scholarly journals Serum Vitamin D and Breast Density in Breast Cancer Survivors

2010 ◽  
Vol 19 (2) ◽  
pp. 412-417 ◽  
Author(s):  
Marian L. Neuhouser ◽  
Leslie Bernstein ◽  
Bruce W. Hollis ◽  
Liren Xiao ◽  
Anita Ambs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Breast Density ◽  
Breast Cancer Survivors ◽  
Serum Vitamin ◽  
Serum Vitamin D

scholarly journals Assessing vitamin D and mammographic breast density in Alaskan women

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Narjust Duma ◽  
Ivana Croghan ◽  
Sarah Jenkins ◽  
Celine Vachon ◽  
Loni Neal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Breast Density ◽  
Pearson Correlation ◽  
Serum Vitamin ◽  
Mammographic Breast Density ◽  
Serum Vitamin D ◽  
Populations At Risk ◽  
Vitamin D Levels

Vitamin D deficiency and high breast density may be associated with increased breast cancer risk. We examined a possible association between vitamin D levels and mammographic breast density in a population of Alaskan women. Patients seen in the Mayo Clinic-Alaska Native Medical Center telemedicine program from December 2014 to December 2017 were enrolled in the study. Pearson correlation was used to estimate the association between mammographic breast density and vitamin D levels. Of the 33 women enrolled, 70% of women self-identified as American Indian/Alaskan Native, 12% as White, 6% as Native Hawaiian/Pacific Islander and 12% as other. Nineteen (58%) participants were taking vitamin D supplementation. No correlation was identified between breast density and serum vitamin D levels overall (correlation= –0.03). Larger studies controlling for vitamin supplementation are needed, as this association could potentially impact breast cancer rates in populations at risk for vitamin D deficiency.

Vitamin D Receptor (VDR) Allelic Variants Correlating with Response to Vitamin D3 Supplementation in Breast Cancer Survivors

2021 ◽  
pp. 1-14
Author(s):  
Elham Kazemian ◽  
Sayed Hossein Davoodi ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Breast Cancer Survivors ◽  
Allelic Variants ◽  
Vitamin D3 Supplementation

scholarly journals Vitamin D Deficiency in Postmenopausal Breast Cancer Survivors

2012 ◽  
Vol 21 (4) ◽  
pp. 456-462 ◽  
Author(s):  
Claire F. Friedman ◽  
Angela DeMichele ◽  
H. Irene Su ◽  
Rui Feng ◽  
Shiv Kapoor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Deficiency ◽  
Breast Cancer Survivors ◽  
Postmenopausal Breast Cancer

scholarly journals Does the evidence for an inverse relationship between serum vitamin D status and breast cancer risk satisfy the Hill criteria?

2012 ◽  
Vol 4 (2) ◽  
pp. 152-157 ◽  
Author(s):  
Sharif B. Mohr ◽  
Edward D. Gorham ◽  
John E. Alcaraz ◽  
Christopher I. Kane ◽  
Caroline A. Macera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Inverse Relationship ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Hill Criteria ◽  
The Hill

Breast cancer survivors and vitamin D: A review

Nutrition ◽  
2010 ◽  
Vol 26 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Stephanie L. Hines ◽  
H. Keels S. Jorn ◽  
Kristine M. Thompson ◽  
Jan M. Larson
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Breast Cancer Survivors

scholarly journals Vitamin D Receptor Genetic Variation and Cancer Biomarkers among Breast Cancer Patients Supplemented with Vitamin D3: A Single-Arm Non-Randomized Before and After Trial

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1264 ◽  
Author(s):  
Elham Kazemian ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
Alison M. Mondul ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Adhesion Molecule ◽  
Vitamin D3 ◽  
Breast Cancer Survivors ◽  
Cancer Biomarkers ◽  
Vitamin D3 Supplementation ◽  
Vdr Polymorphisms

We investigated whether vitamin D receptor (VDR) polymorphisms were associated with cancer biomarkers, i.e., E-cadherin, matrix metallopeptidase 9 (MMP9), interferon β (IFNβ), soluble intercellular adhesion molecule-1 (s-ICAM-1), soluble vascular cell adhesion molecule-1 (s-VCAM-1), tumor necrosis factorα (TNFα), interleukin 6 (IL6), plasminogen activator inhibitor-1(PAI-1), and human high sensitivity C-reactive protein (hs-CRP), among breast cancer survivors who received vitamin D3 supplementation. In a single-arm non-randomized pre- and post trial, 176 breast cancer survivors who had completed treatment protocol including surgery, radio and chemotherapy were enrolled in the study and received 4000 IU of vitamin D3 daily for 12 weeks. The association between the VDR SNPs (ApaI, TaqI, FokI, BsmI and Cdx2) and response variable changes was assessed using linear regression, utilizing the “association” function in the R package “SNPassoc”. We observed that women with AA and GA [codominant model (AA compared to GG) and (GA compared to GG); dominant model (AA & GA compared to GG)] genotypes of Cdx2 showed higher increase in plasma MMP9 levels compared to the GG category. In addition, carriers of BsmI bb showed greater decrease in circulating TNFα levels after vitamin D3 supplementation [recessive model (bb compared to BB & Bb]. Likewise, significant associations were identified between haplotypes of VDR polymorphisms and on-study plasma MMP9 changes. However, our results indicate that VDR genetic polymorphisms were not associated with longitudinal changes in the remaining cancer biomarkers. Overall, our findings suggest that changes in certain inflammatory biomarkers in breast cancer survivors with low plasma 25(OH)D levels, supplemented with vitamin D3, may depend on VDR SNPs and haplotypes.

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