scholarly journals Different Responses of Proliferating and Resting Tumor HeLa Cells to Pulsed High Repetition Rate Low-Intensity Laser Light at 271 nm

1983 ◽  
Vol 1 (3) ◽  
pp. 153-161 ◽  
Author(s):  
T. I. Karu ◽  
G. S. Kalendo ◽  
V. S. Letokhov ◽  
V. V. Lobko

The action of pulsed high repetition rate UV laser radiation (2-nd harmonic of Cu vapor laser, λ = 271 nm, pulse duration 18 nsec, repetition rate 10 kHz) on proliferating and resting HeLa cells has been studied. The intensity of DNA synthesis changes after such kinds of irradiation for both types of cells. For proliferating cells DNA synthesis is suppressed, while for the resting ones stimulation is observed in the dose range from 0.05 to 5 J/m2.

Author(s):  
K. M. George ◽  
J. T. Morrison ◽  
S. Feister ◽  
G. K. Ngirmang ◽  
J. R. Smith ◽  
...  

High-intensity laser–plasma interactions produce a wide array of energetic particles and beams with promising applications. Unfortunately, the high repetition rate and high average power requirements for many applications are not satisfied by the lasers, optics, targets, and diagnostics currently employed. Here, we aim to address the need for high-repetition-rate targets and optics through the use of liquids. A novel nozzle assembly is used to generate high-velocity, laminar-flowing liquid microjets which are compatible with a low-vacuum environment, generate little to no debris, and exhibit precise positional and dimensional tolerances. Jets, droplets, submicron-thick sheets, and other exotic configurations are characterized with pump–probe shadowgraphy to evaluate their use as targets. To demonstrate a high-repetition-rate, consumable, liquid optical element, we present a plasma mirror created by a submicron-thick liquid sheet. This plasma mirror provides etalon-like anti-reflection properties in the low field of 0.1% and high reflectivity as a plasma, 69%, at a repetition rate of 1 kHz. Practical considerations of fluid compatibility, in-vacuum operation, and estimates of maximum repetition rate are addressed. The targets and optics presented here demonstrate a potential technique for enabling the operation of laser–plasma interactions at high repetition rates.


1981 ◽  
Vol 11 (6) ◽  
pp. 806-808 ◽  
Author(s):  
A N Zherikin ◽  
V S Letokhov ◽  
V I Mishin ◽  
V P Belyaev ◽  
A N Evtyunin ◽  
...  

2012 ◽  
Vol 37 (2) ◽  
pp. 190 ◽  
Author(s):  
Martin Straub ◽  
Maziar Afshar ◽  
Dara Feili ◽  
Helmut Seidel ◽  
Karsten König

2001 ◽  
Vol 79 (4) ◽  
pp. 452-454 ◽  
Author(s):  
A. Costela ◽  
I. Garcı́a-Moreno ◽  
R. Sastre ◽  
D. W. Coutts ◽  
C. E. Webb

2021 ◽  
Vol 11 (4) ◽  
pp. 1680
Author(s):  
Timofej Chagovets ◽  
Stanislav Stanček ◽  
Lorenzo Giuffrida ◽  
Andriy Velyhan ◽  
Maksym Tryus ◽  
...  

Fast solid target delivery and plasma-ion detection systems have been designed and developed to be used in high intensity laser-matter interaction experiments. We report on recent progress in the development and testing of automated systems to refresh solid targets at a high repetition rate during high peak power laser operation (>1 Hz), along with ion diagnostics and corresponding data collection and real-time analysis methods implemented for future use in a plasma-based ion acceleration beamline for multidisciplinary user applications.


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