiogram, 12% of left ventricular hypertrophy on echocardiography; in the control group, we did not find any subjects with left ventricular hypertrophy. In the group with left ventricular hypertrophy, mostly eccentric left ventricular hypertrophy (83.33%), concentric left ventricular hypertrophy is 16.67%. Restructuring of left ventricular concentric for 15.9% of subjects without left ventricular hypertrophy on echocardiography. Conclusion: There have been changed in left ventricular morphology even in prehypertensive

scholarly journals Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats

2017 ◽  
Vol 122 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Peng Li ◽  
Pei-Pei Huang ◽  
Yun Yang ◽  
Chi Liu ◽  
Yan Lu ◽  
...  
Keyword(s):  
Rat Model ◽  
Vascular Remodeling ◽  
Sympathetic Activity ◽  
Sham Group ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Plasma Norepinephrine ◽  
Sham Surgery ◽  
Renal Sympathetic

Li P, Huang P, Yang Y, Liu C, Lu Y, Wang F, Sun W, Kong X. Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. J Appl Physiol 122: 121–129, 2017. First published October 14, 2016; doi: 10.1152/japplphysiol.01019.2015 .—Sympathetic activity is enhanced in patients with essential or secondary hypertension, as well as in various hypertensive animal models. Therapeutic targeting of sympathetic activation is considered an effective antihypertensive strategy. We hypothesized that renal sympathetic denervation (RSD) attenuates hypertension and improves vascular remodeling and renal disease in the 2-kidney, 1-clip (2K1C) rat model. Rats underwent 2K1C modeling or sham surgery; then rats underwent RSD or sham surgery 4 wk later, thus resulting in four groups (normotensive-sham, normotensive-RSD, 2K1C-sham, and 2K1C-RSD). Norepinephrine was measured by ELISA. Echocardiography was used to assess heart function. Fibrosis and apoptosis were assessed by Masson and TUNEL staining. Changes in mean arterial blood pressure in response to hexamethonium and plasma norepinephrine levels were used to evaluate basal sympathetic nerve activity. The 2K1C modeling success rate was 86.8%. RSD reversed the elevated systolic blood pressure induced by 2K1C, but had no effect on body weight. Compared with rats in the 2K1C-sham group, rats in the 2K1C-RSD group showed lower left ventricular mass/body weight ratio, interventricular septal thickness in diastole, left ventricular end-systolic diameter, and left ventricular posterior wall thickness in systole, whereas fractional shortening and ejection fraction were higher. Right kidney apoptosis and left kidney hypertrophy were not changed by RSD. Arterial fibrosis was lower in animals in the 2K1C-RSD group compared with those in the 2K1C-sham group. RSD reduced plasma norepinephrine and basal sympathetic activity in rats in the 2K1C-RSD group compared with rats in the 2K1C-sham group. These results suggest a possible clinical efficacy of RSD for renovascular hypertension. NEW & NOTEWORTHY The effects of renal sympathetic denervation (RSD) on hypertension, cardiac function, vascular fibrosis, and renal apoptosis were studied in the 2K1C rat model. Results showed that RSD attenuated hypertension, improved vascular remodeling, and reduced vascular fibrosis through decreased sympathetic activity in the 2K1C rat model, but it did not change the kidney size, renal apoptosis, or renal caspase-3 expression. These results could suggest possible clinical efficacy of RSD for renovascular hypertension.

scholarly journals KORELASI ANTARA TEKANAN DARAH DAN INDEKS MASSA VENTRIKEL KIRI (LEFT VENTRICULAR MASS INDEX) PADA PENDERITA HIPERTENSI DI RSUP PROF. DR. R. D. KANDOU MANADO

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Asdiana Nur ◽  
Fransiska Lintong ◽  
Maya Moningka
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular Mass Index ◽  
Pressure Control ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Consecutive Sampling ◽  
Ventricular Mass

