scholarly journals A Matter of Time: Delayed Presentation and Rapid Progression from Gonadotropin-Independent to Gonadotropin-Dependent Precocious Puberty following Successful Treatment for a Leydig Cell Tumor

2022 ◽  
Vol 2022 ◽  
pp. 1-4
Author(s):  
C. R. Naotunna ◽  
D. N. Siriwardana ◽  
B. C. Lakmini ◽  
M. Samarasinghe ◽  
N. Atapattu
Keyword(s):  
Precocious Puberty ◽  
Leydig Cell ◽  
Adult Height ◽  
Clinical Signs ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Rapid Progression ◽  
Delayed Presentation ◽  
The Past ◽  
Hormone Administration

Leydig cell tumors, most often benign, are a rare cause of isosexual gonadotropin-independent precocious puberty in boys due to secretion of testosterone. Very rarely do these tumors produce estrogen, causing gynecomastia. Testicular sparing surgery is the mainstay of treatment currently although radical orchidectomy was the choice in the past. Following surgery, clinical signs improve along with a revision of biochemical changes. Occasionally, it has been reported few children are progressed to gonadotropin-dependent precocious puberty (GDPP) after initial clinical and biochemical recovery. Gonadotropin receptor analogs have been successful on them to halt the progression of puberty, and growth hormone administration has been used to optimize the adult height. Here, we report a case of a 10-year-old boy who presented very late due to failure in recognition of features of puberty due to a Leydig cell tumor. Even though he underwent successful radical orchidectomy, just within 1 month following surgery, he entered GDPP in contrast to the published cases where it was earliest detected at 3 months.

scholarly journals Sertoli-Leydig Cell Tumor of the Ovary, a Rare Cause of Precocious Puberty in a 12-Month-Old Infant

2002 ◽  
Vol 87 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Catherine S. Choong ◽  
Peter J. Fuller ◽  
Simon Chu ◽  
Yvette Jeske ◽  
Francis Bowling ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Leydig Cell ◽  
Central Precocious Puberty ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Total Serum ◽  
Surgical Removal ◽  
Mrna Levels ◽  
Lh Receptor ◽  
Early Juvenile Stage

We report a 12-month-old infant who presented with a 4-month history of isosexual precocious puberty secondary to an estrogenizing Sertoli-Leydig cell tumor of the ovary. Total serum immunoreactive inhibin and subunits A and B were markedly elevated before surgical resection and subsequently decreased 7 wk later into the normal prepubertal range. Twenty weeks following surgical removal, the patient presented again with central precocious puberty; inhibin B levels were raised on this occasion, a luteinizing releasing hormone stimulation test confirmed central precocious puberty. This is the youngest reported occurrence of this rare sex cord stromal neoplasm. The prognosis of this extremely rare tumor presenting at this early juvenile stage is uncertain. This report illustrates the usefulness of serum inhibin as a tumor marker during therapeutic suppression with leuprorelin acetate for central precocious puberty. Analysis of genomic and tumor DNA revealed a normal nucleotide sequence for the LH receptor and the Gαs gene. To understand the molecular pathogenesis of this tumor we analyzed mRNA levels for the inhibin A and B subunits, FSH receptor, LH receptor aromatase, steroidogenic factor-1 and the ER β genes. Molecular characterization reveals the presence of genes specific for granulosa and Leydig cells; the relative expression of these genes, in addition to its histologic characteristics, suggests that this tumor may result from a dysdifferentiation of a primordial follicle.

scholarly journals True Precocious Puberty Following Treatment of a Leydig Cell Tumor: Two Case Reports and Literature Review

2015 ◽  
Vol 3 ◽  
Author(s):  
Alberto Verrotti ◽  
Laura Penta ◽  
Letizia Zenzeri ◽  
Laura Lucchetti ◽  
Paolo Giovenali ◽  
...  
Keyword(s):  
Literature Review ◽  
Precocious Puberty ◽  
Leydig Cell ◽  
Case Reports ◽  
Leydig Cell Tumor ◽  
Cell Tumor

scholarly journals Precocious Puberty Associated with Testicular Hormone-secreting Leydig Cell Tumor

Cureus ◽  
2019 ◽  
Author(s):  
Eid Alagha ◽  
Shahd E Kafi ◽  
Mohamed Abdelmaksoud Shazly ◽  
Abdulmoein Al-Agha
Keyword(s):  
Precocious Puberty ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor

scholarly journals ПАТОМОРФОЛОГІЧНІ ОСОБЛИВОСТІ ЛЕЙДИГОМИ СОБАК

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 217-220
Author(s):  
N.I. Shestiaieva ◽  
Y.V. Osadchuk
Keyword(s):  
Leydig Cell ◽  
Germ Cell Tumors ◽  
Clinical Signs ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Histological Structure ◽  
Testicular Tumors ◽  
Stromal Tumors ◽  
Eosinophilic Cytoplasm ◽  
Sex Cord Stromal Tumors

The research for the study of morphological, clinical and macroscopic characteristics of the different histological types of canine testicular tumors. Material was obtained during a routine surgery for the removal of testicular tumors in dogs in clinics of veterinary medicine in Kiev. Tumors were divided into sex-cord stromal tumors and germ cell tumors. Among the sex-cord stromal tumors recorded leydig (interstitial) and sertoli cell tumors. Macroscopical and histologic characteristics of canine interstitial (Leydig) cell tumor are described. It is 12.5% of all testicular tumors. The average age of dogs is 9 years. Largest share is breeds dog such as foxterriers and toyterriers. Interstitial (Leydig) cell tumor has a slower growth compared to other tumors the testicle, no metastases. Half the animals had no clinical signs. Mostinterstitial (Leydig) cell tumor go together with the pathology of adnexal structures. This is because Leydig cell tumor lead to increased levels of androgens. This fact may cause pathology of adnexal structures. Neoplasms are recorded both on the right and the left testis. Leydig cell tumor was not related to the cryptorchid testicles. Most tumors regular oval, brown or gray color, different texture and size with no signs of necrosis or ulceration. The average volume of tumors ranged from 2 to 20 cm2. Microscopically, the tumor is composed of cells that resemble Leydig cells and that are arranged into islands or tubular structures. Find polygonal eosinophilic cells with granular or vacuolated, which contains lipids. Nuclei were round mesh of chromatin and distinct nucleolus. Sometimes noted the large cells with 1, 2 or more nucleoli. In some cases, found elongated fusiform cells with small nuclei and granular eosinophilic cytoplasm. Tumor stroma characterized by calcification. Note mitotically active cells. Cysts lined by tumor cells are present in some tumors. Distinction between benign and malignant forms on purely histological criteria, in the absence of metastasis, often is difficult. Studies on the features of histological structure of testicular tumors will optimize the histological diagnosis of neoplasms.

Precocious Puberty in a Child with Unilateral Leydig Cell Tumor of the Testis following Orchiopexy

1993 ◽  
Vol 150 (5 Part 1) ◽  
pp. 1483-1485 ◽  
Author(s):  
Andrew J. Kirsch ◽  
William Bastian ◽  
Harris L. Cohen ◽  
Kenneth I. Glassberg
Keyword(s):  
Precocious Puberty ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor
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