scholarly journals Long Term Complete Remission of Intraluminal Squamous Cell Carcinoma by Bronchoscopic Electrosurgery

1997 ◽  
Vol 4 (1) ◽  
pp. 9-11
Author(s):  
Peter M. J. M. De Vries ◽  
Pieter E. Postmus ◽  
Tom G. Sutedja
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Complete Remission ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Sleeve Lobectomy ◽  
Intraluminal Tumor ◽  
The Moment ◽  
The Right

A patient is described with a synchronous intraluminal squamous cell carcinoma of the left upper lobe carina. He refused photodynamic therapy after sleeve lobectomy of the right upper lobe. The intraluminal tumor was treated with fiberoptic bronchoscopic electrosurgery. Complete remission was achieved, at the moment already for 36 months.

Results of Long-term Follow-up of Photodynamic Therapy for Roentgenographically Occult Bronchogenic Squamous Cell Carcinoma

CHEST Journal ◽  
2009 ◽  
Vol 136 (2) ◽  
pp. 369-375 ◽  
Author(s):  
Chiaki Endo ◽  
Akira Miyamoto ◽  
Akira Sakurada ◽  
Hirokazu Aikawa ◽  
Motoyasu Sagawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Long Term Follow Up

PDT for Tis-T2N0 Oral Cavity and Oropharyngeal Malignancies

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P34-P34
Author(s):  
Vanessa G Schweitzer ◽  
Melissa L Somers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Complete Remission ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Field Cancerization ◽  
Multiple Drug ◽  
Disease Free

Objective To evaluate the efficacy of PHOTOFRIN-mediated photodynamic therapy (PDT) for treatment of diffuse ‘field cancerization’ and Tis-T2N0M0 squamous cell carcinoma (SqCCa) of the oral cavity and oral pharynx in patients not amenable to or that failed conventional head and neck treatment. Methods This is nonrandomized prospective study of 28 patients with field cancerization and early stage Tis-T2N0M0 squamous cell carcinoma of the oral cavity/oropharynx treated with PHOTOFRIN-mediated PDT. Intravenous PHOTOFRIN (porfimer sodium)(dose 2.0 mg/kg) was administered outpatient, followed 48–60 hours later by intraoperative photoactivation at 630nm via fiberoptic microlens surface delivery (surgical light dose 50–100 J/cm2). Results 21 of 27 patients (77%) have demonstrated complete remission (follow-up 1 month to 12 years). There were 5 patients that had partial remission with recurrence observed at 3, 3, 8, 22, and 23 months subsequently retreated with conventional therapy. All locally disease-free individuals were followed up between 1 to 144 months. 14 of the 21 patients in complete remission were disease-free for a period greater than 1 year following photodynamic therapy. Conclusions PHOTOFRIN-mediated photodynamic therapy can be used as a primary modality to treat Tis-T2N0 tumors of the oral cavity and oropharynx or for treatment for those that have failed prior surgery and/or radiation therapy. PDT allows for preservation of function and structure with absence of systemic toxicity, and patients may have multiple drug administrations and laser light retreatments for local disease control.

scholarly journals 066 Role of TGF-β1 in the resistance of squamous cell carcinoma to photodynamic therapy

2021 ◽  
Vol 141 (5) ◽  
pp. S12
Author(s):  
M. Gallego Rentero ◽  
M. Gutiérrez-Pérez ◽  
M. Portillo-Esnaola ◽  
M. Mataix ◽  
L. Najera ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tgf Β1
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