Abstract P4-03-03: Determination of lymph node status using the primary tumor’s gene expression signature

2013 ◽  
Author(s):  
B Gyorffy ◽  
Z Sztupinszki ◽  
B Weltz ◽  
S-C Chen ◽  
S Quay
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Gene Expression Signature ◽  
Lymph Node Status ◽  
Expression Signature ◽  
Node Status

O53. Multicenter validation of a lymph node metastasis gene expression signature for head and neck squamous cell carcinomas

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S46
Author(s):  
F.K.J. Leusink ◽  
P.J. Slootweg ◽  
M.W.M. van den Brekel ◽  
R.J. Baatenburg de Jong ◽  
F.C.P. Holstege ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gene Expression Signature ◽  
Squamous Cell Carcinomas ◽  
Expression Signature ◽  
Node Metastasis ◽  
Multicenter Validation

PD.128 Gene expression profiles of oralsquamous cell carcinoma depending on lymph node status

2005 ◽  
Vol 1 (1) ◽  
pp. 104
Author(s):  
T. Fillies ◽  
H. Bürger ◽  
B. Brandt ◽  
D. Kemmmg ◽  
R. Werkmeister ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Lymph Node Status ◽  
Node Status

scholarly journals Differential Gene Expression in Primary Breast Tumors Associated with Lymph Node Metastasis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Rachel E. Ellsworth ◽  
Lori A. Field ◽  
Brad Love ◽  
Jennifer L. Kane ◽  
Jeffrey A. Hooke ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lymph Node ◽  
Breast Tumors ◽  
Host Susceptibility ◽  
Prognostic Indicators ◽  
Lymph Node Status ◽  
Primary Tumors ◽  
Node Negative ◽  
Node Positive ◽  
Node Status

Lymph node status remains one of the most useful prognostic indicators in breast cancer; however, current methods to assess nodal status disrupt the lymphatic system and may lead to secondary complications. Identification of molecular signatures discriminating lymph node-positive from lymph node-negative primary tumors would allow for stratification of patients requiring surgical assesment of lymph nodes. Primary breast tumors from women with negative () and positive () lymph node status matched for possible confounding factors were subjected to laser microdissection and gene expression data generated. Although ANOVA analysis (, fold-change >1.5) revealed 13 differentially expressed genes, hierarchical clustering classified 90% of node-negative but only 66% of node-positive tumors correctly. The inability to derive molecular profiles of metastasis in primary tumors may reflect tumor heterogeneity, paucity of cells within the primary tumor with metastatic potential, influence of the microenvironment, or inherited host susceptibility to metastasis.

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