Abstract: Left ventricular hypertrophy (LVH) is target organ damage of cardiac with high prevalence in patients with hypertension. Increase of left ventricular mass was caused by increase in wall thickness as compensatory mechanism to minimize wall stress in response to elevated blood pressure. Left Ventricular Mass Index (LVMI) is one of echocardiography parameters used to diagnose LVH. The purpose of this study is to know the correlation between blood pressure and LVMI in patients with hypertension. A cross sectional study was performed at Cardiac Vascular and Brain Centre/ Central General Hospital of Prof. Dr. R. D Kandou. Sample was determined with consecutive sampling. Blood pressure of subjects were measurement and LVMI were taken from medical record. Data were analyzed used SPSS 21. Fifty one subjects, including 34 subjects with adequate blood pressure control and 17 subjects with inadequate blood pressure control are enrolled with ≥60 years old and men (64.7%) mostly found in this study. Pearson Correlation Test found a positive and significant correlation between systolic blood pressure and LVMI (r=0.488;p<0.05) while Spearman Correlation Test found a positive but not significant correlation between diastolic blood pressure and LVMI (r=0.226;p>0.05). In conclusion, there is a positive correlation between blood pressure and LVMI in patients with hypertension but a significant correlation was just found between systolic blood pressure and LVMI.Keywords: hypertension, Left ventricular hypertrophy (LVH), blood pressure, echocardiography, left ventricular mass index (LVMI)Abstrak: Hipertrofi ventrikel kiri (Left Ventricular Hypertrophy= LVH) merupakan kerusakan target organ jantung dengan prevalensi yang tinggi pada penderita hipertensi. Peningkatan massa ventrikel kiri disebabkan oleh penebalan dinding ventrikel kiri sebagai mekanisme kompensasi untuk meminimalkan tegangan dinding akibat respon terhadap peningkatan tekanan darah. Indeks massa ventrikel kiri (Left Ventricular Mass Index= LVMI) merupakan salah satu parameter ekokardiografi yang digunakan dalam mendiagnosa LVH. Tujuan dari penelitian ini adalah mengetahui korelasi antara tekanan darah dan LVMI pada penderita hipertensi. Penelitian dengan desain potong lintang dilakukan di instalasi pusat jantung dan pembuluh darah RSUP Prof Dr. R. D. Kandou. Sampel ditentukan secara consecutive sampling. Pengukuran tekanan darah dilakukan pada subyek penelitian dan LVMI diperoleh dari rekam medik. Data dianalisa menggunakan SPSS 21. Sebanyak 51 subyek penelitian, termasuk 34 subyek dengan hipertensi terkontrol dan 17 subyek dengan hipertensi tidak terkontrol, terdaftar pada penelitian ini dengan usia ≥60 tahun (39,2%) dan pria (64,7%)paling banyak ditemukan.Uji Korelasi Pearson menemukan tekanan darah sistolik mempunyai korelasi positif dan signifikan dengan LVMI (r=0,488;p<0,05) sedangkan uji Korelasi Spearman menemukan korelasi yang positif namun tidak signifikan antara tekanan darah diastolik dan LVMI (r=0,226;p>0,05). kesimpulan dari penelitian ini adalah terdapat korelasi positif antara tekanan darah dan LVMI pada penderita hipertensi, namun hubungan yang signifikan hanya ditemukan antara tekanan darah sistolik dan LVMI.Kata Kunci : hipertensi, hipertrofi ventrikel kiri, tekanan darah, ekokardiografi, indeks massa ventrikel kiri

Effects of Twice-Daily Icodextrin Administration on Blood Pressure and Left Ventricular Mass in Patients on Continuous Ambulatory Peritoneal Dialysis

2009 ◽  
Vol 29 (4) ◽  
pp. 443-449 ◽  
Author(s):  
Tansu Sav ◽  
Oktay Oymak ◽  
Mehmet Tugrul Inanc ◽  
Ali Dogan ◽  
Bulent Tokgoz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Peritoneal Dialysis ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Dialysis Patients ◽  
Once Daily ◽  
The Third ◽  
Ultrafiltration Failure

Background Hypervolemia is a risk factor for left ventricular hypertrophy and hypertension in peritoneal dialysis patients. Icodextrin improves volume control by increasing ultrafiltration in peritoneal dialysis patients. Aim To examine the effects of twice-daily icodextrin administration on blood pressure and left ventricular hypertrophy in peritoneal dialysis patients with hypervolemia and ultrafiltration failure. Method and Results Administration of icodextrin twice daily resulted in a significant reduction in the left ventricular mass index (LVMI) of patients by the end of the third month ( p < 0.05). The reduction in LVMI was also significant for the once-daily icodextrin group ( p < 0.05). Mean blood pressure of patients receiving icodextrin twice daily was significantly reduced ( p < 0.05). By the end of the third month no significant changes were observed in mean blood pressure of the patients using once-daily icodextrin ( p > 0.05). No statistically significant changes were observed in weekly total creatinine clearances or Kt/V of patients in either group at the end of 3 months (NS). Conclusion Twice-daily icodextrin administration was clinically beneficial as shown by reduced blood pressure and prevention of the progress of left ventricular hypertrophy without causing any decrease in dialysis adequacy or any side effects. The icodextrin metabolite results did not suggest any further increase in their values when comparing once- to twice-daily administration of icodextrin. Although prescription of icodextrin once daily may yield good clinical results in the long term, this study showed that it may be more efficient to use twice-daily icodextrin for at least a specific period for the purpose of obtaining quicker results in patients with ultrafiltration failure, serious hypervolemia, or hard-to-control blood pressure conditions.

Left ventricular hypertrophy: reduction of blood pressure already in the normal range further regresses left ventricular mass

Heart ◽  
2009 ◽  
Vol 96 (2) ◽  
pp. 148-152 ◽  
Author(s):  
H J Simpson ◽  
S J Gandy ◽  
J G Houston ◽  
N S Rajendra ◽  
J I Davies ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Normal Range ◽  
Ventricular Mass
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